Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo

• Published in: Neurobiology of disease Vol. 161; p. 105560
• Main Authors: Hang, Liting, Wang, Ziyin, Foo, Aaron S.C., Goh, Geraldine W.Y., Choong, Huey Ching, Thundyil, John, Xu, Shengli, Lam, Kong-Peng, Lim, Kah-Leong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021; Elsevier
• Subjects: Adenylate Kinase - genetics; Adenylate Kinase - metabolism; AMPK; Animals; Dopaminergic Neurons - metabolism; Mice; Mitochondria; Parkinson Disease - metabolism; Parkinson's disease; Phenotype; Substantia Nigra - metabolism; ACC; Parkinson's disease; cKO; SNpc; 6-OHDA; PGC-1α; MFF; Drp1; Mitochondria; PINK1; Mfn; Opa1; PD; TH; TOM20; AMPK; mROS; DA; WT

Emerging studies implicate energy dysregulation as an underlying trigger for Parkinson's disease (PD), suggesting that a better understanding of the molecular pathways governing energy homeostasis could help elucidate therapeutic targets for the disease. A critical cellular energy regulator is...