Plasma proteoforms of apolipoproteins C-I and C-II are associated with plasma lipids in the Multi-Ethnic Study of Atherosclerosis

• Published in: Journal of lipid research Vol. 63; no. 9; p. 100263
• Main Authors: Koska, Juraj, Furtado, Jeremy, Hu, Yueming, Sinari, Shripad, Budoff, Matthew J., Billheimer, Dean, Nedelkov, Dobrin, McClelland, Robyn L., Reaven, Peter
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2022; Elsevier
• Subjects: Apolipoprotein C-II; Apolipoprotein C-III; apolipoprotein posttranslational proteoforms; Apolipoproteins; Atherosclerosis; cholesterol; Female; HDL; Humans; lipid metabolism; lipid transport; mass spectrometry; proteomics; race/ethnicity; Triglycerides; atherosclerosis; AA; MESA; proteomics; lipid metabolism; lipid transport; DPP-4; LPL; triglycerides; race/ethnicity; TRL; HDL; GFR; cholesterol; mass spectrometry; apolipoprotein posttranslational proteoforms; apoC-I; apoC-II; CA

Apolipoproteins (apo) C-I and C-II are key regulators of triglyceride and HDL metabolism. Both exist as full-size native and truncated (apoC-I'; apoC-II') posttranslational proteoforms. However, the determinants and the role of these proteoforms in lipid metabolism are unknown. Here, we me...