Local immunity by tissue-resident CD8(+) memory T cells

Microbial infection primes a CD8(+) cytotoxic T cell response that gives rise to a long-lived population of circulating memory cells able to provide protection against systemic reinfection. Despite this, effective CD8(+) T cell surveillance of barrier tissues such as skin and mucosa typically wanes...

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Bibliographic Details
Published inFrontiers in immunology Vol. 3; p. 340
Main Authors Gebhardt, Thomas, Mackay, Laura K
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2012
Subjects
Immunology
Memory
periphery
protection
T cell
Virus infection
protection
memory
periphery
T cell
virus infection
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Summary:Microbial infection primes a CD8(+) cytotoxic T cell response that gives rise to a long-lived population of circulating memory cells able to provide protection against systemic reinfection. Despite this, effective CD8(+) T cell surveillance of barrier tissues such as skin and mucosa typically wanes with time, resulting in limited T cell-mediated protection in these peripheral tissues. However, recent evidence suggests that a specialized subset of CD103(+) memory T cells can permanently lodge and persist in peripheral tissues, and that these cells can compensate for the loss of peripheral immune surveillance by circulating memory T cells. Here, we review evolving concepts regarding the generation and long-term persistence of these tissue-resident memory T cells (T(RM)) in epithelial and neuronal tissues. We further discuss the role of T(RM) cells in local infection control and their contribution to localized immune phenomena, in both mice and humans.
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This article was submitted to Frontiers in Immunological Memory, a specialty of Frontiers in Immunology.
Reviewed by: Kim Klonowski, University of Georgia, USA; Benedita Rocha, INSERM, France; David J. Topham, University of Rochester, USA
Edited by: Gabrielle Belz, Walter and Eliza Hall Institute of Medical Research, Australia
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2012.00340