Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space

• Published in: Frontiers in immunology Vol. 10; p. 827
• Main Authors: Ogishi, Masato, Yotsuyanagi, Hiroshi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.04.2019
• Subjects: escape mutation; immunogenicity; Immunology; machine learning; T cell epitope; T cell receptor repertoire; T cell receptor repertoire; T cell epitope; escape mutation; machine learning; immunogenicity

Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. T...