Mucosal Autoimmunity to Cell-Bound GP2 Isoforms Is a Sensitive Marker in PSC and Associated With the Clinical Phenotype

• Published in: Frontiers in immunology Vol. 9; p. 1959
• Main Authors: Sowa, Mandy, Kolenda, Rafał, Baumgart, Daniel C., Pratschke, Johann, Papp, Maria, Tornai, Tamas, Suchanski, Jaroslaw, Bogdanos, Dimitrios P., Mytilinaiou, Maria G., Hammermann, Jutta, Laass, Martin W., Conrad, Karsten, Schramm, Christoph, Franke, Andre, Roggenbuck, Dirk, Schierack, Peter
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.08.2018
• Subjects: cholangiocarcinoma; cirrhosis; immunoglobulin A; Immunology; primary sclerosing cholangitis; zymogen granule glycoprotein 2; immunoglobulin A; zymogen granule glycoprotein 2; cholangiocarcinoma; cirrhosis; primary sclerosing cholangitis

Zymogen granule glycoprotein 2 (GP2) was demonstrated as first autoimmune mucosal target in primary sclerosing cholangitis (PSC) associated with disease severity. Autoantibodies to four GP2 isoforms (aGP2 ) were found in patients with inflammatory bowel diseases but reactivity against specific GP2 e...