Phospholipase A2 Receptor Autoantibodies as a Novel Serological Biomarker for Autoimmune Thyroid Disease Associated Nephropathy

• Published in: Frontiers in immunology Vol. 11; p. 837
• Main Authors: Huang, Biao, Zhang, Yi, Wang, Liang, Wu, Qingqing, Li, Ting, Zhang, Jue, Zhang, Qiuhua, Sheng, Huiming, Bao, Jiandong, Hu, Zhigang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.04.2020
• Subjects: autoantibodies; Autoantibodies - blood; autoimmune; Biomarkers - blood; Glomerulonephritis, Membranous - immunology; Graves Disease - immunology; Hashimoto Disease - complications; Hashimoto Disease - immunology; Humans; Immunoglobulin G - blood; Immunohistochemistry; Immunology; nephropathy; phospholipase A2 receptor; Receptors, Phospholipase A2 - immunology; Renal Insufficiency, Chronic - etiology; ROC Curve; thyroid disease; thyroid disease; nephropathy; phospholipase A2 receptor; autoimmune; autoantibodies

To develop a highly sensitive immunoassay for PLA2R autoantibodies and study the relationship between PLA2R autoantibodies and autoimmune thyroid disease-associated nephropathy. We applied a highly sensitive time-resolved fluoroimmunoassay to quantitatively detect the concentration of phospholipase...