Transcriptomic Evidence Reveals the Molecular Basis for Functional Differentiation of Hemocytes in a Marine Invertebrate, Crassostrea gigas

• Published in: Frontiers in immunology Vol. 11; p. 911
• Main Authors: Mao, Fan, Wong, Nai-Kei, Lin, Yue, Zhang, Xiangyu, Liu, Kunna, Huang, Minwei, Xu, Duo, Xiang, Zhiming, Li, Jun, Zhang, Yang, Yu, Ziniu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.05.2020
• Subjects: Animals; Cdc42; cdc42 GTP-Binding Protein - genetics; cdc42 GTP-Binding Protein - metabolism; Crassostrea - genetics; Crassostrea - immunology; Crassostrea - metabolism; Evolution, Molecular; Fos; functional differentiation; Gene Expression Profiling; Gene Regulatory Networks; granulocytes; Granulocytes - immunology; Granulocytes - metabolism; Hemocytes - immunology; Hemocytes - metabolism; Immunology; Immunophenotyping; oyster; Phenotype; Protein Interaction Maps; Proto-Oncogene Proteins c-fos - genetics; Proto-Oncogene Proteins c-fos - metabolism; Transcriptome; granulocytes; oyster; Fos; functional differentiation; Cdc42

Hemocytes play unequivocally central roles in host immune defense of bivalve mollusks, though the exact mechanisms underlying their functional differentiation are only partially understood. To this end, granulocytes and hyalinocytes were sorted via flow cytometry from hemocytes of the Pacific oyster...