Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing

• Published in: Stem cell research Vol. 34; p. 101360
• Main Authors: Huo, Zijun, Tu, Jian, Xu, An, Li, Yan, Wang, Donghui, Liu, Mo, Zhou, Ruoji, Zhu, Dandan, Lin, Yu, Gingold, Julian A., Yen, Chia-Jui, Xiao, Haipeng, Zhao, Ruiying
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.01.2019; Elsevier

As one of the most essential genome guardians, p53 and its mutants have been suggested associated with many types of cancers. Many p53 mutants function induce unique phenotypes, including carcinogenesis, metastasis, and drug resistance. The p53(R249S) mutation is the most prevalent and specific muta...