Lnc-C/EBPβ Modulates Differentiation of MDSCs Through Downregulating IL4i1 With C/EBPβ LIP and WDR5

• Published in: Frontiers in immunology Vol. 10; p. 1661
• Main Authors: Gao, Yunhuan, Shang, Wencong, Zhang, Dan, Zhang, Shiwu, Zhang, Xipeng, Zhang, Yuan, Yang, Rongcun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.07.2019
• Subjects: H3K4me3; IL4il; Immunology; lncRNA; MDSC; WDR5; WDR5; MDSC; lncRNA; IL4il; H3K4me3

Myeloid-derived suppressor cells (MDSCs), which play an important role in tumor and inflammatory diseases, are divided into two subsets CD11b Ly6C Ly6G monocytic MDSC (Mo-MDSC) and CD11b Ly6C Ly6G polymorphonuclear MDSC (PMN-MDSC) with different immunosuppressive function. However, it is poorly unde...