Signalling to suit function: tailoring phosphoinositide 3-kinase during T-cell activation
Members of the CD28 family of co-receptors are crucial determinants of the outcome of T-cell activation. These receptors interact with ligands in the B7 family and either costimulate or co-inhibit signals through antigen-specific receptors. The T-cell-costimulatory molecules CD28 and inducible costi...
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| Published in | Trends in immunology Vol. 28; no. 4; pp. 161 - 168 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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England
Elsevier Ltd
01.04.2007
Elsevier Limited |
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| Abstract | Members of the CD28 family of co-receptors are crucial determinants of the outcome of T-cell activation. These receptors interact with ligands in the B7 family and either costimulate or co-inhibit signals through antigen-specific receptors. The T-cell-costimulatory molecules CD28 and inducible costimulator recruit and activate class 1A phosphoinositide 3-kinase (PI3K). Interestingly, the co-inhibitory molecules cytotoxic T lymphocyte antigen-4 and B and T lymphocyte attenuator also interact with class 1A PI3K. However, all co-inhibitory receptors share an ability to oppose activation of the key PI3K effector protein kinase B (also known as Akt). Recent evidence suggests that distinct mechanisms exist to limit Akt activation by different co-inhibitory receptors. This article examines how differential positive or negative regulation of the PI3K–Akt signalling pathway by CD28 family receptors enables functional differences between the receptors. |
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| AbstractList | Members of the CD28 family of co-receptors are crucial determinants of the outcome of T-cell activation. These receptors interact with ligands in the B7 family and either costimulate or co-inhibit signals through antigen-specific receptors. The T-cell-costimulatory molecules CD28 and inducible costimulator recruit and activate class 1A phosphoinositide 3-kinase (PI3K). Interestingly, the co-inhibitory molecules cytotoxic T lymphocyte antigen-4 and B and T lymphocyte attenuator also interact with class 1A PI3K. However, all co-inhibitory receptors share an ability to oppose activation of the key PI3K effector protein kinase B (also known as Akt). Recent evidence suggests that distinct mechanisms exist to limit Akt activation by different co-inhibitory receptors. This article examines how differential positive or negative regulation of the PI3K–Akt signalling pathway by CD28 family receptors enables functional differences between the receptors. |
| Author | Parry, Richard V Riley, James L Ward, Stephen G |
| Author_xml | – sequence: 1 fullname: Parry, Richard V – sequence: 2 fullname: Riley, James L – sequence: 3 fullname: Ward, Stephen G |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17336157$$D View this record in MEDLINE/PubMed |
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| Snippet | Members of the CD28 family of co-receptors are crucial determinants of the outcome of T-cell activation. These receptors interact with ligands in the B7 family... |
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| StartPage | 161 |
| SubjectTerms | Allergy and Immunology Animals Humans Immune system Kinases Ligands Lymphocyte Activation - immunology Lymphocytes Phosphatidylinositol 3-Kinases - physiology Phosphorylation Proteins Receptor Cross-Talk - immunology Regulation Signal Transduction - immunology Signal Transduction - physiology T cell receptors T-Lymphocyte Subsets - enzymology T-Lymphocyte Subsets - immunology |
| Title | Signalling to suit function: tailoring phosphoinositide 3-kinase during T-cell activation |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S1471490607000464 https://dx.doi.org/10.1016/j.it.2007.02.004 https://www.ncbi.nlm.nih.gov/pubmed/17336157 https://www.proquest.com/docview/1506940281 https://search.proquest.com/docview/20716259 https://search.proquest.com/docview/70335372 |
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