Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target

• Published in: Frontiers in microbiology Vol. 10; p. 1701
• Main Authors: Galdino, Anna Clara M, Viganor, Lívia, de Castro, Alexandre A, da Cunha, Elaine F F, Mello, Thaís P, Mattos, Larissa M, Pereira, Marcos D, Hunt, Mary C, O'Shaughnessy, Megan, Howe, Orla, Devereux, Michael, McCann, Malachy, Ramalho, Teodorico C, Branquinha, Marta H, Santos, André L S
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.08.2019
• Subjects: 1,10-phenanthroline-5,6-dione; anti-virulence therapy; elastase B; metal-based compounds; Microbiology; Pseudomonas aeruginosa; theoretical calculations; Pseudomonas aeruginosa; theoretical calculations; 1,10-phenanthroline-5,6-dione; metal-based compounds; anti-virulence therapy; elastase B

Elastase B (lasB) is a multifunctional metalloenzyme secreted by the gram-negative pathogen , and this enzyme orchestrates several physiopathological events during bacteria-host interplays. LasB is considered to be a potential target for the development of an innovative chemotherapeutic approach, es...