Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections

• Published in: Nature communications Vol. 14; no. 1; pp. 7510 - 12
• Main Authors: Cheng, Jian, Gan, Guihai, Zheng, Shaoqiu, Zhang, Guoying, Zhu, Chen, Liu, Shiyong, Hu, Jinming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 14/34; 14/63; 140/131; 140/58; 147/135; 147/28; 38/91; 639/301/54/990; 639/301/923/1028; 639/638/298/923/1028; Antibiotics; Biofilms; Catalysis; Ciprofloxacin; Drug resistance; Fabrication; Heterogeneity; Humanities and Social Sciences; Infections; Microenvironments; multidisciplinary; Nanoparticles; Nitric oxide; pH effects; Photoredox catalysis; Science; Science (multidisciplinary)

The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Her...