Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human

• Published in: Frontiers in genetics Vol. 10; p. 288
• Main Authors: Yuan, Jinbo, Tickner, Jennifer, Mullin, Benjamin H, Zhao, Jinmin, Zeng, Zhiyu, Morahan, Grant, Xu, Jiake
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.04.2019
• Subjects: collaborative cross; Genetics; GWAS; GWLA; osteoporosis; PheWAS; WGS; PheWAS; genome editing; WGS; GWAS; GWLA; collaborative cross; osteoporosis

Osteoporosis is a complex condition with contributions from, and interactions between, multiple genetic loci and environmental factors. This review summarizes key advances in the application of genetic approaches for the identification of osteoporosis susceptibility genes. Genome-wide linkage analys...