The Use of Probiotic Therapy in Metabolic and Neurological Diseases

The human gut is home to trillions of microbes that interact with host cells to influence and contribute to body functions. The number of scientific studies focusing on the gut microbiome has exponentially increased in recent years. Studies investigating factors that may potentially affect the gut m...

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Published inFrontiers in nutrition (Lausanne) Vol. 9; p. 887019
Main Authors Lee, Shirley H F, Ahmad, Siti R, Lim, Ya C, Zulkipli, Ihsan N
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 03.05.2022
Subjects
diabetes
microbes
neurodegenerative diseases
Nutrition
obesity
probiotics
therapy
neurodegenerative diseases
microbes
diabetes
therapy
obesity
probiotics
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Abstract The human gut is home to trillions of microbes that interact with host cells to influence and contribute to body functions. The number of scientific studies focusing on the gut microbiome has exponentially increased in recent years. Studies investigating factors that may potentially affect the gut microbiome and may be used for therapeutic purposes in diseases where dysbioses in the gut microbiome have been shown are of particular interest. This review compiles current evidence available in the scientific literature on the use of probiotics to treat metabolic diseases and autism spectrum disorders (ASDs) to analyze the efficacy of probiotics in these diseases. To do this, we must first define the healthy gut microbiome before looking at the interplay between the gut microbiome and diseases, and how probiotics affect this interaction. In metabolic diseases, such as obesity and diabetes, probiotic supplementation positively impacts pathological parameters. Conversely, the gut-brain axis significantly impacts neurodevelopmental disorders such as ASDs. However, manipulating the gut microbiome and disease symptoms using probiotics has less pronounced effects on neurodevelopmental diseases. This may be due to a more complex interplay between genetics and the environment in these diseases. In conclusion, the use of microbe-based probiotic therapy may potentially have beneficial effects in ameliorating the pathology of various diseases. Validation of available data for the development of personalized treatment regimens for affected patients is still required.
AbstractList The human gut is home to trillions of microbes that interact with host cells to influence and contribute to body functions. The number of scientific studies focusing on the gut microbiome has exponentially increased in recent years. Studies investigating factors that may potentially affect the gut microbiome and may be used for therapeutic purposes in diseases where dysbioses in the gut microbiome have been shown are of particular interest. This review compiles current evidence available in the scientific literature on the use of probiotics to treat metabolic diseases and autism spectrum disorders (ASDs) to analyze the efficacy of probiotics in these diseases. To do this, we must first define the healthy gut microbiome before looking at the interplay between the gut microbiome and diseases, and how probiotics affect this interaction. In metabolic diseases, such as obesity and diabetes, probiotic supplementation positively impacts pathological parameters. Conversely, the gut–brain axis significantly impacts neurodevelopmental disorders such as ASDs. However, manipulating the gut microbiome and disease symptoms using probiotics has less pronounced effects on neurodevelopmental diseases. This may be due to a more complex interplay between genetics and the environment in these diseases. In conclusion, the use of microbe-based probiotic therapy may potentially have beneficial effects in ameliorating the pathology of various diseases. Validation of available data for the development of personalized treatment regimens for affected patients is still required.
Author Ahmad, Siti R
Lim, Ya C
Zulkipli, Ihsan N
Lee, Shirley H F
AuthorAffiliation Pengiran Anak Puteri Rashidah Sa’adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam , Gadong , Brunei
AuthorAffiliation_xml – name: Pengiran Anak Puteri Rashidah Sa’adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam , Gadong , Brunei
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  givenname: Shirley H F
  surname: Lee
  fullname: Lee, Shirley H F
  organization: Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei
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  givenname: Siti R
  surname: Ahmad
  fullname: Ahmad, Siti R
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  givenname: Ya C
  surname: Lim
  fullname: Lim, Ya C
  organization: Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei
– sequence: 4
  givenname: Ihsan N
  surname: Zulkipli
  fullname: Zulkipli, Ihsan N
  organization: Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei
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Keywords neurodegenerative diseases
microbes
diabetes
therapy
obesity
probiotics
Language English
License Copyright © 2022 Lee, Ahmad, Lim and Zulkipli.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Reviewed by: Anchalee Rawangkan, University of Phayao, Thailand; Eric Banan-Mwine Daliri, Kangwon National University, South Korea
This article was submitted to Nutritional Epidemiology, a section of the journal Frontiers in Nutrition
Edited by: Surasak Saokaew, University of Phayao, Thailand
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Snippet The human gut is home to trillions of microbes that interact with host cells to influence and contribute to body functions. The number of scientific studies...
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SubjectTerms diabetes
microbes
neurodegenerative diseases
Nutrition
obesity
probiotics
therapy
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Title The Use of Probiotic Therapy in Metabolic and Neurological Diseases
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