Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma

• Published in: Oncotarget Vol. 5; no. 22; pp. 11103 - 11120
• Main Authors: Qi, Xiang, Ng, Kevin Tak Pan, Lian, Qi Zhou, Liu, Xiao Bing, Li, Chang Xian, Geng, Wei, Ling, Chang Chun, Ma, Yuen Yuen, Yeung, Wai Ho, Tu, Wen Wei, Fan, Sheung Tat, Lo, Chung Mau, Man, Kwan
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 30.11.2014
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; Cell Line, Tumor; Cell Proliferation - physiology; Clinical Research Paper; Down-Regulation; Female; Genes, Tumor Suppressor; Glutathione Peroxidase - administration & dosage; Glutathione Peroxidase - biosynthesis; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Humans; Liver Neoplasms - enzymology; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver Neoplasms - therapy; Male; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stromal Cells - enzymology; Mice; Mice, Nude; Middle Aged; Oxidative Stress - drug effects; Oxidative Stress - physiology; Pluripotent Stem Cells - enzymology; Prognosis; Recombinant Proteins - pharmacology; Xenograft Model Antitumor Assays; Young Adult

We aimed to investigate the clinical significance of GPx3 in hepatocellular carcinoma (HCC) and to characterize its tumor suppressive role. HCC patients (113) who underwent hepatectomy were recruited to examine the clinical relevance of GPx3. The tumor suppressive role of GPx3 was studied by adminis...