Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal

• Published in: Frontiers in microbiology Vol. 8; p. 2031
• Main Authors: Darton, Thomas C, Jones, Claire, Dongol, Sabina, Voysey, Merryn, Blohmke, Christoph J, Shrestha, Rajendra, Karkey, Abhilasha, Shakya, Mila, Arjyal, Amit, Waddington, Claire S, Gibani, Malick, Carter, Michael J, Basnyat, Buddha, Baker, Stephen, Pollard, Andrew J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.10.2017
• Subjects: antibody-in-lymphocyte supernatant assay; diagnostic test; enteric fever; febrile illness; Microbiology; Salmonella Paratyphi A; Salmonella Typhi; enteric fever; resource-limited settings; antibody-in-lymphocyte supernatant assay; Salmonella Typhi; diagnostic test; febrile illness; Salmonella Paratyphi A; bacteremia

New diagnostic tests for enteric fever are urgently needed to assist with timely antimicrobial treatment of patients and to measure the efficacy of prevention measures such as vaccination. In a novel translational approach, here we use two recently developed controlled human infection models (CHIM)...