Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

• Published in: Frontiers in immunology Vol. 9; p. 3176
• Main Authors: Patente, Thiago A., Pinho, Mariana P., Oliveira, Aline A., Evangelista, Gabriela C. M., Bergami-Santos, Patrícia C., Barbuto, José A. M.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.01.2019
• Subjects: Animals; Biomarkers; cancer combination therapies; Cancer Vaccines; Cell Differentiation; Combined Modality Therapy; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - metabolism; human dendritic cells; Humans; Immune System - immunology; Immune System - metabolism; Immune System Phenomena; Immunology; Immunotherapy; mo-DC; monocyte-derived dendritic cells; Neoplasms - immunology; Neoplasms - pathology; Neoplasms - therapy; Phenotype; Treatment Outcome; Tumor Microenvironment - immunology; cancer combination therapies; mo-DC; cancer vaccines; monocyte-derived dendritic cells; human dendritic cells; DC

Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic conditions. Their phenotypic and functional heterogeneity poi...