Presynaptic Calcium Dynamics and Transmitter Release Evoked by Single Action Potentials at Mammalian Central Synapses

• Published in: Biophysical journal Vol. 72; no. 2; pp. 637 - 651
• Main Authors: Sinha, Saurabh R., Wu, Ling-Gang, Saggau, Peter
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.1997
• Subjects: Action Potentials - physiology; Animals; Biophysical Theory and Modeling; Cadmium - pharmacology; Calcium - metabolism; Calcium Channels - metabolism; Electric Stimulation; Electrophysiology; Fluorescent Dyes - metabolism; Fura-2 - analogs & derivatives; Fura-2 - metabolism; Guinea Pigs; In Vitro Techniques; Ion Channels - metabolism; Ion Channels - physiology; Kinetics; Models, Neurological; Neurotransmitter Agents - metabolism; Pyramidal Cells - metabolism; Synapses - metabolism; Synaptic Transmission - physiology

The relationship between presynaptic calcium transients ([Ca 2+] t) and transmitter release evoked by a single stimulus was both investigated experimentally and modeled at a mammalian central synapse, the CA3 to CA1 pyramidal cell synapse in guinea pig hippocampal slices. In the present study, we co...