Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy

• Published in: Frontiers in endocrinology (Lausanne) Vol. 10; p. 245
• Main Authors: Rani, Aradhana, Stebbing, Justin, Giamas, Georgios, Murphy, John
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.05.2019
• Subjects: breast cancer; endocrine resistance; Endocrinology; estrogen (E2); estrogen receptor; signaling; breast cancer; signaling; endocrine resistance; estrogen receptor; estrogen (E2)

The importance and role of the estrogen receptor (ER) pathway has been well-documented in both breast cancer (BC) development and progression. The treatment of choice in women with metastatic breast cancer (MBC) is classically divided into a variety of endocrine therapies, 3 of the most common being...