Recent Advances in Placenta-Heart Interactions

• Published in: Frontiers in physiology Vol. 9; p. 735
• Main Author: Maslen, Cheryl L
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.06.2018
• Subjects: congenital heart defects; fetal environment; genetic risk factors; heart–placental axis; Physiology; placental insufficiency; heart–placental axis; genetic risk factors; placental insufficiency; fetal environment; congenital heart defects

Congenital heart defects (CHD) occur in ∼1 in every 100 live births. In addition, an estimated 10% of fetal loss is due to severe forms of CHD. This makes heart defects the most frequently occurring birth defect and single cause of in utero fatality in humans. There is considerable evidence that CHD...