Afferent Input Modulates Neurotrophins and Synaptic Plasticity in the Spinal Cord

• Published in: Journal of neurophysiology Vol. 92; no. 6; pp. 3423 - 3432
• Main Authors: Gomez-Pinilla, Fernando, Ying, Zhe, Roy, Roland R, Hodgson, John, Edgerton, V. Reggie
• Format: Journal Article
• Language: English
• Published: United States Am Phys Soc 01.12.2004
• Subjects: Animals; Botulinum Toxins, Type A - pharmacology; Brain-Derived Neurotrophic Factor - genetics; Female; GAP-43 Protein - genetics; Gene Expression - physiology; In Vitro Techniques; Muscle, Skeletal - drug effects; Muscle, Skeletal - innervation; Neuromuscular Agents - pharmacology; Neuronal Plasticity - physiology; Neurons, Afferent - physiology; Neurotrophin 3 - genetics; Rats; Rats, Sprague-Dawley; RNA, Messenger - metabolism; Spinal Cord - cytology; Spinal Cord - physiology; Synapsins - genetics

1 Department of Physiological Science, 2 Division of Neurosurgery, UCLA Brain Injury Research Center, and 3 Brain Research Institute, UCLA, Los Angeles, California 90095 Submitted 27 April 2004; accepted in final form 4 August 2004 The effects of eliminating or decreasing neuromuscular activity on t...