Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma

• Published in: Oncotarget Vol. 6; no. 15; pp. 13371 - 13386
• Main Authors: Lucarelli, Giuseppe, Galleggiante, Vanessa, Rutigliano, Monica, Sanguedolce, Francesca, Cagiano, Simona, Bufo, Pantaleo, Lastilla, Gaetano, Maiorano, Eugenio, Ribatti, Domenico, Giglio, Andrea, Serino, Grazia, Vavallo, Antonio, Bettocchi, Carlo, Selvaggi, Francesco Paolo, Battaglia, Michele, Ditonno, Pasquale
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 30.05.2015
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell - enzymology; Carcinoma, Renal Cell - pathology; Cell Proliferation - physiology; Chromatography, Liquid; Female; Gas Chromatography-Mass Spectrometry; Glucosephosphate Dehydrogenase - metabolism; Glycolysis - physiology; Humans; Kidney Neoplasms - enzymology; Kidney Neoplasms - pathology; Male; Metabolomics; Middle Aged; NADP - metabolism; Pentose Phosphate Pathway - physiology; Reactive Oxygen Species - metabolism; Real-Time Polymerase Chain Reaction; Research Paper; Tumor Cells, Cultured; renal cell carcinoma; metabolomics; pentose phosphate pathway; G6PDH; glycolysis

The analysis of cancer metabolome has shown that proliferating tumor cells require a large quantities of different nutrients in order to support their high rate of proliferation. In this study we analyzed the metabolic profile of glycolysis and the pentose phosphate pathway (PPP) in human clear cell...