A Biomarker to Differentiate between Primary and Cocaine-Induced Major Depression in Cocaine Use Disorder: The Role of Platelet IRAS/Nischarin (I1-Imidazoline Receptor)

• Published in: Frontiers in psychiatry Vol. 8; p. 258
• Main Authors: Keller, Benjamin, Mestre-Pinto, Joan-Ignasi, Álvaro-Bartolomé, María, Martinez-Sanvisens, Diana, Farre, Magí, García-Fuster, M. Julia, García-Sevilla, Jesús A., Torrens, Marta
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.12.2017
• Subjects: acute tryptophan depletion; cocaine use disorder; cocaine-induced depression; IRAS/nischarin; major depressive disorder; platelet biomarker; Psychiatry; acute tryptophan depletion; cocaine use disorder; major depressive disorder; IRAS/nischarin; antidepressant drugs; cocaine-induced depression; platelet biomarker

The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes. CUD/MDD may be primary (primary MDD) or cocaine-induced (CUD-induced MDD). Specific biomarkers are needed to improve diagnoses and ther...