Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections
The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Her...
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| Published in | Nature communications Vol. 14; no. 1; pp. 7510 - 12 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
18.11.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant
Pseudomonas aeruginosa
(CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections.
Biofilms are heterogeneous and difficult to treat. Here, the authors report the preparation of micellar nanoparticles specifically for the treatment of biofilm, that release nitric oxide through two distinct photoredox catalysis mechanisms. |
|---|---|
| AbstractList | Abstract The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections. The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections. Biofilms are heterogeneous and difficult to treat. Here, the authors report the preparation of micellar nanoparticles specifically for the treatment of biofilm, that release nitric oxide through two distinct photoredox catalysis mechanisms. The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections.Biofilms are heterogeneous and difficult to treat. Here, the authors report the preparation of micellar nanoparticles specifically for the treatment of biofilm, that release nitric oxide through two distinct photoredox catalysis mechanisms. The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections.The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections. The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections. |
| ArticleNumber | 7510 |
| Author | Gan, Guihai Zhu, Chen Hu, Jinming Cheng, Jian Liu, Shiyong Zhang, Guoying Zheng, Shaoqiu |
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| Cites_doi | 10.1038/s41467-022-31479-x 10.1039/C8TB00299A 10.1128/AEM.01434-14 10.1038/s41557-019-0328-4 10.1089/wound.2014.0557 10.1002/anie.202219153 10.1038/s41551-022-00950-x 10.1002/anie.202202559 10.1039/D2SC03952D 10.1039/C2CC37181B 10.1002/advs.202000398 10.1021/ja5020053 10.1021/cr300503r 10.1021/bm500422v 10.1038/s41579-022-00692-2 10.1016/j.jconrel.2011.08.019 10.1128/MMBR.00043-12 10.1021/acsbiomaterials.9b01384 10.1038/s41579-020-0385-0 10.1021/acs.joc.6b01449 10.1021/acsnano.0c00269 10.1038/s41467-020-19651-7 10.1038/nature11313 10.1038/nrmicro.2016.94 10.1111/j.1524-475X.2008.00436.x 10.1038/ncomms13214 10.1021/jacs.1c07372 10.1038/nrmicro.2017.99 10.1021/acsinfecdis.0c00337 10.1016/j.copbio.2010.10.016 10.1016/j.freeradbiomed.2018.04.563 10.1038/s41467-021-26221-y 10.1021/acsnano.2c06328 10.1002/anie.201711044 10.1021/acs.macromol.9b01493 10.1039/C5SC01349F 10.1002/adhm.201800155 10.1128/microbiolspec.MB-0003-2014 10.1021/jacs.8b05514 10.1021/acsnano.6b01370 10.1111/j.1600-0625.2009.00931.x 10.1002/anie.202204526 10.1021/jacs.2c03444 10.1371/journal.ppat.1002493 10.1016/j.addr.2021.113916 10.1038/nmat3819 10.1021/jacs.9b09034 10.1038/nrmicro1838 10.1039/C6CS00185H 10.1038/s41467-020-20640-z 10.1021/jacs.8b06961 10.1128/JB.00975-09 10.1021/jacs.1c10659 10.1021/j100534a016 10.1021/acs.chemrev.6b00057 10.1002/anie.202107155 10.1039/c3cc49555h 10.1021/acs.molpharmaceut.2c00165 10.1021/jacs.2c01384 |
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| Copyright | The Author(s) 2023 The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023. The Author(s). |
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| References | Hu (CR14) 2020; 7 Zhou (CR33) 2018; 140 Wang (CR45) 2020; 11 Monroe (CR40) 1977; 81 Qian (CR21) 2022; 144 Han (CR32) 2022; 61 Xie (CR22) 2021; 12 Shen (CR8) 2021; 60 Ieda, Hotta, Miyata, Kimura, Nakagawa (CR34) 2014; 136 Shen (CR7) 2023; 62 Percival, McCarty, Lipsky (CR58) 2015; 4 Wu (CR38) 2022; 13 Liu (CR20) 2016; 10 Thorning, Henke, Ogilby (CR42) 2022; 144 Wu, Jung, Ma, Liu, Boyer (CR41) 2021; 12 Flemming (CR16) 2016; 14 Barraud (CR52) 2009; 191 Rouillard (CR25) 2021; 7 Jo, Price-Whelan, Dietrich (CR12) 2022; 20 Gao (CR50) 2020; 14 Chen (CR9) 2022; 61 Hall (CR26) 2020; 6 Sadrearhami (CR29) 2018; 6 Kanno, Toriyabe, Zhang, Imai, Tachi (CR57) 2010; 19 Xiu (CR59) 2022; 13 Lv (CR35) 2019; 141 Thorn, Howell, Wozniak, Prestidge, Thomas (CR24) 2021; 179 Gormley (CR37) 2018; 57 Gupta (CR18) 2018; 140 Ghosh (CR19) 2022; 6 Cui, Qiao, Xiong (CR46) 2022; 19 Beltran (CR47) 2014; 50 Buksh (CR4) 2022; 144 Shaw, Twilton, MacMillan (CR10) 2016; 81 Hobley (CR51) 2012; 8 Ha, O’Toole (CR54) 2015; 3 Chen, Schaap (CR53) 2012; 488 Li (CR6) 2022; 144 Prier, Rankic, MacMillan (CR2) 2013; 113 Nomeir, Fabre, Ferji (CR39) 2019; 52 Pei, Lamas-Samanamud (CR23) 2014; 80 Ding (CR43) 2011; 156 Wang (CR49) 2014; 13 Romero, Nicewicz (CR1) 2016; 116 Huang (CR5) 2019; 11 Duong (CR27) 2014; 15 Duong (CR30) 2013; 49 Reynal (CR48) 2015; 6 Koo, Allan, Howlin, Stoodley, Hall-Stoodley (CR17) 2017; 15 Sen (CR56) 2009; 17 Abee, Kovacs, Kuipers, van der Veen (CR13) 2011; 22 Li (CR44) 2016; 7 Corrigan, Shanmugam, Xu, Boyer (CR3) 2016; 45 Rumbaugh, Sauer (CR15) 2020; 18 Stewart, Franklin (CR11) 2008; 6 Römling, Galperin, Gomelsky (CR55) 2013; 77 He (CR31) 2018; 123 Yang, Feura, Ahonen, Schoenfisch (CR28) 2018; 7 Tao (CR36) 2022; 16 KP Rumbaugh (43415_CR15) 2020; 18 J Xie (43415_CR22) 2021; 12 ZQ Shen (43415_CR7) 2023; 62 HC Flemming (43415_CR16) 2016; 14 Z Wu (43415_CR38) 2022; 13 A Reynal (43415_CR48) 2015; 6 N Corrigan (43415_CR3) 2016; 45 HT Duong (43415_CR27) 2014; 15 ZQ Shen (43415_CR8) 2021; 60 H He (43415_CR31) 2018; 123 HT Duong (43415_CR30) 2013; 49 N Barraud (43415_CR52) 2009; 191 CR Thorn (43415_CR24) 2021; 179 A Beltran (43415_CR47) 2014; 50 Z Sadrearhami (43415_CR29) 2018; 6 J Jo (43415_CR12) 2022; 20 L Hobley (43415_CR51) 2012; 8 R Pei (43415_CR23) 2014; 80 ZH Chen (43415_CR9) 2022; 61 X Han (43415_CR32) 2022; 61 ML Li (43415_CR6) 2022; 144 Y Wang (43415_CR49) 2014; 13 S Tao (43415_CR36) 2022; 16 F Thorning (43415_CR42) 2022; 144 Y Liu (43415_CR20) 2016; 10 HY Huang (43415_CR5) 2019; 11 T Abee (43415_CR13) 2011; 22 E Kanno (43415_CR57) 2010; 19 Y Qian (43415_CR21) 2022; 144 Y Gao (43415_CR50) 2020; 14 KR Rouillard (43415_CR25) 2021; 7 N Ieda (43415_CR34) 2014; 136 B Nomeir (43415_CR39) 2019; 52 EY Zhou (43415_CR33) 2018; 140 H Koo (43415_CR17) 2017; 15 CK Prier (43415_CR2) 2013; 113 X Wang (43415_CR45) 2020; 11 MH Shaw (43415_CR10) 2016; 81 Y Li (43415_CR44) 2016; 7 JR Hall (43415_CR26) 2020; 6 BM Monroe (43415_CR40) 1977; 81 A Gupta (43415_CR18) 2018; 140 H Ding (43415_CR43) 2011; 156 D Hu (43415_CR14) 2020; 7 W Lv (43415_CR35) 2019; 141 S Cui (43415_CR46) 2022; 19 U Römling (43415_CR55) 2013; 77 CK Sen (43415_CR56) 2009; 17 C Wu (43415_CR41) 2021; 12 ZH Chen (43415_CR53) 2012; 488 NA Romero (43415_CR1) 2016; 116 DG Ha (43415_CR54) 2015; 3 PS Stewart (43415_CR11) 2008; 6 L Yang (43415_CR28) 2018; 7 SL Percival (43415_CR58) 2015; 4 S Ghosh (43415_CR19) 2022; 6 AJ Gormley (43415_CR37) 2018; 57 W Xiu (43415_CR59) 2022; 13 BF Buksh (43415_CR4) 2022; 144 |
| References_xml | – volume: 13 year: 2022 ident: CR59 article-title: Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections publication-title: Nat. Commun. doi: 10.1038/s41467-022-31479-x – volume: 6 start-page: 2945 year: 2018 end-page: 2959 ident: CR29 article-title: Recent advances in nitric oxide delivery for antimicrobial applications using polymer-based systems publication-title: J. Mater. Chem. B doi: 10.1039/C8TB00299A – volume: 80 start-page: 5340 year: 2014 end-page: 5348 ident: CR23 article-title: Inhibition of biofilm formation by T7 bacteriophages producing quorum-quenching enzymes publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.01434-14 – volume: 11 start-page: 1041 year: 2019 end-page: 1048 ident: CR5 article-title: Targeted photoredox catalysis in cancer cells publication-title: Nat. Chem. doi: 10.1038/s41557-019-0328-4 – volume: 4 start-page: 373 year: 2015 end-page: 381 ident: CR58 article-title: Biofilms and wounds: an overview of the evidence publication-title: Adv. Wound Care doi: 10.1089/wound.2014.0557 – volume: 62 start-page: e202219153 year: 2023 ident: CR7 article-title: Overcoming the oxygen dilemma in photoredox catalysis: near-infrared (NIR) light-triggered peroxynitrite generation for antibacterial applications publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202219153 – volume: 6 start-page: 1180 year: 2022 end-page: 1195 ident: CR19 article-title: A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-022-00950-x – volume: 61 start-page: e202202559 year: 2022 ident: CR32 article-title: Spatiotemporal release of reactive oxygen species and no for overcoming biofilm heterogeneity publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202202559 – volume: 13 start-page: 11519 year: 2022 end-page: 11532 ident: CR38 article-title: An aqueous photo-controlled polymerization under NIR wavelengths: synthesis of polymeric nanoparticles through thick barriers publication-title: Chem. Sci. doi: 10.1039/D2SC03952D – volume: 49 start-page: 4190 year: 2013 end-page: 4192 ident: CR30 article-title: Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers publication-title: Chem. Commun. doi: 10.1039/C2CC37181B – volume: 7 start-page: 2000398 year: 2020 ident: CR14 article-title: Relief of biofilm hypoxia using an oxygen nanocarrier: a new paradigm for enhanced antibiotic therapy publication-title: Adv. Sci. doi: 10.1002/advs.202000398 – volume: 136 start-page: 7085 year: 2014 end-page: 7091 ident: CR34 article-title: Photomanipulation of vasodilation with a blue-light-controllable nitric oxide releaser publication-title: J. Am. Chem. Soc. doi: 10.1021/ja5020053 – volume: 113 start-page: 5322 year: 2013 end-page: 5363 ident: CR2 article-title: Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis publication-title: Chem. Rev. doi: 10.1021/cr300503r – volume: 15 start-page: 2583 year: 2014 end-page: 2589 ident: CR27 article-title: Nanoparticle (star polymer) delivery of nitric oxide effectively negates Pseudomonas aeruginosa biofilm formation publication-title: Biomacromolecules doi: 10.1021/bm500422v – volume: 20 start-page: 593 year: 2022 end-page: 607 ident: CR12 article-title: Gradients and consequences of heterogeneity in biofilms publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-022-00692-2 – volume: 156 start-page: 276 year: 2011 end-page: 280 ident: CR43 article-title: Photoactivation switch from Type II to Type I reactions by electron-rich micelles for improved photodynamic therapy of cancer cells under hypoxia publication-title: J. Control. Release doi: 10.1016/j.jconrel.2011.08.019 – volume: 77 start-page: 1 year: 2013 end-page: 52 ident: CR55 article-title: Cyclic di-GMP: the first 25 years of a universal bacterial second messenger publication-title: Microbiol. Mol. Biol. Rev. doi: 10.1128/MMBR.00043-12 – volume: 6 start-page: 433 year: 2020 end-page: 441 ident: CR26 article-title: Mode of nitric oxide delivery affects antibacterial action publication-title: ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.9b01384 – volume: 18 start-page: 571 year: 2020 end-page: 586 ident: CR15 article-title: Biofilm dispersion publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-020-0385-0 – volume: 81 start-page: 6898 year: 2016 end-page: 6926 ident: CR10 article-title: Photoredox catalysis in organic chemistry publication-title: J. Org. Chem. doi: 10.1021/acs.joc.6b01449 – volume: 14 start-page: 5686 year: 2020 end-page: 5699 ident: CR50 article-title: Size and charge adaptive clustered nanoparticles targeting the biofilm microenvironment for chronic lung infection management publication-title: ACS Nano doi: 10.1021/acsnano.0c00269 – volume: 11 year: 2020 ident: CR45 article-title: Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window publication-title: Nat. Commun. doi: 10.1038/s41467-020-19651-7 – volume: 488 start-page: 680 year: 2012 end-page: 683 ident: CR53 article-title: The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium publication-title: Nature doi: 10.1038/nature11313 – volume: 14 start-page: 563 year: 2016 end-page: 575 ident: CR16 article-title: Biofilms: an emergent form of bacterial life publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2016.94 – volume: 17 start-page: 1 year: 2009 end-page: 18 ident: CR56 article-title: Wound healing essentials: let there be oxygen publication-title: Wound Repair Regen doi: 10.1111/j.1524-475X.2008.00436.x – volume: 7 year: 2016 ident: CR44 article-title: Molecular basis of cooperativity in pH-triggered supramolecular self-assembly publication-title: Nat. Commun. doi: 10.1038/ncomms13214 – volume: 144 start-page: 163 year: 2022 end-page: 173 ident: CR6 article-title: Conditionally activatable photoredox catalysis in living systems publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.1c07372 – volume: 15 start-page: 740 year: 2017 end-page: 755 ident: CR17 article-title: Targeting microbial biofilms: current and prospective therapeutic strategies publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2017.99 – volume: 7 start-page: 23 year: 2021 end-page: 33 ident: CR25 article-title: Exogenous nitric oxide improves antibiotic susceptibility in resistant bacteria publication-title: ACS Infect. Dis. doi: 10.1021/acsinfecdis.0c00337 – volume: 22 start-page: 172 year: 2011 end-page: 179 ident: CR13 article-title: Biofilm formation and dispersal in Gram-positive bacteria publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2010.10.016 – volume: 123 start-page: 1 year: 2018 end-page: 7 ident: CR31 article-title: A Photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications publication-title: Free Radical Biol. Med. doi: 10.1016/j.freeradbiomed.2018.04.563 – volume: 12 year: 2021 ident: CR22 article-title: Addressing MRSA infection and antibacterial resistance with peptoid polymers publication-title: Nat. Commun. doi: 10.1038/s41467-021-26221-y – volume: 16 start-page: 20376 year: 2022 end-page: 20388 ident: CR36 article-title: Red light-mediated photoredox catalysis triggers nitric oxide release for treatment of cutibacterium acne induced intervertebral disc degeneration publication-title: ACS Nano doi: 10.1021/acsnano.2c06328 – volume: 57 start-page: 1557 year: 2018 end-page: 1562 ident: CR37 article-title: An oxygen-tolerant PET-RAFT polymerization for screening structure-activity relationships publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201711044 – volume: 52 start-page: 6898 year: 2019 end-page: 6903 ident: CR39 article-title: Effect of tertiary amines on the photoinduced electron transfer reversible addition fragmentation chain transfer (PET-RAFT) polymerization publication-title: Macromolecules doi: 10.1021/acs.macromol.9b01493 – volume: 6 start-page: 4855 year: 2015 end-page: 4859 ident: CR48 article-title: Unravelling the pH-dependence of a molecular photocatalytic system for hydrogen production publication-title: Chem. Sci. doi: 10.1039/C5SC01349F – volume: 7 start-page: e1800155 year: 2018 ident: CR28 article-title: Nitric oxide-releasing macromolecular scaffolds for antibacterial applications publication-title: Adv. Health Mater. doi: 10.1002/adhm.201800155 – volume: 3 start-page: 1 year: 2015 end-page: 12 ident: CR54 article-title: c-di-GMP and its effects on biofilm formation and dispersion: a Review publication-title: Microbiol. Spectr. doi: 10.1128/microbiolspec.MB-0003-2014 – volume: 140 start-page: 11686 year: 2018 end-page: 11697 ident: CR33 article-title: Near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b05514 – volume: 10 start-page: 4779 year: 2016 end-page: 4789 ident: CR20 article-title: Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms publication-title: ACS Nano doi: 10.1021/acsnano.6b01370 – volume: 19 start-page: 154 year: 2010 end-page: 156 ident: CR57 article-title: Biofilm formation on rat skin wounds by Pseudomonas aeruginosa carrying the green fluorescent protein gene publication-title: Exp. Dermatol. doi: 10.1111/j.1600-0625.2009.00931.x – volume: 61 start-page: e202204526 year: 2022 ident: CR9 article-title: Oxygen-tolerant photoredox catalysis triggers nitric oxide release for antibacterial applications publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202204526 – volume: 144 start-page: 10902 year: 2022 end-page: 10911 ident: CR42 article-title: Perturbed and activated decay: the lifetime of singlet oxygen in liquid organic solvents publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.2c03444 – volume: 8 start-page: e1002493 year: 2012 ident: CR51 article-title: Discrete cyclic di-GMP-dependent control of bacterial predation versus axenic growth in Bdellovibrio bacteriovorus publication-title: PLOS Pathog doi: 10.1371/journal.ppat.1002493 – volume: 179 start-page: 113916 year: 2021 ident: CR24 article-title: Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems publication-title: Adv. Drug Delivery Rev doi: 10.1016/j.addr.2021.113916 – volume: 13 start-page: 204 year: 2014 end-page: 212 ident: CR49 article-title: A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals publication-title: Nat. Mater. doi: 10.1038/nmat3819 – volume: 141 start-page: 17482 year: 2019 end-page: 17486 ident: CR35 article-title: Upconversion-like photolysis of BODIPY-based prodrugs via a one-photon process publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b09034 – volume: 6 start-page: 199 year: 2008 end-page: 210 ident: CR11 article-title: Physiological heterogeneity in biofilms publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro1838 – volume: 45 start-page: 6165 year: 2016 end-page: 6212 ident: CR3 article-title: Photocatalysis in organic and polymer synthesis publication-title: Chem. Soc. Rev. doi: 10.1039/C6CS00185H – volume: 12 year: 2021 ident: CR41 article-title: Unravelling an oxygen-mediated reductive quenching pathway for photopolymerisation under long wavelengths publication-title: Nat. Commun. doi: 10.1038/s41467-020-20640-z – volume: 140 start-page: 12137 year: 2018 end-page: 12143 ident: CR18 article-title: Engineered polymer nanoparticles with unprecedented antimicrobial efficacy and therapeutic indices against multidrug-resistant bacteria and biofilms publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b06961 – volume: 191 start-page: 7333 year: 2009 end-page: 7342 ident: CR52 article-title: Nitric oxide signaling in biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal publication-title: J. Bacteriol. doi: 10.1128/JB.00975-09 – volume: 144 start-page: 1690 year: 2022 end-page: 1699 ident: CR21 article-title: Secondary amine pendant beta-peptide polymers displaying potent antibacterial activity and promising therapeutic potential in treating MRSA-induced wound infections and keratitis publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.1c10659 – volume: 81 start-page: 1861 year: 1977 end-page: 1864 ident: CR40 article-title: Quenching of singlet oxygen by aliphatic-amines publication-title: J. Phys. Chem. doi: 10.1021/j100534a016 – volume: 116 start-page: 10075 year: 2016 end-page: 10166 ident: CR1 article-title: Organic photoredox catalysis publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.6b00057 – volume: 60 start-page: 20452 year: 2021 end-page: 20460 ident: CR8 article-title: Red-light-mediated photoredox catalysis enables self-reporting nitric oxide release for efficient antibacterial treatment publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202107155 – volume: 50 start-page: 3579 year: 2014 end-page: 3581 ident: CR47 article-title: Turn-on fluorescent probes for nitric oxide sensing based on the ortho-hydroxyamino structure showing no interference with dehydroascorbic acid publication-title: Chem. Commun. doi: 10.1039/c3cc49555h – volume: 19 start-page: 2406 year: 2022 end-page: 2417 ident: CR46 article-title: Antibacterial and biofilm-eradicating activities of pH-Responsive vesicles against pseudomonas aeruginosa publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.2c00165 – volume: 144 start-page: 6154 year: 2022 end-page: 6162 ident: CR4 article-title: μMap-Red: proximity labeling by red light photocatalysis publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.2c01384 – volume: 19 start-page: 154 year: 2010 ident: 43415_CR57 publication-title: Exp. Dermatol. doi: 10.1111/j.1600-0625.2009.00931.x – volume: 11 year: 2020 ident: 43415_CR45 publication-title: Nat. Commun. doi: 10.1038/s41467-020-19651-7 – volume: 81 start-page: 6898 year: 2016 ident: 43415_CR10 publication-title: J. Org. Chem. doi: 10.1021/acs.joc.6b01449 – volume: 13 year: 2022 ident: 43415_CR59 publication-title: Nat. Commun. doi: 10.1038/s41467-022-31479-x – volume: 136 start-page: 7085 year: 2014 ident: 43415_CR34 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja5020053 – volume: 7 year: 2016 ident: 43415_CR44 publication-title: Nat. Commun. doi: 10.1038/ncomms13214 – volume: 15 start-page: 740 year: 2017 ident: 43415_CR17 publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2017.99 – volume: 4 start-page: 373 year: 2015 ident: 43415_CR58 publication-title: Adv. Wound Care doi: 10.1089/wound.2014.0557 – volume: 6 start-page: 2945 year: 2018 ident: 43415_CR29 publication-title: J. Mater. Chem. B doi: 10.1039/C8TB00299A – volume: 50 start-page: 3579 year: 2014 ident: 43415_CR47 publication-title: Chem. Commun. doi: 10.1039/c3cc49555h – volume: 60 start-page: 20452 year: 2021 ident: 43415_CR8 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202107155 – volume: 116 start-page: 10075 year: 2016 ident: 43415_CR1 publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.6b00057 – volume: 13 start-page: 11519 year: 2022 ident: 43415_CR38 publication-title: Chem. Sci. doi: 10.1039/D2SC03952D – volume: 144 start-page: 10902 year: 2022 ident: 43415_CR42 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.2c03444 – volume: 140 start-page: 12137 year: 2018 ident: 43415_CR18 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b06961 – volume: 12 year: 2021 ident: 43415_CR41 publication-title: Nat. Commun. doi: 10.1038/s41467-020-20640-z – volume: 20 start-page: 593 year: 2022 ident: 43415_CR12 publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-022-00692-2 – volume: 77 start-page: 1 year: 2013 ident: 43415_CR55 publication-title: Microbiol. Mol. Biol. Rev. doi: 10.1128/MMBR.00043-12 – volume: 18 start-page: 571 year: 2020 ident: 43415_CR15 publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-020-0385-0 – volume: 81 start-page: 1861 year: 1977 ident: 43415_CR40 publication-title: J. Phys. Chem. doi: 10.1021/j100534a016 – volume: 49 start-page: 4190 year: 2013 ident: 43415_CR30 publication-title: Chem. Commun. doi: 10.1039/C2CC37181B – volume: 6 start-page: 4855 year: 2015 ident: 43415_CR48 publication-title: Chem. Sci. doi: 10.1039/C5SC01349F – volume: 191 start-page: 7333 year: 2009 ident: 43415_CR52 publication-title: J. Bacteriol. doi: 10.1128/JB.00975-09 – volume: 10 start-page: 4779 year: 2016 ident: 43415_CR20 publication-title: ACS Nano doi: 10.1021/acsnano.6b01370 – volume: 144 start-page: 1690 year: 2022 ident: 43415_CR21 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.1c10659 – volume: 61 start-page: e202202559 year: 2022 ident: 43415_CR32 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202202559 – volume: 6 start-page: 199 year: 2008 ident: 43415_CR11 publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro1838 – volume: 13 start-page: 204 year: 2014 ident: 43415_CR49 publication-title: Nat. Mater. doi: 10.1038/nmat3819 – volume: 14 start-page: 563 year: 2016 ident: 43415_CR16 publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2016.94 – volume: 179 start-page: 113916 year: 2021 ident: 43415_CR24 publication-title: Adv. Drug Delivery Rev doi: 10.1016/j.addr.2021.113916 – volume: 141 start-page: 17482 year: 2019 ident: 43415_CR35 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b09034 – volume: 19 start-page: 2406 year: 2022 ident: 43415_CR46 publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.2c00165 – volume: 123 start-page: 1 year: 2018 ident: 43415_CR31 publication-title: Free Radical Biol. Med. doi: 10.1016/j.freeradbiomed.2018.04.563 – volume: 6 start-page: 1180 year: 2022 ident: 43415_CR19 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-022-00950-x – volume: 15 start-page: 2583 year: 2014 ident: 43415_CR27 publication-title: Biomacromolecules doi: 10.1021/bm500422v – volume: 156 start-page: 276 year: 2011 ident: 43415_CR43 publication-title: J. Control. Release doi: 10.1016/j.jconrel.2011.08.019 – volume: 144 start-page: 163 year: 2022 ident: 43415_CR6 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.1c07372 – volume: 22 start-page: 172 year: 2011 ident: 43415_CR13 publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2010.10.016 – volume: 52 start-page: 6898 year: 2019 ident: 43415_CR39 publication-title: Macromolecules doi: 10.1021/acs.macromol.9b01493 – volume: 62 start-page: e202219153 year: 2023 ident: 43415_CR7 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202219153 – volume: 6 start-page: 433 year: 2020 ident: 43415_CR26 publication-title: ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.9b01384 – volume: 61 start-page: e202204526 year: 2022 ident: 43415_CR9 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202204526 – volume: 57 start-page: 1557 year: 2018 ident: 43415_CR37 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201711044 – volume: 80 start-page: 5340 year: 2014 ident: 43415_CR23 publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.01434-14 – volume: 16 start-page: 20376 year: 2022 ident: 43415_CR36 publication-title: ACS Nano doi: 10.1021/acsnano.2c06328 – volume: 7 start-page: e1800155 year: 2018 ident: 43415_CR28 publication-title: Adv. Health Mater. doi: 10.1002/adhm.201800155 – volume: 113 start-page: 5322 year: 2013 ident: 43415_CR2 publication-title: Chem. Rev. doi: 10.1021/cr300503r – volume: 17 start-page: 1 year: 2009 ident: 43415_CR56 publication-title: Wound Repair Regen doi: 10.1111/j.1524-475X.2008.00436.x – volume: 144 start-page: 6154 year: 2022 ident: 43415_CR4 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.2c01384 – volume: 14 start-page: 5686 year: 2020 ident: 43415_CR50 publication-title: ACS Nano doi: 10.1021/acsnano.0c00269 – volume: 8 start-page: e1002493 year: 2012 ident: 43415_CR51 publication-title: PLOS Pathog doi: 10.1371/journal.ppat.1002493 – volume: 488 start-page: 680 year: 2012 ident: 43415_CR53 publication-title: Nature doi: 10.1038/nature11313 – volume: 12 year: 2021 ident: 43415_CR22 publication-title: Nat. Commun. doi: 10.1038/s41467-021-26221-y – volume: 140 start-page: 11686 year: 2018 ident: 43415_CR33 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b05514 – volume: 11 start-page: 1041 year: 2019 ident: 43415_CR5 publication-title: Nat. Chem. doi: 10.1038/s41557-019-0328-4 – volume: 7 start-page: 2000398 year: 2020 ident: 43415_CR14 publication-title: Adv. Sci. doi: 10.1002/advs.202000398 – volume: 45 start-page: 6165 year: 2016 ident: 43415_CR3 publication-title: Chem. Soc. Rev. doi: 10.1039/C6CS00185H – volume: 3 start-page: 1 year: 2015 ident: 43415_CR54 publication-title: Microbiol. Spectr. doi: 10.1128/microbiolspec.MB-0003-2014 – volume: 7 start-page: 23 year: 2021 ident: 43415_CR25 publication-title: ACS Infect. Dis. doi: 10.1021/acsinfecdis.0c00337 |
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| Snippet | The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders... Abstract The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen... |
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| SubjectTerms | 14/34 14/63 140/131 140/58 147/135 147/28 38/91 639/301/54/990 639/301/923/1028 639/638/298/923/1028 Antibiotics Biofilms Catalysis Ciprofloxacin Drug resistance Fabrication Heterogeneity Humanities and Social Sciences Infections Microenvironments multidisciplinary Nanoparticles Nitric oxide pH effects Photoredox catalysis Science Science (multidisciplinary) |
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| Title | Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections |
| URI | https://link.springer.com/article/10.1038/s41467-023-43415-8 https://www.proquest.com/docview/2891383530 https://www.proquest.com/docview/2891753067 https://doaj.org/article/9e10beb896cb453a8f465a8d6661f30d |
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