BRCAPRO Validation, Sensitivity of Genetic Testing of BRCA1/BRCA2, and Prevalence of Other Breast Cancer Susceptibility Genes

• Published in: Journal of clinical oncology Vol. 20; no. 11; pp. 2701 - 2712
• Main Authors: Berry, Donald A., Iversen, Edwin S., Gudbjartsson, Daniel F., Hiller, Elaine H., Garber, Judy E., Peshkin, Beth N., Lerman, Caryn, Watson, Patrice, Lynch, Henry T., Hilsenbeck, Susan G., Rubinstein, Wendy S., Hughes, Kevin S., Parmigiani, Giovanni
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 01.06.2002; Lippincott Williams & Wilkins
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast Neoplasms - epidemiology; Breast Neoplasms - genetics; Breast Neoplasms - prevention & control; Breast Neoplasms, Male - epidemiology; Breast Neoplasms, Male - genetics; Breast Neoplasms, Male - prevention & control; Decision Making, Computer-Assisted; Female; Genes, BRCA1; Genes, BRCA2; Genetic Carrier Screening; Genetic Predisposition to Disease - epidemiology; Genetic Testing - methods; Gynecology. Andrology. Obstetrics; Humans; Male; Mammary gland diseases; Medical sciences; Middle Aged; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - prevention & control; Pedigree; Prevalence; Probability; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Tumors; United States - epidemiology; United States; North America; America; Human; Validation; Prevalence; Malignant tumor; Medical screening; Epidemiology; Mammary gland diseases; Biomedical data processing; Sensitivity; Computer program; Predisposition; Genetics; Mammary gland; Mutation; Public health; Computer aid; Tumor suppressor gene

PURPOSE: To compare genetic test results for deleterious mutations of BRCA1 and BRCA2 with estimated probabilities of carrying such mutations; to assess sensitivity of genetic testing; and to assess the relevance of other susceptibility genes in familial breast and ovarian cancer. PATIENTS AND METHO...