Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target

• Published in: Frontiers in molecular biosciences Vol. 4; p. 64
• Main Authors: Watson, Gabrielle M., Lucas, William A. H., Gunzburg, Menachem J., Wilce, Jacqueline A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.09.2017
• Subjects: BC loop; Grb7; inhibitor specificity; Molecular Biosciences; peptide inhibitor; SH2 domain; Grb7; SH2 domain; BC loop; inhibitor specificity; peptide inhibitor

Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote proliferative and migratory signaling. Here, we investigate...