Oral Immunization of Chickens With Recombinant Lactobacillus plantarum Vaccine Against Early ALV-J Infection
In this study, a novel oral vaccine of recombinant ( ) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup J Avian Leukosis Virus (ALV-J) infection were assessed. In the current study, the gp85 protein of ALV-J was expressed on the surface of with...
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| Published in | Frontiers in immunology Vol. 10; p. 2299 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Media S.A
02.10.2019
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| Abstract | In this study, a novel oral vaccine of recombinant
(
) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup J Avian Leukosis Virus (ALV-J) infection were assessed. In the current study, the gp85 protein of ALV-J was expressed on the surface of
with the surface-display motif,
, by constructing a shuttle vector
. Surface localization of the fusion protein was verified by western blotting and flow cytometry. Subsequently, Specific Pathogen Free Hy-Line Brown layer chickens were orally vaccinated with the recombinant
and presented with high levels of serum immunoglobulin G (IgG) and secretory immunoglobulin A (sIgA) titers in bile and duodenal-mucosal fluid. After challenged with ALV-J of a 3 × 10
50% tissue culture infective dose (TCID50), serum samples of the chickens were collected and viremia was analyzed. Results showed that, compared to the
and PBS control group, the recombinant
group showed a significant rise in antibody levels after inoculation, and provide improved protection against ALV-J according to viremia detection. These results indicate that oral immunization with the recombinant
provided an effective means for eliciting protective immune response against early ALV-J infection. |
|---|---|
| AbstractList | In this study, a novel oral vaccine of recombinant
(
) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup J Avian Leukosis Virus (ALV-J) infection were assessed. In the current study, the gp85 protein of ALV-J was expressed on the surface of
with the surface-display motif,
, by constructing a shuttle vector
. Surface localization of the fusion protein was verified by western blotting and flow cytometry. Subsequently, Specific Pathogen Free Hy-Line Brown layer chickens were orally vaccinated with the recombinant
and presented with high levels of serum immunoglobulin G (IgG) and secretory immunoglobulin A (sIgA) titers in bile and duodenal-mucosal fluid. After challenged with ALV-J of a 3 × 10
50% tissue culture infective dose (TCID50), serum samples of the chickens were collected and viremia was analyzed. Results showed that, compared to the
and PBS control group, the recombinant
group showed a significant rise in antibody levels after inoculation, and provide improved protection against ALV-J according to viremia detection. These results indicate that oral immunization with the recombinant
provided an effective means for eliciting protective immune response against early ALV-J infection. In this study, a novel oral vaccine of recombinant Lactobacillus plantarum (L. plantarum) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup J Avian Leukosis Virus (ALV-J) infection were assessed. In the current study, the gp85 protein of ALV-J was expressed on the surface of L. plantarum with the surface-display motif, pgsA, by constructing a shuttle vector pMG36e:pgsA:gp85. Surface localization of the fusion protein was verified by western blotting and flow cytometry. Subsequently, Specific Pathogen Free Hy-Line Brown layer chickens were orally vaccinated with the recombinant L. plantarum and presented with high levels of serum immunoglobulin G (IgG) and secretory immunoglobulin A (sIgA) titers in bile and duodenal-mucosal fluid. After challenged with ALV-J of a 3 × 103 50% tissue culture infective dose (TCID50), serum samples of the chickens were collected and viremia was analyzed. Results showed that, compared to the L. plantarum and PBS control group, the recombinant L. plantarum group showed a significant rise in antibody levels after inoculation, and provide improved protection against ALV-J according to viremia detection. These results indicate that oral immunization with the recombinant L. plantarum provided an effective means for eliciting protective immune response against early ALV-J infection.In this study, a novel oral vaccine of recombinant Lactobacillus plantarum (L. plantarum) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup J Avian Leukosis Virus (ALV-J) infection were assessed. In the current study, the gp85 protein of ALV-J was expressed on the surface of L. plantarum with the surface-display motif, pgsA, by constructing a shuttle vector pMG36e:pgsA:gp85. Surface localization of the fusion protein was verified by western blotting and flow cytometry. Subsequently, Specific Pathogen Free Hy-Line Brown layer chickens were orally vaccinated with the recombinant L. plantarum and presented with high levels of serum immunoglobulin G (IgG) and secretory immunoglobulin A (sIgA) titers in bile and duodenal-mucosal fluid. After challenged with ALV-J of a 3 × 103 50% tissue culture infective dose (TCID50), serum samples of the chickens were collected and viremia was analyzed. Results showed that, compared to the L. plantarum and PBS control group, the recombinant L. plantarum group showed a significant rise in antibody levels after inoculation, and provide improved protection against ALV-J according to viremia detection. These results indicate that oral immunization with the recombinant L. plantarum provided an effective means for eliciting protective immune response against early ALV-J infection. In this study, a novel oral vaccine of recombinant Lactobacillus plantarum (L. plantarum) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup J Avian Leukosis Virus (ALV-J) infection were assessed. In the current study, the gp85 protein of ALV-J was expressed on the surface of L. plantarum with the surface-display motif, pgsA, by constructing a shuttle vector pMG36e:pgsA:gp85. Surface localization of the fusion protein was verified by western blotting and flow cytometry. Subsequently, Specific Pathogen Free Hy-Line Brown layer chickens were orally vaccinated with the recombinant L. plantarum and presented with high levels of serum immunoglobulin G (IgG) and secretory immunoglobulin A (sIgA) titers in bile and duodenal-mucosal fluid. After challenged with ALV-J of a 3 × 103 50% tissue culture infective dose (TCID50), serum samples of the chickens were collected and viremia was analyzed. Results showed that, compared to the L. plantarum and PBS control group, the recombinant L. plantarum group showed a significant rise in antibody levels after inoculation, and provide improved protection against ALV-J according to viremia detection. These results indicate that oral immunization with the recombinant L. plantarum provided an effective means for eliciting protective immune response against early ALV-J infection. In this study, a novel oral vaccine of recombinant Lactobacillus plantarum ( L. plantarum ) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup J Avian Leukosis Virus (ALV-J) infection were assessed. In the current study, the gp85 protein of ALV-J was expressed on the surface of L. plantarum with the surface-display motif, pgsA , by constructing a shuttle vector pMG36e:pgsA:gp85 . Surface localization of the fusion protein was verified by western blotting and flow cytometry. Subsequently, Specific Pathogen Free Hy-Line Brown layer chickens were orally vaccinated with the recombinant L. plantarum and presented with high levels of serum immunoglobulin G (IgG) and secretory immunoglobulin A (sIgA) titers in bile and duodenal-mucosal fluid. After challenged with ALV-J of a 3 × 10 3 50% tissue culture infective dose (TCID50), serum samples of the chickens were collected and viremia was analyzed. Results showed that, compared to the L. plantarum and PBS control group, the recombinant L. plantarum group showed a significant rise in antibody levels after inoculation, and provide improved protection against ALV-J according to viremia detection. These results indicate that oral immunization with the recombinant L. plantarum provided an effective means for eliciting protective immune response against early ALV-J infection. |
| Author | Liu, Kangping Liu, Yongxia Geng, Na Shi, Mengke Qu, Yi Liu, Jianzhu Xu, Yuliang Wang, Shenghua Zhou, Dong |
| AuthorAffiliation | 5 Nanjing Entry-Exit Inspection and Quarantine Bureau , Nanjing , China 3 Research Center for Animal Disease Control Engineering, Shandong Agricultural University , Tai'an , China 2 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University , Tai'an , China 1 College of Veterinary Medicine, Shandong Agricultural University , Tai'an , China 4 College of Veterinary Medicine, Northwest Agriculture and Forestry University , Yangling , China |
| AuthorAffiliation_xml | – name: 1 College of Veterinary Medicine, Shandong Agricultural University , Tai'an , China – name: 4 College of Veterinary Medicine, Northwest Agriculture and Forestry University , Yangling , China – name: 2 Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University , Tai'an , China – name: 5 Nanjing Entry-Exit Inspection and Quarantine Bureau , Nanjing , China – name: 3 Research Center for Animal Disease Control Engineering, Shandong Agricultural University , Tai'an , China |
| Author_xml | – sequence: 1 givenname: Shenghua surname: Wang fullname: Wang, Shenghua – sequence: 2 givenname: Na surname: Geng fullname: Geng, Na – sequence: 3 givenname: Dong surname: Zhou fullname: Zhou, Dong – sequence: 4 givenname: Yi surname: Qu fullname: Qu, Yi – sequence: 5 givenname: Mengke surname: Shi fullname: Shi, Mengke – sequence: 6 givenname: Yuliang surname: Xu fullname: Xu, Yuliang – sequence: 7 givenname: Kangping surname: Liu fullname: Liu, Kangping – sequence: 8 givenname: Yongxia surname: Liu fullname: Liu, Yongxia – sequence: 9 givenname: Jianzhu surname: Liu fullname: Liu, Jianzhu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31632395$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2019 Wang, Geng, Zhou, Qu, Shi, Xu, Liu, Liu and Liu. Copyright © 2019 Wang, Geng, Zhou, Qu, Shi, Xu, Liu, Liu and Liu. 2019 Wang, Geng, Zhou, Qu, Shi, Xu, Liu, Liu and Liu |
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| Keywords | pgsA oral immunization Lactobacillus plantarum gp85 protein ALV-J |
| Language | English |
| License | Copyright © 2019 Wang, Geng, Zhou, Qu, Shi, Xu, Liu, Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work Reviewed by: Hongwei Wang, Henan University of Science and Technology, China; Xiquan Zhang, South China Agricultural University, China This article was submitted to Comparative Immunology, a section of the journal Frontiers in Immunology Edited by: Laurel J. Gershwin, University of California, Davis, United States |
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) containing the gp85 protein was explored, and the effects of this vaccine on the prevention of subgroup... In this study, a novel oral vaccine of recombinant Lactobacillus plantarum (L. plantarum) containing the gp85 protein was explored, and the effects of this... In this study, a novel oral vaccine of recombinant Lactobacillus plantarum ( L. plantarum ) containing the gp85 protein was explored, and the effects of this... |
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| Title | Oral Immunization of Chickens With Recombinant Lactobacillus plantarum Vaccine Against Early ALV-J Infection |
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