ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet
The methylation levels of in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of depending on obesity, menopausal state and dietary pattern in blood l...
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| Published in | Frontiers in endocrinology (Lausanne) Vol. 11; p. 245 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | The methylation levels of
in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of
depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of
of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [
= 90;
= 64 (71.1%) overweight/obesity and
= 26 (28.9%) normal-weight] and paired tumor tissue biopsies (
= 8 breast cancer patients with obesity;
= 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the
. The methylation levels of
were correlated between paired leukocytes and breast tumor biopsies (
= 0.62;
= 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity (
= 0.002) and postmenopausal patients (
= 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of
methylation were also found in women with greater adherence to the Mediterranean diet (
= 0.017) or specific foods. Relevantly, the methylation levels of
showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72;
= 0.016]. In conclusion, the association between methylation of
and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of
methylation in the association between breast cancer, adiposity and dietary patterns. |
|---|---|
| AbstractList | The methylation levels of
ZNF577
in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of
ZNF577
depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of
ZNF577
of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [
n
= 90;
n
= 64 (71.1%) overweight/obesity and
n
= 26 (28.9%) normal-weight] and paired tumor tissue biopsies (
n
= 8 breast cancer patients with obesity;
n
= 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the
Sociedad Española de Nutricion Comunitaria
. The methylation levels of
ZNF577
were correlated between paired leukocytes and breast tumor biopsies (
r
= 0.62;
p
= 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity (
p
= 0.002) and postmenopausal patients (
p
= 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of
ZNF577
methylation were also found in women with greater adherence to the Mediterranean diet (
p
= 0.017) or specific foods. Relevantly, the methylation levels of
ZNF577
showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72;
p
= 0.016]. In conclusion, the association between methylation of
ZNF577
and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of
ZNF577
methylation in the association between breast cancer, adiposity and dietary patterns. The methylation levels of ZNF577 in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of ZNF577 depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of ZNF577 of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [n = 90; n = 64 (71.1%) overweight/obesity and n = 26 (28.9%) normal-weight] and paired tumor tissue biopsies (n = 8 breast cancer patients with obesity; n = 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the Sociedad Española de Nutricion Comunitaria. The methylation levels of ZNF577 were correlated between paired leukocytes and breast tumor biopsies (r = 0.62; p = 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity (p = 0.002) and postmenopausal patients (p = 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of ZNF577 methylation were also found in women with greater adherence to the Mediterranean diet (p = 0.017) or specific foods. Relevantly, the methylation levels of ZNF577 showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72; p = 0.016]. In conclusion, the association between methylation of ZNF577 and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of ZNF577 methylation in the association between breast cancer, adiposity and dietary patterns. The methylation levels of in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [ = 90; = 64 (71.1%) overweight/obesity and = 26 (28.9%) normal-weight] and paired tumor tissue biopsies ( = 8 breast cancer patients with obesity; = 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the . The methylation levels of were correlated between paired leukocytes and breast tumor biopsies ( = 0.62; = 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity ( = 0.002) and postmenopausal patients ( = 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of methylation were also found in women with greater adherence to the Mediterranean diet ( = 0.017) or specific foods. Relevantly, the methylation levels of showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72; = 0.016]. In conclusion, the association between methylation of and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of methylation in the association between breast cancer, adiposity and dietary patterns. |
| Author | Lorenzo, Paula M Diaz-Lagares, Angel Crujeiras, Ana B Izquierdo, Andrea G Casanueva, Felipe F Cueva, Juan Sandoval, Juan Carreira, Marcos C Lopez-Lopez, Rafael Macias-Gonzalez, Manuel |
| AuthorAffiliation | 5 Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and Santiago de Compostela University (USC) , Santiago de Compostela , Spain 6 Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, University of Malaga (IBIMA) and CIBEROBN , Málaga , Spain 7 Biomarkers and Precision Medicine Unit and Epigenomics Core Facility, Health Research Institute La Fe , Valencia , Spain 1 Laboratory of Epigenomics in Endocrinology and Nutrition (EpiEndoNut), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) , Santiago de Compostela , Spain 2 CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEOBN), Instituto de Salud Carlos III , Madrid , Spain 8 Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), Uni |
| AuthorAffiliation_xml | – name: 8 Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago (CHUS/SERGAS) , Santiago de Compostela , Spain – name: 4 CIBER de Oncologia (CIBERONC), Instituto de Salud Carlos III , Madrid , Spain – name: 5 Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and Santiago de Compostela University (USC) , Santiago de Compostela , Spain – name: 6 Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, University of Malaga (IBIMA) and CIBEROBN , Málaga , Spain – name: 1 Laboratory of Epigenomics in Endocrinology and Nutrition (EpiEndoNut), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) , Santiago de Compostela , Spain – name: 2 CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEOBN), Instituto de Salud Carlos III , Madrid , Spain – name: 3 Cancer Epigenetics, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago (CHUS/SERGAS) , Santiago de Compostela , Spain – name: 7 Biomarkers and Precision Medicine Unit and Epigenomics Core Facility, Health Research Institute La Fe , Valencia , Spain |
| Author_xml | – sequence: 1 givenname: Paula M surname: Lorenzo fullname: Lorenzo, Paula M organization: Laboratory of Epigenomics in Endocrinology and Nutrition (EpiEndoNut), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Santiago de Compostela, Spain – sequence: 2 givenname: Andrea G surname: Izquierdo fullname: Izquierdo, Andrea G organization: CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEOBN), Instituto de Salud Carlos III, Madrid, Spain – sequence: 3 givenname: Angel surname: Diaz-Lagares fullname: Diaz-Lagares, Angel organization: CIBER de Oncologia (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain – sequence: 4 givenname: Marcos C surname: Carreira fullname: Carreira, Marcos C organization: Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain – sequence: 5 givenname: Manuel surname: Macias-Gonzalez fullname: Macias-Gonzalez, Manuel organization: Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, University of Malaga (IBIMA) and CIBEROBN, Málaga, Spain – sequence: 6 givenname: Juan surname: Sandoval fullname: Sandoval, Juan organization: Biomarkers and Precision Medicine Unit and Epigenomics Core Facility, Health Research Institute La Fe, Valencia, Spain – sequence: 7 givenname: Juan surname: Cueva fullname: Cueva, Juan organization: Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago (CHUS/SERGAS), Santiago de Compostela, Spain – sequence: 8 givenname: Rafael surname: Lopez-Lopez fullname: Lopez-Lopez, Rafael organization: Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago (CHUS/SERGAS), Santiago de Compostela, Spain – sequence: 9 givenname: Felipe F surname: Casanueva fullname: Casanueva, Felipe F organization: Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain – sequence: 10 givenname: Ana B surname: Crujeiras fullname: Crujeiras, Ana B organization: CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEOBN), Instituto de Salud Carlos III, Madrid, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32390948$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2020 Lorenzo, Izquierdo, Diaz-Lagares, Carreira, Macias-Gonzalez, Sandoval, Cueva, Lopez-Lopez, Casanueva and Crujeiras. Copyright © 2020 Lorenzo, Izquierdo, Diaz-Lagares, Carreira, Macias-Gonzalez, Sandoval, Cueva, Lopez-Lopez, Casanueva and Crujeiras. 2020 Lorenzo, Izquierdo, Diaz-Lagares, Carreira, Macias-Gonzalez, Sandoval, Cueva, Lopez-Lopez, Casanueva and Crujeiras |
| Copyright_xml | – notice: Copyright © 2020 Lorenzo, Izquierdo, Diaz-Lagares, Carreira, Macias-Gonzalez, Sandoval, Cueva, Lopez-Lopez, Casanueva and Crujeiras. – notice: Copyright © 2020 Lorenzo, Izquierdo, Diaz-Lagares, Carreira, Macias-Gonzalez, Sandoval, Cueva, Lopez-Lopez, Casanueva and Crujeiras. 2020 Lorenzo, Izquierdo, Diaz-Lagares, Carreira, Macias-Gonzalez, Sandoval, Cueva, Lopez-Lopez, Casanueva and Crujeiras |
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| DOI | 10.3389/fendo.2020.00245 |
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| Keywords | blood cells nutrition cancer biomarkers epigenetics obesity |
| Language | English |
| License | Copyright © 2020 Lorenzo, Izquierdo, Diaz-Lagares, Carreira, Macias-Gonzalez, Sandoval, Cueva, Lopez-Lopez, Casanueva and Crujeiras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Francine Durocher, Centre Hospitalier de l'Université Laval, Canada; Linn Maria Ellinor Gillberg, Copenhagen University Hospital, Denmark Edited by: Bruno Ramos-Molina, Biomedical Research Institute of Murcia (IMIB), Spain This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology |
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in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of... The methylation levels of ZNF577 in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The... The methylation levels of ZNF577 in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The... |
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| Title | ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet |
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