Multi-omics Analysis of Prognostic Significance and Immune Infiltration of FASTK Family Members in Kidney Renal Clear Cell Carcinoma
Objective: The Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression post-transcriptionally. Nonetheless, there is a paucity of study about the role of the FASTK family in kidney renal clear cell carcinoma (KIRC)...
Saved in:
| Published in | Evolutionary bioinformatics online Vol. 19; p. 11769343231212078 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London, England
SAGE Publications
01.01.2023
Sage Publications Ltd SAGE Publishing |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Objective:
The Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression post-transcriptionally. Nonetheless, there is a paucity of study about the role of the FASTK family in kidney renal clear cell carcinoma (KIRC). This study was conducted to explore the correlation of FASTK family genes with expression, prognosis, and immune infiltration in KIRC.
Methods:
We collected the data from the UALCAN, GeneMANIA, STRING, CancerSEA, cBioPortal, Kaplan-Meier plotter, GEPIA, TISIDB and TIMER databases to evaluate the genetic alterations, differential expression, prognostic significance, and immune cell infiltration of FASTKs in patients with KIRC.
Results:
In tumor tissues of KIRC, the mRNA expression level of FASTK and TBRG4 was elevated, whereas that of FASTKD1, FASTKD2, and FASTKD5 was lowered compared with normal tissues (P < .05). Patients with KIRC and high FASTK and Transforming growth factor β regulator 4 (TBRG4) expression had worse overall survival (OS) and disease specific survival (DFS), while those with lower expression of FASTKD2/3/5 had worse outcomes. FASTK was positively correlated with DNA damage. FASTKD1 was positively related to differentiation. FASTKD2 was inversely related to proliferation and FASTKD5 was inversely related to invasion and EMT in KIRC cells. FASTK expression in KIRC was inversely linked to the presence of several immune cells including Tgd, macrophages, Tcm, and Mast cells (P < .05).
Conclusions:
Our research provided fresh insight and in-depth analysis to the selection of prognostic biological markers of FASTK family members in KIRC. |
|---|---|
| AbstractList | ObjectiveThe Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression post-transcriptionally. Nonetheless, there is a paucity of study about the role of the FASTK family in kidney renal clear cell carcinoma (KIRC). This study was conducted to explore the correlation of FASTK family genes with expression, prognosis, and immune infiltration in KIRC.MethodsWe collected the data from the UALCAN, GeneMANIA, STRING, CancerSEA, cBioPortal, Kaplan-Meier plotter, GEPIA, TISIDB and TIMER databases to evaluate the genetic alterations, differential expression, prognostic significance, and immune cell infiltration of FASTKs in patients with KIRC.ResultsIn tumor tissues of KIRC, the mRNA expression level of FASTK and TBRG4 was elevated, whereas that of FASTKD1, FASTKD2, and FASTKD5 was lowered compared with normal tissues (P < .05). Patients with KIRC and high FASTK and Transforming growth factor β regulator 4 (TBRG4) expression had worse overall survival (OS) and disease specific survival (DFS), while those with lower expression of FASTKD2/3/5 had worse outcomes. FASTK was positively correlated with DNA damage. FASTKD1 was positively related to differentiation. FASTKD2 was inversely related to proliferation and FASTKD5 was inversely related to invasion and EMT in KIRC cells. FASTK expression in KIRC was inversely linked to the presence of several immune cells including Tgd, macrophages, Tcm, and Mast cells (P < .05).ConclusionsOur research provided fresh insight and in-depth analysis to the selection of prognostic biological markers of FASTK family members in KIRC. Objective: The Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression post-transcriptionally. Nonetheless, there is a paucity of study about the role of the FASTK family in kidney renal clear cell carcinoma (KIRC). This study was conducted to explore the correlation of FASTK family genes with expression, prognosis, and immune infiltration in KIRC. Methods: We collected the data from the UALCAN, GeneMANIA, STRING, CancerSEA, cBioPortal, Kaplan-Meier plotter, GEPIA, TISIDB and TIMER databases to evaluate the genetic alterations, differential expression, prognostic significance, and immune cell infiltration of FASTKs in patients with KIRC. Results: In tumor tissues of KIRC, the mRNA expression level of FASTK and TBRG4 was elevated, whereas that of FASTKD1, FASTKD2, and FASTKD5 was lowered compared with normal tissues (P < .05). Patients with KIRC and high FASTK and Transforming growth factor β regulator 4 (TBRG4) expression had worse overall survival (OS) and disease specific survival (DFS), while those with lower expression of FASTKD2/3/5 had worse outcomes. FASTK was positively correlated with DNA damage. FASTKD1 was positively related to differentiation. FASTKD2 was inversely related to proliferation and FASTKD5 was inversely related to invasion and EMT in KIRC cells. FASTK expression in KIRC was inversely linked to the presence of several immune cells including Tgd, macrophages, Tcm, and Mast cells (P < .05). Conclusions: Our research provided fresh insight and in-depth analysis to the selection of prognostic biological markers of FASTK family members in KIRC. Objective: The Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression post-transcriptionally. Nonetheless, there is a paucity of study about the role of the FASTK family in kidney renal clear cell carcinoma (KIRC). This study was conducted to explore the correlation of FASTK family genes with expression, prognosis, and immune infiltration in KIRC. Methods: We collected the data from the UALCAN, GeneMANIA, STRING, CancerSEA, cBioPortal, Kaplan-Meier plotter, GEPIA, TISIDB and TIMER databases to evaluate the genetic alterations, differential expression, prognostic significance, and immune cell infiltration of FASTKs in patients with KIRC. Results: In tumor tissues of KIRC, the mRNA expression level of FASTK and TBRG4 was elevated, whereas that of FASTKD1, FASTKD2, and FASTKD5 was lowered compared with normal tissues (P < .05). Patients with KIRC and high FASTK and Transforming growth factor β regulator 4 (TBRG4) expression had worse overall survival (OS) and disease specific survival (DFS), while those with lower expression of FASTKD2/3/5 had worse outcomes. FASTK was positively correlated with DNA damage. FASTKD1 was positively related to differentiation. FASTKD2 was inversely related to proliferation and FASTKD5 was inversely related to invasion and EMT in KIRC cells. FASTK expression in KIRC was inversely linked to the presence of several immune cells including Tgd, macrophages, Tcm, and Mast cells (P < .05). Conclusions: Our research provided fresh insight and in-depth analysis to the selection of prognostic biological markers of FASTK family members in KIRC. |
| Author | Xiang, Qi Liu, Yufeng Zhong, Guanghui Chen, Haiping Wu, Dali Wang, Tao Yan, Lingfei |
| Author_xml | – sequence: 1 givenname: Guanghui surname: Zhong fullname: Zhong, Guanghui organization: Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China – sequence: 2 givenname: Dali surname: Wu fullname: Wu, Dali organization: Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China – sequence: 3 givenname: Haiping surname: Chen fullname: Chen, Haiping organization: Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China – sequence: 4 givenname: Lingfei surname: Yan fullname: Yan, Lingfei organization: Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China – sequence: 5 givenname: Qi surname: Xiang fullname: Xiang, Qi organization: Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China – sequence: 6 givenname: Yufeng surname: Liu fullname: Liu, Yufeng organization: Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China – sequence: 7 givenname: Tao orcidid: 0000-0001-8690-6097 surname: Wang fullname: Wang, Tao organization: Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China |
| BookMark | eNp1kk9v1DAQxSNUJNrCB-BmiQuXLf6TxPYJrVYsrNoKRMvZcuxx8Cqxi51U2jsfHIetgIK42NabNz95nuasOgkxQFW9JPiCEM7flKOVrGaUEUoo5uJJdbpoq0U8-eP9rDrLeY9x3RTltPp-PQ-TX8XRm4zWQQ-H7DOKDn1KsQ8xT96gG98H77zRwQDSwaLdOM4B0C44P0xJTz6GpWW7vrm9RFs9-uGArmHsIGXkA7r0NsABfYaCR5sBdEIbGMpTJ-NDHPXz6qnTQ4YXD_d59WX77nbzYXX18f1us75ambql00p2QsvGtLxrHBWNBNdK4hyxmBtsS9EyB0J0bV2bjhnKa2KFKdaacS4oYefV7si1Ue_VXfKjTgcVtVc_hZh6pVOZeADVcNpgyZghJaoatx0YyWxLQXInrGwK6-2RdTd3I1gDoSQxPII-rgT_VfXxXhHcClbjuhBePxBS_DZDntTosynB6ABxzooK2QpMWiqK9dVf1n2cU4mzuCTFROKGLeORo8ukmHMC9-s3BKtlS9Q_W1J6Lo49Wffwm_r_hh9GNb32 |
| Cites_doi | 10.1016/S0140-6736(17)31827-5 10.1007/978-1-4939-3578-9_6 10.1159/000178873 10.1016/j.genrep.2017.07.001 10.1182/blood-2008-04-153031 10.1093/nar/gkz430 10.1016/j.neo.2017.05.002 10.1200/JCO.2005.03.6830 10.1016/j.bbrc.2010.09.075 10.1158/1541-7786.MCR-16-0115 10.1002/jcb.29468 10.1093/nar/gky1131 10.1097/MOU.0000000000000788 10.3322/caac.21387 10.2147/OTT.S56370 10.1056/NEJMoa1510665 10.1002/ijc.25901 10.1093/nar/gky939 10.1093/bioinformatics/btz210 10.1158/0008-5472.CAN-11-1620 10.1002/path.2440 10.1016/j.immuni.2013.10.003 10.1016/j.semcancer.2018.07.001 10.1002/cncr.23776 10.18632/oncotarget.4113 10.1016/j.semcancer.2018.05.004 10.1016/j.celrep.2018.06.032 10.1038/ni.3799 10.1126/scisignal.2004088 10.1093/nar/gkq537 10.1016/j.eururo.2018.08.036 10.1186/s40425-016-0180-7 10.1111/j.1464-410X.2010.09555.x 10.1126/science.8493574 10.3389/fgene.2020.00992 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023 The Author(s) 2023. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2023 2023 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses |
| Copyright_xml | – notice: The Author(s) 2023 – notice: The Author(s) 2023. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2023 2023 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses |
| DBID | AFRWT AAYXX CITATION 7QO 7SC 7SN 8FD 8FE 8FG 8FH ABUWG AFKRA ARAPS AYAGU AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 GNUQQ HCIFZ JQ2 K7- L7M LK8 L~C L~D M7P P5Z P62 P64 PIMPY PQEST PQQKQ PQUKI PRINS RC3 7X8 5PM DOA |
| DOI | 10.1177/11769343231212078 |
| DatabaseName | Sage Journals GOLD Open Access 2024 CrossRef Biotechnology Research Abstracts Computer and Information Systems Abstracts Ecology Abstracts Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection Australia & New Zealand Database ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database ProQuest Central Student SciTech Premium Collection ProQuest Computer Science Collection Computer Science Database Advanced Technologies Database with Aerospace Biological Sciences Computer and Information Systems Abstracts Academic Computer and Information Systems Abstracts Professional Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Publicly Available Content (ProQuest) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database Computer Science Database ProQuest Central Student Technology Collection Technology Research Database Computer and Information Systems Abstracts – Academic ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials ProQuest Computer Science Collection Computer and Information Systems Abstracts ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central Genetics Abstracts Biotechnology Research Abstracts Natural Science Collection ProQuest Central Korea Biological Science Collection Australia & New Zealand Database Advanced Technologies Database with Aerospace Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Technology Collection Biological Science Database ProQuest SciTech Collection Ecology Abstracts Biotechnology and BioEngineering Abstracts Computer and Information Systems Abstracts Professional Advanced Technologies & Aerospace Database ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: AFRWT name: Sage Journals GOLD Open Access 2024 url: http://journals.sagepub.com/ sourceTypes: Publisher – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1176-9343 |
| EndPage | 11769343231212078 |
| ExternalDocumentID | oai_doaj_org_article_57250933c1004406bec93d62e97f8d95 10_1177_11769343231212078 10.1177_11769343231212078 |
| GrantInformation_xml | – fundername: Guangdong Medical Research Foundation grantid: A2023463 funderid: https://doi.org/10.13039/501100003785 – fundername: ; grantid: A2023463 |
| GroupedDBID | --- 0R~ 188 29G 2UF 2WC 31X 3V. 54M 5GY 5VS 8FE 8FG 8FH AAHBH AAKPC AATBZ ABDBF ABQXT ABUWG ACGFS ACROE ACSIQ ADBBV ADOGD ADRAZ AENEX AEWDL AEWHI AFCOW AFKRA AFKRG AFRWT AINHJ AJUZI ALMA_UNASSIGNED_HOLDINGS AOIJS ARAPS AUTPY AYAGU AYAKG BAWUL BBNVY BCNDV BDDNI BENPR BGLVJ BHPHI BPHCQ C1A CCPQU CEFSP CNMHZ DIK DV7 E3Z EBD EBS EJD ESX F5P FRJ GROUPED_DOAJ GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION H13 HCIFZ HYE IAO IFM IHR IPNFZ ITC J8X K.F K6V K7- KQ8 LK8 M48 M7P MK~ ML0 M~E O5R O5S O9- OK1 P2P P62 PIMPY PQQKQ PROAC RIG RNS ROL RPM SFC SFK SFT SGV SPP TR2 TUS UZ5 ~8M AAYXX CITATION 7QO 7SC 7SN 8FD AZQEC C1K DWQXO FR3 GNUQQ JQ2 L7M L~C L~D P64 PQEST PQUKI PRINS RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c462t-9b8a95c67b5f2859ef691ff1d07c0db8ad3fe88b644cb3c2741d8cf2843778213 |
| IEDL.DBID | RPM |
| ISSN | 1176-9343 |
| IngestDate | Fri Oct 04 13:15:32 EDT 2024 Tue Sep 17 21:30:04 EDT 2024 Sat Aug 17 00:57:19 EDT 2024 Fri Sep 13 03:54:36 EDT 2024 Fri Aug 23 00:28:20 EDT 2024 Tue Jul 16 20:50:43 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | biomarker FASTK family prognosis kidney renal clear cell carcinoma Multi-omics analysis |
| Language | English |
| License | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c462t-9b8a95c67b5f2859ef691ff1d07c0db8ad3fe88b644cb3c2741d8cf2843778213 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8690-6097 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683404/ |
| PQID | 2920190531 |
| PQPubID | 1026404 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_57250933c1004406bec93d62e97f8d95 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10683404 proquest_miscellaneous_2896801628 proquest_journals_2920190531 crossref_primary_10_1177_11769343231212078 sage_journals_10_1177_11769343231212078 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-01-01 |
| PublicationDateYYYYMMDD | 2023-01-01 |
| PublicationDate_xml | – month: 01 year: 2023 text: 2023-01-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London, England |
| PublicationPlace_xml | – name: London, England – name: London – name: Sage UK: London, England |
| PublicationTitle | Evolutionary bioinformatics online |
| PublicationYear | 2023 |
| Publisher | SAGE Publications Sage Publications Ltd SAGE Publishing |
| Publisher_xml | – name: SAGE Publications – name: Sage Publications Ltd – name: SAGE Publishing |
| References | Nerich, Hugues, Paillard 2014; 7 Curigliano 2018; 52 Bruchbacher, Lemberger, Hassler, Fajkovic, Schmidinger 2020; 30 Chandrashekar, Bashel, Balasubramanya 2017; 19 Cesana, DeRaffele, Cohen 2006; 24 Delacher, Imbusch, Weichenhan 2017; 18 Bindea, Mlecnik, Tosolini 2013; 39 Wang, Jensen, Zenklusen 2016; 1418 Zhao, Zhao, Cui 2023; 7 Srivastava, Syed, Kumar 2017; 8 Li, Pan, Cao, Zhao 2020; 10 Kang, Boku, Satoh 2017; 390 Motzer, Bukowski, Figlin 2008; 113 Capitanio, Bensalah, Bex 2019; 75 Fang, Zhang, Lu, Jin, Liu 2020; 121 Yuan, Yan, Zhang 2019; 47 Bauer, Kleeff, Bier 2009; 9 Siegel, Miller, Jemal 2017; 67 Szklarczyk, Gable, Lyon 2019; 47 Tang, Kang, Li, Chen, Zhang 2019; 47 Pontén, Jirström, Uhlen 2008; 216 Warde-Farley, Donaldson, Comes 2010; 38 Liotta, Gacci, Frosali 2011; 107 Ricketts, De Cubas, Fan 2018; 23 Simarro, Gimenez-Cassina, Kedersha 2010; 401 Gao, Aksoy, Dogrusoz 2013; 6 Wu, Liu, He 2020; 11 Ru, Wong, Tong 2019; 35 Klauschen, Müller, Binder 2018; 52 Haake, Weyandt, Rathmell 2016; 14 Rini, McDermott, Hammers 2016; 4 Latif, Tory, Gnarra 1993; 260 Colas, Perez, Cabrera 2011; 129 Motzer, Escudier, McDermott 2015; 373 van Doorn, van Kester, Dijkman 2009; 113 Wang, Mi, Debernardi 2015; 6 Woo, Turnis, Goldberg 2012; 72 bibr30-11769343231212078 bibr8-11769343231212078 bibr20-11769343231212078 bibr10-11769343231212078 Zhao JW (bibr22-11769343231212078) 2023; 7 bibr28-11769343231212078 bibr15-11769343231212078 bibr12-11769343231212078 bibr25-11769343231212078 bibr2-11769343231212078 bibr5-11769343231212078 bibr35-11769343231212078 bibr7-11769343231212078 Li Q (bibr18-11769343231212078) 2020; 10 bibr4-11769343231212078 bibr31-11769343231212078 bibr21-11769343231212078 bibr1-11769343231212078 bibr14-11769343231212078 bibr37-11769343231212078 bibr11-11769343231212078 bibr24-11769343231212078 bibr27-11769343231212078 bibr17-11769343231212078 bibr34-11769343231212078 bibr32-11769343231212078 bibr3-11769343231212078 bibr16-11769343231212078 bibr36-11769343231212078 bibr9-11769343231212078 bibr13-11769343231212078 bibr6-11769343231212078 bibr23-11769343231212078 bibr33-11769343231212078 bibr26-11769343231212078 bibr19-11769343231212078 bibr29-11769343231212078 |
| References_xml | – volume: 75 start-page: 74 year: 2019 end-page: 84 article-title: Epidemiology of renal cell carcinoma publication-title: Eur Urol contributor: fullname: Bex – volume: 11 start-page: 992 year: 2020 article-title: Identification of the six-RNA-Binding protein signature for prognosis prediction in bladder cancer publication-title: Front Genet contributor: fullname: He – volume: 7 start-page: 365 year: 2014 end-page: 374 article-title: Clinical impact of targeted therapies in patients with metastatic clear-cell renal cell carcinoma publication-title: Onco Targets Ther contributor: fullname: Paillard – volume: 9 start-page: 34 year: 2009 end-page: 44 article-title: Identification of malignancy factors by analyzing cystic tumors of the pancreas publication-title: Pancreatology contributor: fullname: Bier – volume: 6 start-page: 16527 year: 2015 end-page: 16542 article-title: A six gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia publication-title: Oncotarget contributor: fullname: Debernardi – volume: 373 start-page: 1803 year: 2015 end-page: 1813 article-title: Nivolumab versus everolimus in advanced renal cell carcinoma publication-title: N Engl J Med contributor: fullname: McDermott – volume: 19 start-page: 649 year: 2017 end-page: 658 article-title: UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses publication-title: Neoplasia contributor: fullname: Balasubramanya – volume: 23 year: 2018 article-title: The Cancer Genome Atlas comprehensive molecular characterization of renal cell carcinoma publication-title: Cell Rep contributor: fullname: Fan – volume: 1418 start-page: 111 year: 2016 end-page: 141 article-title: A practical guide to the cancer genome atlas (TCGA) publication-title: Methods Mol Biol contributor: fullname: Zenklusen – volume: 47 year: 2019 article-title: STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets publication-title: Nucleic Acids Res contributor: fullname: Lyon – volume: 52 start-page: 151 year: 2018 end-page: 157 article-title: Scoring of tumor-infiltrating lymphocytes: from visual estimation to machine learning publication-title: Semin Cancer Biol contributor: fullname: Binder – volume: 30 start-page: 534 year: 2020 end-page: 541 article-title: PD1/PD-L1 therapy in metastatic renal cell carcinoma publication-title: Curr Opin Urol contributor: fullname: Schmidinger – volume: 10 year: 2020 article-title: Comprehensive analysis of prognostic value and immune infiltration of chromobox family members in colorectal cancer publication-title: Front Oncol contributor: fullname: Zhao – volume: 260 start-page: 1317 year: 1993 end-page: 1320 article-title: Identification of the von HippelLindau disease tumor suppressor gene publication-title: Science contributor: fullname: Gnarra – volume: 113 start-page: 127 year: 2009 end-page: 136 article-title: Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome publication-title: Blood contributor: fullname: Dijkman – volume: 14 start-page: 589 year: 2016 end-page: 598 article-title: Insights into the genetic basis of the renal cell carcinomas from the cancer genome atlas publication-title: Mol Cancer Res contributor: fullname: Rathmell – volume: 4 start-page: 81 year: 2016 article-title: Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of renal cell carcinoma publication-title: J Immunother Cancer contributor: fullname: Hammers – volume: 47 year: 2019 article-title: CancerSEA: a cancer single-cell state atlas publication-title: Nucleic Acids Res contributor: fullname: Zhang – volume: 113 start-page: 1552 year: 2008 end-page: 1558 article-title: Prognostic nomogram for sunitinib in patients with metastatic renal cell carcinoma publication-title: Cancer contributor: fullname: Figlin – volume: 24 start-page: 1169 year: 2006 end-page: 1177 article-title: Characterization of Cd4(+)Cd25(+) regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma publication-title: J Clin Oncol contributor: fullname: Cohen – volume: 35 start-page: 4200 year: 2019 end-page: 4202 article-title: TISIDB: an integrated repository portal for tumor-immune system interactions publication-title: Bioinformatics contributor: fullname: Tong – volume: 7 start-page: 123 year: 2023 end-page: 130 article-title: The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity publication-title: Clin Transl Oncol contributor: fullname: Cui – volume: 67 start-page: 7 year: 2017 end-page: 30 article-title: Cancer statistics, 2017 publication-title: CA Cancer J Clin contributor: fullname: Jemal – volume: 121 start-page: 2458 year: 2020 end-page: 2466 article-title: FASTKD2 promotes cancer cell progression through upregulating Myc expression in pancreatic ductal adenocarcinoma publication-title: J Cell Biochem contributor: fullname: Liu – volume: 18 start-page: 1160 year: 2017 end-page: 1172 article-title: Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues publication-title: Nat Immunol contributor: fullname: Weichenhan – volume: 52 start-page: 253 year: 2018 end-page: 258 article-title: Gyneco-oncological genomics and emerging biomarkers for cancer treatment with immune-checkpoint inhibitors publication-title: Semin Cancer Biol contributor: fullname: Curigliano – volume: 129 start-page: 2435 year: 2011 end-page: 2444 article-title: Molecular markers of endometrial carcinoma detected in uterine aspirates publication-title: Int J Cancer contributor: fullname: Cabrera – volume: 72 start-page: 917 year: 2012 end-page: 927 article-title: Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-Cell function to promote tumoral immune escape publication-title: Cancer Res contributor: fullname: Goldberg – volume: 216 start-page: 387 year: 2008 end-page: 393 article-title: The human protein atlas: a tool for pathology publication-title: J Pathol contributor: fullname: Uhlen – volume: 6 start-page: 1 year: 2013 article-title: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal publication-title: Sci Signal contributor: fullname: Dogrusoz – volume: 39 start-page: 782 year: 2013 end-page: 795 article-title: Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer publication-title: Immunity contributor: fullname: Tosolini – volume: 401 start-page: 440 year: 2010 end-page: 446 article-title: Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration publication-title: Biochem Biophys Res Commun contributor: fullname: Kedersha – volume: 38 year: 2010 article-title: The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function publication-title: Nucleic Acids Res contributor: fullname: Comes – volume: 47 year: 2019 article-title: GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis publication-title: Nucleic Acids Res contributor: fullname: Zhang – volume: 390 start-page: 2461 year: 2017 end-page: 2471 article-title: Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial publication-title: Lancet contributor: fullname: Satoh – volume: 8 start-page: 117 year: 2017 end-page: 127 article-title: Fas-activated serine/threonine kinase: structure and function publication-title: Gene Rep contributor: fullname: Kumar – volume: 107 start-page: 1500 year: 2011 end-page: 1506 article-title: Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma publication-title: BJU Int contributor: fullname: Frosali – ident: bibr37-11769343231212078 doi: 10.1016/S0140-6736(17)31827-5 – ident: bibr19-11769343231212078 doi: 10.1007/978-1-4939-3578-9_6 – ident: bibr12-11769343231212078 doi: 10.1159/000178873 – ident: bibr11-11769343231212078 doi: 10.1016/j.genrep.2017.07.001 – ident: bibr13-11769343231212078 doi: 10.1182/blood-2008-04-153031 – ident: bibr29-11769343231212078 doi: 10.1093/nar/gkz430 – ident: bibr20-11769343231212078 doi: 10.1016/j.neo.2017.05.002 – volume: 7 start-page: 123 year: 2023 ident: bibr22-11769343231212078 publication-title: Clin Transl Oncol contributor: fullname: Zhao JW – ident: bibr33-11769343231212078 doi: 10.1200/JCO.2005.03.6830 – ident: bibr10-11769343231212078 doi: 10.1016/j.bbrc.2010.09.075 – ident: bibr4-11769343231212078 doi: 10.1158/1541-7786.MCR-16-0115 – ident: bibr16-11769343231212078 doi: 10.1002/jcb.29468 – ident: bibr25-11769343231212078 doi: 10.1093/nar/gky1131 – ident: bibr35-11769343231212078 doi: 10.1097/MOU.0000000000000788 – ident: bibr7-11769343231212078 doi: 10.3322/caac.21387 – ident: bibr6-11769343231212078 doi: 10.2147/OTT.S56370 – ident: bibr8-11769343231212078 doi: 10.1056/NEJMoa1510665 – ident: bibr14-11769343231212078 doi: 10.1002/ijc.25901 – ident: bibr26-11769343231212078 doi: 10.1093/nar/gky939 – ident: bibr28-11769343231212078 doi: 10.1093/bioinformatics/btz210 – ident: bibr36-11769343231212078 doi: 10.1158/0008-5472.CAN-11-1620 – ident: bibr21-11769343231212078 doi: 10.1002/path.2440 – ident: bibr27-11769343231212078 doi: 10.1016/j.immuni.2013.10.003 – ident: bibr31-11769343231212078 doi: 10.1016/j.semcancer.2018.07.001 – ident: bibr5-11769343231212078 doi: 10.1002/cncr.23776 – volume: 10 year: 2020 ident: bibr18-11769343231212078 publication-title: Front Oncol contributor: fullname: Li Q – ident: bibr15-11769343231212078 doi: 10.18632/oncotarget.4113 – ident: bibr30-11769343231212078 doi: 10.1016/j.semcancer.2018.05.004 – ident: bibr2-11769343231212078 doi: 10.1016/j.celrep.2018.06.032 – ident: bibr32-11769343231212078 doi: 10.1038/ni.3799 – ident: bibr23-11769343231212078 doi: 10.1126/scisignal.2004088 – ident: bibr24-11769343231212078 doi: 10.1093/nar/gkq537 – ident: bibr1-11769343231212078 doi: 10.1016/j.eururo.2018.08.036 – ident: bibr9-11769343231212078 doi: 10.1186/s40425-016-0180-7 – ident: bibr34-11769343231212078 doi: 10.1111/j.1464-410X.2010.09555.x – ident: bibr3-11769343231212078 doi: 10.1126/science.8493574 – ident: bibr17-11769343231212078 doi: 10.3389/fgene.2020.00992 |
| SSID | ssj0045176 |
| Score | 2.2981026 |
| Snippet | Objective:
The Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression... Objective: The Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression... ObjectiveThe Fas-activated serine/threonine kinase (FASTK) family of proteins has been recently found to be able to regulate mitochondrial gene expression... |
| SourceID | doaj pubmedcentral proquest crossref sage |
| SourceType | Open Website Open Access Repository Aggregation Database Publisher |
| StartPage | 11769343231212078 |
| SubjectTerms | Biomarkers Carcinoma DNA damage Gene expression Growth factors Immune system Infiltration Kidneys Kinases Macrophages Mast cells Medical prognosis Metastases Original Research Post-transcription Protein-serine/threonine kinase Renal cell carcinoma Survival Transforming growth factor-b |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1dS90wGA5DGOxG9uFYNx0ZCMKg0DRpml7qYQedKDIVvCv51IJLh-d44b0_3Pdtetw5E_FmN6U0Cfl6kzxp3jwPIdvBWSS95LmvTJmLyvFcmyLklmlWc80Rw6K3xbHcPxc_L6qLJakv9AlL9MCp4WDDDos07LrtQG1WSMiz4U6WvqmDck1iL2XVYjOV5mBRsVqOZ5hIrwQP2eAVSs5gqi5QU21pFRrI-lcQ5r_-kUtOXsO6M31L1kfASHdTQd-RVz6-J6-ThOTdB3I_3KDN8W7xjC4YRmgf6MlNjz50kIqedpcRPYKwg6mOjh7gpRBPD2LorkfaXEwy3T09O6RJCoMeeZQKmdEu0sPORX9Hf3ksyAR1JujEX8Mr6hDF_rfeIOfTH2eT_XxUVsitkOU8b4zSTWVlbaqADHY-yIaFwFxR28JBoOPBK2UALFnDLVLcOGUhquA1QArGP5K12Ef_iVDpuDaitkYOcmZM2UowzWsP0EV6EzLyfdHS7Z9EoNGykWP8SbdkZA_74jEicl8PH8Ai2tEi2pcsIiObi55sxwE5a1GUC7APzDgZ-fYYDEMJz0d09P0txFGNhAVbllAOtWIBKwVaDYnd1UDKDbVVXBQiIztoLH9zfrayn_9HZb-QNyXArvRTaJOszW9u_RbApLn5OoyIB359CuQ priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEBZpQqGX0id1mxYVCoWCWct62D6VZMmyaWgIeUBuRs_EkMrp7uaQe394Z_xIsi3txRhLxpJnpBk0M99HyKfgLIJe8tRLk6dCOp5qk4XUMs0Krjn6sJhtcajmZ-LbuTzfIPOxFgbTKsc9sduoXWvxjHyCrEpgvEBlJtrgKYBdTb5e_0yRPwrjrAOZxiOylTOBAdut3b3Do-NxVxaSFWqIaiLgElxUhUWVnMHmnSHL2gO71MH3r_mcf2ZMPkj76izR7Bl5OriQdKeX-XOy4eML8rgnlbx9SX51NbUpVhsv6Yg5QttAjxYtZtXBW_SkuYiYI4Qipzo6uo9lIp7ux9BcDUC6-Mps5-T0gPbkGPS7R_KQJW0iPWhc9Lf02ONApsg8Qaf-Cm6RmSi2P_QrcjbbO53O04FrIbVC5au0MqWupFWFkQEx7XxQFQuBuaywmYNGx4MvSwPukzXcIuiNKy10FbwAJ4Px12QzttG_IVQ5ro0orFEdwRkrrRRM88KDM6O8CQn5Mv7p-rqH1KjZgDr-l1gSsouyuOuIaNjdg3ZxUQ-Lq5YFOHIV57aDv8sU6GXFncp9VYTSVTIh26Mk62GJLut7hUrIx7tmWFwYMdHRtzfQp6wUmHCVwzjKNQ1YG9B6S2wuO5humG3JRSYS8hmV5f7L_5zs2_-P8x15gmT3_QHQNtlcLW78e3CJVubDoO2_AV2TCMQ priority: 102 providerName: ProQuest – databaseName: Sage Journals GOLD Open Access 2024 dbid: AFRWT link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bi9QwFA7rLIIv4hWrq0QQBCFu07Rp8yTj4LDrosjuLO5baW67hZ1U5vIw7_5wz-lltV7Al1KalKTNSfKRc873EfLKW4Okl4K5TCcszaxglY49M7ziuagEYliMtvgsj87TjxfZxR5phlyY_g-u32JYFfSoXaxxduNp9GHvZDyEi1SYEik4LL2wy73bbpZld9w9qGrgE_RPb5fo2jYYELljQ3rbLbKfICvuhOxP56dfF8PinWa81aPDBhi20DtC_9roaCtrGf9HMPX3IMtfIsXazWt-j9ztUSeddmZyn-y58IDc7nQodw_J9zYNl2GC8poONCW08fTLqsFAPHiLntWXAcOK0EpoFSw9xswSR4-Dr6977l18ZT49W5zQTk-DfnKoN7KmdaAntQ1uR08ddmSGYhV05q7hFsWMQrOsHpHz-YfF7Ij18gzMpDLZMKWLSmVG5jrzSIPnvFTce27j3MQWCq3wrig0IC6jhUGeHFsYqJqKHHAJF4_JJDTBPSFUWlHpNDdatppovDBZyiuRO8A_0mkfkTfDny6_dSwcJe-Jyv8Yloi8x7G4qYgE2u2DZnVZ9vOxzHLAfkoI0zLmxRJMWQkrE6dyX1iVReRgGMlysMkSlb0AQMGyFZGXN8UwH9HJUgXXbKFOoSTs-jKBfhQjCxh1aFwS6quW2Ru-thBpnEbkNRrLz5b_-bFP_7vmM3InAYDWHR8dkMlmtXXPAVBt9It-EvwAtyUZLg priority: 102 providerName: SAGE Publications – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9UwFA9zIvgizg-szhFBEIRq26Rp-iAyL7tsjom4XdhbyedWuKZ67x143_3DPacf11WnL6U0CU1yTpJfm5Pfj5CX3hokvWSxy3UW89yyWOnExyZVacEUQwyL0RafxOGMfzzPz7fIIG_Vd-Dyxk871JOaLeZvfnxfv4cB_67fcnwLF1HiAUmWwkQMa94tcjvjjKPDn_DNpgLPIV-_sXljsdHS1DL4j2Dnn0GT1yK_2sVoep_c61Ek3e_MvkO2XHhA7nS6kuuH5Gd7rDbGA8dLOtCO0MbTz4sGA-ugFD2tLwKGCaHVqQqWHuFJEUePgq_nPZcuFpnun54d004fg5441A9Z0jrQ49oGt6ZfHFZkguITdOLmcIviRKH5qh6R2fTgbHIY93ILseEiW8WllqrMjSh07pHWznlRpt6nNilMYiHRMu-k1ICgjGYGeW-sNJCVswJwRsoek-3QBPeEUGGZ0rwwWrQaZ6k0OU8VKxzgGeG0j8jroaerbx2rRpX2xON_mSUiH9AWm4xIiN0-aBYXVT--qrwALFcyZloGvESAa5bMisyVhZe2zCOyO1iyGpysQqUuAEQwDUXkxSYZxhdumqjgmivII0sBq7jIoB5y5AGjCo1TQn3ZMnVDayXjCY_IK3SW32_-Z2Of_r-ez8hd1Lvv_gHtku3V4so9B1S00nutr_8CcrgGhQ priority: 102 providerName: Scholars Portal |
| Title | Multi-omics Analysis of Prognostic Significance and Immune Infiltration of FASTK Family Members in Kidney Renal Clear Cell Carcinoma |
| URI | https://journals.sagepub.com/doi/full/10.1177/11769343231212078 https://www.proquest.com/docview/2920190531/abstract/ https://search.proquest.com/docview/2896801628 https://pubmed.ncbi.nlm.nih.gov/PMC10683404 https://doaj.org/article/57250933c1004406bec93d62e97f8d95 |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pa9swFBZNx2CXsZ_MWxc0GAwGbuzIluVjGpq1KykhTVlvxvrVGhK5JOmh9_3he0-2u2Zjl11sY8lI9nuSPtvvfR8hn61WSHrJQpPKYZikmoWljGyo4jLOWMkQw2K0xTk_uUy-X6VXe4R3uTA-aF_J6tAtV4euuvGxlbcrNejixAaz6RheYwRLomTQI72Mse4dvZl_kzTOePv_EqmVYMNzTJ9kMUzTEeqpPVqBPFH_Drr8MzbyUYCXX3MmL8jzFizSUdOpl2TPuFfkaSMfef-a_PTZsyHmFW9oxy5Ca0tn6xrj5-AqelFdO4wGQuPS0ml6igkhhp46Wy1byly8ZDK6WJzRRgaDTg3KhGxo5ehZpZ25p3ODHRmjxgQdmyUcogaRq1flG3I5OV6MT8JWVSFUCR9uw1yKMk8Vz2Rqkb3OWJ7H1sY6ylSkoVAza4SQAJSUZArpbbRQUDVhGcCJmL0l-6525h2hXLNSJpmS3EuZxUKlSVyyzABs4UbagHztnnRx25BnFHHLL_6XWQJyhLZ4qIi81_5Evb4uWusXaQaQLWdMeaK7iIMH5kzzockzK3SeBuSgs2TRDsZNgYJcgHtgtgnIp4diGEb4b6R0pr6DOiLnsFjzIfRD7HjATod2S8A_PSF3548B-YLO8rvlf97s-_9v5AN5hpL3zWegA7K_Xd-ZjwCMtrJPemLyrU-ejCbzHwvYHx2fz-Z9_5kBttNE9P1I-QXRbRFL |
| link.rule.ids | 230,315,733,786,790,870,891,2115,12792,21416,21994,24346,27886,27957,27958,33408,33779,33780,43635,43840,44980,45368,53827,53829 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9RAEF-0IvoifmJq1RUEQQhmbzeb5Enq4XnntUXsFfoW9rMG6qa9uz703T_cmWTT9hR9CSG7IbOZ2Z1hd-b3I-SttwZBL3nqcj1KRW55qnTmU8MUK7jiGMNitsWBnB6Jr8f5cdxwW8W0ymFN7BZq2xrcI_-ArErgvMBkPp6dp8gahaerkULjNrkjOLhOrBSffBlWYpGzQsaTTARZgoussJCSM1iwM2RWu-GLOsj-jTjzzyzJG6lenfeZPCQPYthId3s9PyK3XHhM7vZEkpdPyK-ujjbFCuMVHXBGaOvpt2WLmXTwFj1sTgLmBaGaqQqWzrA0xNFZ8M1pBM_FVya7h4s57Qkx6L5DwpAVbQKdNza4S_rdoSBjZJugY3cKt8hGFNqf6ik5mnxejKdp5FdIjZCjdVrpUlW5kYXOPeLYOS8r5j2zWWEyC42We1eWGkImo7lBoBtbGugqeAGBBePPyFZog3tOqLRcaVEYLTtSM1aaXDDFCwcBjHTaJ-T98Kfrsx5Go2YRafwvtSTkE-riqiMiYHcP2uVJHSdUnRcQvFWcmw7yLpNgixW3cuSqwpe2yhOyM2iyjtNyVV8bUULeXDXDhMJTEhVcewF9ykqC25YjkKPcsIANgTZbQvOjg-aG0ZZcZCIh79BYrr_8z8Fu_1_O1-TedLG_V-_NDuYvyH0ku-83gHbI1np54V5CSLTWrzq7_w3CewaR |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLVgCMQL94nCACMhISGljePEiR9HoVopmyq2SZN4iOLbiGidqpeH8cwP5_tyGesQL3uJothWbPmzcxwfn0PIO2c0il7ywCYqCuLE8KBQoQs0K1jKC44YFtkWR-LgNP5ylpy1rMpVS6v0WpV9P5v3ffmj5lYu5nrQ8cQG08MhLGMyHofxYGHc4Da5A4M2kt1KvZmF44Slot3FRIEluAiJhyg5g8k6RFe1K9-hWq5_C2NeZ0heoXnVX57RQ_K9q3NDOPnZ36xVX_-6Jud4s0Y9Ig9aQEr3mzyPyS3rn5C7jUXlxVPyuz6hG-DZ5RXtFExo5eh0WSFHD0rR4_LcI-MIA4gW3tAxHjqxdOxdOWtlebHIaP_4ZEIbqw16aNGKZEVLTyel8faCfrNYkSH6WNChncEt-hz5al48I6ejzyfDg6B1bgh0LKJ1IFVWyESLVCUOFfKsE5I5x0yY6tBAouHOZpkCMKYV1yihYzINWWOeAmRhfJfs-Mrb54QKwwsVp1qJ2i6NZTqJWcFTC9BIWOV65EPXj_miEejIWath_k-n98hH7OnLjKitXT-olud52xl5kgIslJzrWkwvFBDlkhsRWZm6zMikR_a6OMnbAb_K0fQLsBXMaD3y9jIZhiruvxTeVhvIk0kBgEBEUI9sK762KrSdAuFSi3534dEj7zEU_775v419cfOXvCH3pp9G-dfx0eQluR8Brmv-Ou2RnfVyY18BDlur1_WA-wOtCi_4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multi-omics+Analysis+of+Prognostic+Significance+and+Immune+Infiltration+of+FASTK+Family+Members+in+Kidney+Renal+Clear+Cell+Carcinoma&rft.jtitle=Evolutionary+bioinformatics+online&rft.au=Zhong+Guanghui&rft.au=Wu%2C+Dali&rft.au=Chen%2C+Haiping&rft.au=Yan+Lingfei&rft.date=2023-01-01&rft.pub=Sage+Publications+Ltd&rft.eissn=1176-9343&rft.volume=19&rft_id=info:doi/10.1177%2F11769343231212078 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1176-9343&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1176-9343&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1176-9343&client=summon |