IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin

• Published in: Frontiers in immunology Vol. 9; p. 1211
• Main Authors: Prout, Melanie Sarah, Kyle, Ryan L, Ronchese, Franca, Le Gros, Graham
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.06.2018
• Subjects: IL-13; IL-4; Immunology; lung; lymph node; skin; Th2; lung; non-lymphoid tissues; lymph node; IL-4; skin; IL-13; Th2

Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4's role in CD4 Th2 responses by using transgenic mice that express a dual IL-4 AmCyan/IL-13 DsRed (IL-4AC/IL-13DR) fluorescent...