Gramicidin Channel Kinetics under Tension
We have measured the effect of tension on dimerization kinetics of the channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a micropipette electrode, we are able to simultaneously monitor membrane tension and electrical activity. We find that the dimer formation rate i...
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| Published in | Biophysical journal Vol. 74; no. 1; pp. 328 - 337 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
1998
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| Subjects | |
| Online Access | Get full text |
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| Abstract | We have measured the effect of tension on dimerization kinetics of the channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a micropipette electrode, we are able to simultaneously monitor membrane tension and electrical activity. We find that the dimer formation rate increases by a factor of 5 as tension ranges from 0 to 4
dyn/cm. The dimer lifetime also increases with tension. This behavior is well described by a phenomenological model of membrane elasticity in which tension modulates the mismatch in thickness between the gramicidin dimer and membrane. |
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| AbstractList | We have measured the effect of tension on dimerization kinetics of the channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a micropipette electrode, we are able to simultaneously monitor membrane tension and electrical activity. We find that the dimer formation rate increases by a factor of 5 as tension ranges from 0 to 4 dyn/cm. The dimer lifetime also increases with tension. This behavior is well described by a phenomenological model of membrane elasticity in which tension modulates the mismatch in thickness between the gramicidin dimer and membrane. We have measured the effect of tension on dimerization kinetics of the channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a micropipette electrode, we are able to simultaneously monitor membrane tension and electrical activity. We find that the dimer formation rate increases by a factor of 5 as tension ranges from 0 to 4 dyn/cm. The dimer lifetime also increases with tension. This behavior is well described by a phenomenological model of membrane elasticity in which tension modulates the mismatch in thickness between the gramicidin dimer and membrane. |
| Author | Mesquita, O.N. Andersen, O.S. Nielsen, C. Libchaber, A. Fygenson, D.K. Goulian, M. |
| AuthorAffiliation | Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021, USA. goulian@menard.rockefeller.edu |
| AuthorAffiliation_xml | – name: Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021, USA. goulian@menard.rockefeller.edu |
| Author_xml | – sequence: 1 givenname: M. surname: Goulian fullname: Goulian, M. email: goulian@menard.rockefeller.edu organization: Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021 – sequence: 2 givenname: O.N. surname: Mesquita fullname: Mesquita, O.N. organization: Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021 – sequence: 3 givenname: D.K. surname: Fygenson fullname: Fygenson, D.K. organization: Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021 – sequence: 4 givenname: C. surname: Nielsen fullname: Nielsen, C. organization: Department of Physiology and Biophysics, Cornell University Medical College, New York, New York 10021 USA – sequence: 5 givenname: O.S. surname: Andersen fullname: Andersen, O.S. organization: Department of Physiology and Biophysics, Cornell University Medical College, New York, New York 10021 USA – sequence: 6 givenname: A. surname: Libchaber fullname: Libchaber, A. organization: Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9449333$$D View this record in MEDLINE/PubMed |
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| Snippet | We have measured the effect of tension on dimerization kinetics of the channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a... |
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| SubjectTerms | Dimerization Electrochemistry Gramicidin - analogs & derivatives Gramicidin - chemistry Ion Channels - chemistry Ion Channels - physiology Lipid Bilayers Models, Biological Models, Molecular Patch-Clamp Techniques - instrumentation Phosphatidylcholines - chemistry Probability Stress, Mechanical Thermodynamics |
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| Title | Gramicidin Channel Kinetics under Tension |
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