Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury

• Published in: Nature communications Vol. 14; no. 1; pp. 7598 - 15
• Main Authors: Shan, Xinyi, Li, Jiahuan, Liu, Jiahao, Feng, Baoli, Zhang, Ting, Liu, Qian, Ma, Huixin, Wu, Honghong, Wu, Hao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 13/51; 14/19; 631/154; 692/699; Acetaminophen; Antioxidants; Biocompatibility; Cell death; Coatings; Ferroptosis; Health services; Humanities and Social Sciences; Injuries; Iron; Ischemia; Lipid peroxidation; Lipids; Liver; Liver diseases; Lysosomes; Manganese oxides; multidisciplinary; Nanoparticles; Oxygen; Pathogenesis; Peroxidation; Polyacrylic acid; Reactive oxygen species; Reperfusion; Science; Science (multidisciplinary); Synthesis; TOR protein

Ferroptosis, a newly characterized form of regulated cell death, is induced by excessive accumulation of lipid peroxidation catalyzed by intracellular bioactive iron. Increasing evidence has suggested that ferroptosis is involved in the pathogenesis of several human diseases, including acute liver i...