Clinical Trials of Oncolytic Viruses in Breast Cancer
Breast cancer is the second most common kind of cancer worldwide and oncolytic viruses may offer a new treatment approach. There are three different types of oncolytic viruses used in clinical trials; (i) oncolytic viruses with natural anti-neoplastic properties; (ii) oncolytic viruses designed for...
Saved in:
Published in | Frontiers in oncology Vol. 11; p. 803050 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
23.12.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Breast cancer is the second most common kind of cancer worldwide and oncolytic viruses may offer a new treatment approach. There are three different types of oncolytic viruses used in clinical trials; (i) oncolytic viruses with natural anti-neoplastic properties; (ii) oncolytic viruses designed for tumor-selective replication; (iii) oncolytic viruses modified to activate the immune system. Currently, fourteen different oncolytic viruses have been investigated in eighteen published clinical trials. These trials demonstrate that oncolytic viruses are well tolerated and safe for use in patients and display clinical activity. However, these trials mainly studied a small number of patients with different advanced tumors including some with breast cancer. Future trials should focus on breast cancer and investigate optimal routes of administration, occurrence of neutralizing antibodies, viral gene expression, combinations with other antineoplastic therapies, and identify subtypes that are particularly suitable for oncolytic virotherapy. |
---|---|
AbstractList | Breast cancer is the second most common kind of cancer worldwide and oncolytic viruses may offer a new treatment approach. There are three different types of oncolytic viruses used in clinical trials; (i) oncolytic viruses with natural anti-neoplastic properties; (ii) oncolytic viruses designed for tumor-selective replication; (iii) oncolytic viruses modified to activate the immune system. Currently, fourteen different oncolytic viruses have been investigated in eighteen published clinical trials. These trials demonstrate that oncolytic viruses are well tolerated and safe for use in patients and display clinical activity. However, these trials mainly studied a small number of patients with different advanced tumors including some with breast cancer. Future trials should focus on breast cancer and investigate optimal routes of administration, occurrence of neutralizing antibodies, viral gene expression, combinations with other antineoplastic therapies, and identify subtypes that are particularly suitable for oncolytic virotherapy. |
Author | Hartkopf, Andreas D Carter, Mary E Lauer, Ulrich M Koch, André |
AuthorAffiliation | 1 Department of Obstetrics and Gynaecology, University of Tuebingen , Tuebingen , Germany 2 Department of Internal Medicine VIII, Medical Oncology & Pneumology, University of Tuebingen , Tuebingen , Germany |
AuthorAffiliation_xml | – name: 2 Department of Internal Medicine VIII, Medical Oncology & Pneumology, University of Tuebingen , Tuebingen , Germany – name: 1 Department of Obstetrics and Gynaecology, University of Tuebingen , Tuebingen , Germany |
Author_xml | – sequence: 1 givenname: Mary E surname: Carter fullname: Carter, Mary E organization: Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany – sequence: 2 givenname: André surname: Koch fullname: Koch, André organization: Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany – sequence: 3 givenname: Ulrich M surname: Lauer fullname: Lauer, Ulrich M organization: Department of Internal Medicine VIII, Medical Oncology & Pneumology, University of Tuebingen, Tuebingen, Germany – sequence: 4 givenname: Andreas D surname: Hartkopf fullname: Hartkopf, Andreas D organization: Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35004328$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkb1PHDEQxa2IKHyEPlW0Jc1dxp-7biLBKRAkJBoSpbO8Y5sY7dlg7yHx38fHEQTTeDR-7zcjvUOyl3LyhHyhsOR80N9CTrhkwOhyAA4SPpADxrhYaMH_7L3p98lxrXfQSkmgwD-RfS4BBGfDAZGrKaaIdupuSrRT7XLorhPm6WmO2P2OZVN97WLqzoq3de5WNqEvn8nH0MT--OU9Ir_Of9ysfi6uri8uV6dXCxSKzQtltXSWWyakF8yhdOi8VnwUI9VW6hHHYFmQDlBDGBQw19MwKh0osp45fkQud1yX7Z25L3Fty5PJNprnQS63xpZ26OQNNiNwL0aGIPogRoW20RxXrBdAbWN937HuN-PaO_RpLnZ6B33_k-Jfc5sfzdBzLrVugJMXQMkPG19ns44V_TTZ5POmGqboIKGtU00KOymWXGvx4XUNBbMNz2zDM9vwzC68Zvn69rxXw_-o-D-YVpfT |
CitedBy_id | crossref_primary_10_3390_cancers15082204 crossref_primary_10_3389_fimmu_2024_1375433 crossref_primary_10_1007_s12609_023_00492_4 crossref_primary_10_1186_s40164_022_00338_2 crossref_primary_10_3389_fcell_2023_1111796 crossref_primary_10_1007_s11912_022_01339_4 crossref_primary_10_3389_fonc_2023_1186888 crossref_primary_10_3389_fonc_2022_919072 crossref_primary_10_1142_S0218127423500621 crossref_primary_10_3390_md21020077 crossref_primary_10_1016_j_apsb_2024_03_007 crossref_primary_10_3390_v16040567 |
Cites_doi | 10.1158/1078-0432.CCR-06-0759 10.1007/s10549-021-06423-0 10.1016/j.ymthe.2004.06.158 10.1007/s11523-018-0608-8 10.1245/ASO.2006.08.035 10.1038/sj.gt.3301885 10.1158/1078-0432.CCR-05-2038 10.1038/mt.2009.262 10.2217/fmb.12.4 10.3322/caac.21654 10.1038/nbt.2287 10.18632/oncotarget.2901 10.2217/fon.10.66 10.1158/1538-7445.Sabcs19-gs3-04 10.1080/2162402X.2015.1078057 10.1038/sj.gt.3302555 10.3390/cancers10050144 10.1007/s10549-017-4538-4 10.2174/1566523218666180910163805 10.1001/jamaoncol.2016.2064 10.1038/sj.cgt.7701080 10.1158/1078-0432.CCR-12-2546 10.1016/j.tim.2008.07.009 10.1158/1078-0432.CCR-0349-03 10.1016/S0140-6736(16)31891-8 10.1038/nrc948 10.1172/JCI9762 10.1038/mt.2014.194 10.1200/JCO.2014.58.3377 10.1038/sj.cgt.7701110 10.1038/nrc3770 10.1158/1078-0432.CCR-09-3167 10.1016/S0952-7915(99)80064-8 10.2967/jnumed.121.262485 10.6004/jnccn.2020.7554 10.1007/978-3-642-59421-2_16 10.1158/0008-5472.CAN-09-3567 10.1038/nrd4663 10.1200/JCO.2002.08.042 10.1055/s-0031-1298281 10.3390/v13061128 10.1002/ijc.26216 10.1016/j.tips.2007.05.005 10.1016/j.virusres.2014.02.016 10.1016/S1470-2045(20)30754-3 10.1016/S0140-6736(20)32531-9 10.18632/oncotarget.5116 10.20506/rst.19.2.1231 10.1056/NEJMoa1413513 10.1016/j.cell.2017.01.017 10.1038/nrc3239 10.1016/j.micinf.2006.10.019 10.1016/j.ygyno.2013.05.004 10.1038/sj.onc.1203251 10.1136/jitc-2020-001486 10.1126/science.1851332 10.1016/j.cell.2017.08.027 10.1158/2326-6066.CIR-14-0015 10.2174/156800907780058808 10.1002/jcp.27150 10.1099/0022-1317-83-12-2915 10.1007/s10637-015-0216-8 10.1056/NEJMoa1809615 10.1038/gt.2009.103 10.1007/s10637-009-9279-8 10.1038/gt.2008.179 10.1016/j.annonc.2021.05.801 10.1006/viro.1993.1602 10.1016/j.biochi.2007.03.001 10.1038/s41417-020-00265-6 10.1093/hmg/10.7.677 10.1038/cgt.2011.80 10.1056/NEJMoa1910549 10.1016/j.ygyno.2011.06.021 10.3332/ecancer.2020.1149 10.1080/2162402X.2020.1729300 10.1056/NEJMoa1903765 10.1006/mthe.2001.0318 10.1016/j.ccr.2005.06.009 10.2147/OV.S54780 10.1038/77558 10.1007/s10637-012-9865-z 10.1001/jamaoncol.2017.4445 10.1016/S1470-2045(13)70130-X 10.1186/s40364-021-00318-4 10.1159/000453569 10.1056/NEJMoa1810527 10.1136/jitc-2019-000465 10.1007/s40265-015-0522-7 10.1038/mt.2011.113 |
ContentType | Journal Article |
Copyright | Copyright © 2021 Carter, Koch, Lauer and Hartkopf. Copyright © 2021 Carter, Koch, Lauer and Hartkopf 2021 Carter, Koch, Lauer and Hartkopf |
Copyright_xml | – notice: Copyright © 2021 Carter, Koch, Lauer and Hartkopf. – notice: Copyright © 2021 Carter, Koch, Lauer and Hartkopf 2021 Carter, Koch, Lauer and Hartkopf |
DBID | NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.3389/fonc.2021.803050 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic CrossRef |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 2234-943X |
EndPage | 803050 |
ExternalDocumentID | oai_doaj_org_article_c1fb03e4b2c047f4b6cad71d3627401a 10_3389_fonc_2021_803050 35004328 |
Genre | Journal Article Review |
GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD ACGFO ACGFS ACXDI ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK EBS EJD EMOBN GROUPED_DOAJ GX1 HYE IAO IEA IHR IHW IPNFZ KQ8 M48 M~E NPM OK1 PGMZT RIG RNS RPM AAYXX CITATION 7X8 ITC 5PM |
ID | FETCH-LOGICAL-c462t-6a95da3a245e42dc5dcde963b4b19a59bcbfa2f5d0c90f8602d71fb69f1c272d3 |
IEDL.DBID | RPM |
ISSN | 2234-943X |
IngestDate | Thu Jul 04 20:59:17 EDT 2024 Tue Sep 17 20:48:58 EDT 2024 Fri Aug 16 09:19:44 EDT 2024 Thu Sep 26 19:28:35 EDT 2024 Sat Sep 28 08:23:37 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | breast cancer clinical trials virotherapy oncolytic virus review |
Language | English |
License | Copyright © 2021 Carter, Koch, Lauer and Hartkopf. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c462t-6a95da3a245e42dc5dcde963b4b19a59bcbfa2f5d0c90f8602d71fb69f1c272d3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 This article was submitted to Breast Cancer, a section of the journal Frontiers in Oncology Reviewed by: Masmudur Mohammed Rahman, Arizona State University, United States; Konstantin Kousoulas, Louisiana State University, United States; Robert Kratzke, University of Minnesota Twin Cities, United States Edited by: Assia Konsoulova, Complex Oncological Center (Burgas), Bulgaria |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733599/ |
PMID | 35004328 |
PQID | 2618506276 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_c1fb03e4b2c047f4b6cad71d3627401a pubmedcentral_primary_oai_pubmedcentral_nih_gov_8733599 proquest_miscellaneous_2618506276 crossref_primary_10_3389_fonc_2021_803050 pubmed_primary_35004328 |
PublicationCentury | 2000 |
PublicationDate | 2021-12-23 |
PublicationDateYYYYMMDD | 2021-12-23 |
PublicationDate_xml | – month: 12 year: 2021 text: 2021-12-23 day: 23 |
PublicationDecade | 2020 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland |
PublicationTitle | Frontiers in oncology |
PublicationTitleAlternate | Front Oncol |
PublicationYear | 2021 |
Publisher | Frontiers Media S.A |
Publisher_xml | – name: Frontiers Media S.A |
References | Pesonen (B49) 2012; 130 Alexander (B66) 2000; 19 Kaufman (B91) 2010; 6 Kwan (B92) 2021; 13 Swain (B6) 2015; 372 Macedo (B93) 2020; 8 Ribas (B24) 2017; 170 Liu (B84) 2005; 12 Shay (B80) 2001; 10 Nemunaitis (B81) 2000; 60 Pecora (B54) 2002; 20 Hartkopf (B94) 2013; 130 Gianni (B18) 2020; 80 Cerullo (B48) 2011; 19 Andtbacka (B37) 2015; 33 Hartkopf (B30) 2012; 72 Larson (B78) 2015; 6 Nokisalmi (B50) 2010; 16 Pardoll (B8) 2012; 12 Schmid (B16) 2018; 379 Lichty (B35) 2014; 14 Chopra (B7) 2018; 13 Hemminki (B46) 2015; 6 Kaufman (B36) 2015; 14 Chaurasiya (B27) 2020; 9 Zamarin (B64) 2012; 7 O’shea (B86) 2005; 8 Chaurasiya (B63) 2021; 28 Russell (B9) 2012; 30 Sung (B83) 2001; 3 Cerullo (B47) 2010; 70 Strong (B69) 1993; 197 O'bryan (B60) 2018; 18 Ganar (B65) 2014; 184 Bramante (B45) 2016; 5 Zeh (B40) 2015; 23 Ben-Aharon (B21) 2018; 4 Roberts (B72) 2008; 16 Wold (B82) 1999; 11 Burgert (B85) 2002 Kimata (B56) 2006; 13 Farwell (B29) 2021; 62 Stojdl (B67) 2000; 6 Binz (B11) 2015; 4 Russell (B39) 2007; 28 Chu (B76) 2004; 10 Morris (B42) 2013; 31 Nemunaitis (B53) 2007; 14 Laurie (B55) 2006; 12 Siegel (B2) 2021; 71 Sharma (B22) 2017; 168 Smith (B71) 2002; 83 Rojas (B79) 2009; 16 Keenan (B14) 2020; 18 Garza-Morales (B26) 2018; 10 Lawler (B33) 2017; 3 Sahin (B58) 2012; 19 Fueyo (B87) 2000; 19 Li (B52) 2008; 16 Chalikonda (B75) 2007; 15 Turner (B4) 2018; 379 Nemunaitis (B51) 2010; 18 Society (B1) 2017 Huang (B88) 2003; 63 Andrea Mccart (B73) 2004; 10 Swain (B3) 2013; 14 García (B90) 2007; 89 Antonio Chiocca (B31) 2002; 2 Arab (B61) 2019; 234 Chakrabarty (B68) 2015; 33 Gollamudi (B41) 2010; 28 Heise (B77) 2000; 105 Kanerva (B44) 2013; 19 Hartkopf (B10) 2011; 123 Martuza (B32) 1991; 252 Schmid (B19) 2020; 382 Hu (B59) 2006; 12 Ushijima (B70) 2007; 9 Martini (B62) 2020; 14 Hartkopf (B13) 2016; 11 Jin (B28) 2021; 9 Liu (B89) 2003; 10 Cortes (B17) 2020; 396 Nakao (B57) 2007; 7 Im (B5) 2019; 381 Torres (B23) 2021 Harbeck (B12) 2017; 389 Chiocca (B34) 2014; 2 Winer (B15) 2021; 22 Greig (B38) 2016; 76 Niavarani (B25) 2020; 8 Bernstein (B43) 2018; 167 Miles (B20) 2021; 32 Mccart (B74) 2001; 61 |
References_xml | – volume: 12 start-page: 6737 year: 2006 ident: B59 article-title: A Phase I Study of OncoVEX GM-CSF, a Second-Generation Oncolytic Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating Factor publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-06-0759 contributor: fullname: Hu – year: 2021 ident: B23 article-title: Emerging Combination Immunotherapy Strategies for Breast Cancer: Dual Immune Checkpoint Modulation, Antibody-Drug Conjugates and Bispecific Antibodies publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-021-06423-0 contributor: fullname: Torres – volume: 10 year: 2004 ident: B73 article-title: Oncolytic Vaccinia Virus Expressing the Human Somatostatin Receptor SSTR2: Molecular Imaging After Systemic Delivery Using 111in-Pentetreotide publication-title: Mol Ther doi: 10.1016/j.ymthe.2004.06.158 contributor: fullname: Andrea Mccart – volume: 13 year: 2018 ident: B7 article-title: Annual Congress of the European Society for Medical Oncology (ESMO): Munich, Germany, 19–23 October 2018 publication-title: Targeted Oncol doi: 10.1007/s11523-018-0608-8 contributor: fullname: Chopra – volume: 13 year: 2006 ident: B56 article-title: Pilot Study of Oncolytic Viral Therapy Using Mutant Herpes Simplex Virus (HF10) Against Recurrent Metastatic Breast Cancer publication-title: Ann Surg Oncol doi: 10.1245/ASO.2006.08.035 contributor: fullname: Kimata – volume: 10 start-page: 292 year: 2003 ident: B89 article-title: ICP34.5 Deleted Herpes Simplex Virus With Enhanced Oncolytic, Immune Stimulating, and Anti-Tumour Properties publication-title: Gene Ther doi: 10.1038/sj.gt.3301885 contributor: fullname: Liu – volume: 12 start-page: 2555 year: 2006 ident: B55 article-title: A Phase 1 Clinical Study of Intravenous Administration of PV701, an Oncolytic Virus, Using Two-Step Desensitization publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-05-2038 contributor: fullname: Laurie – volume: 18 year: 2010 ident: B51 article-title: A Phase I Study of Telomerase-Specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors publication-title: Mol Ther J Am Soc Gene Ther doi: 10.1038/mt.2009.262 contributor: fullname: Nemunaitis – volume: 7 year: 2012 ident: B64 article-title: Oncolytic Newcastle Disease Virus for Cancer Therapy: Old Challenges and New Directions publication-title: Future Microbiol doi: 10.2217/fmb.12.4 contributor: fullname: Zamarin – volume: 71 start-page: 7 year: 2021 ident: B2 article-title: Cancer Statistics 2021 publication-title: CA Cancer J Clin doi: 10.3322/caac.21654 contributor: fullname: Siegel – volume: 60 start-page: 6359 year: 2000 ident: B81 article-title: Selective Replication and Oncolysis in P53 Mutant Tumors With ONYX-015, an E1B-55kd Gene-Deleted Adenovirus, in Patients With Advanced Head and Neck Cancer: A Phase II Trial publication-title: Cancer Res contributor: fullname: Nemunaitis – volume: 30 start-page: 658 year: 2012 ident: B9 article-title: Oncolytic Virotherapy publication-title: Nat Biotechnol doi: 10.1038/nbt.2287 contributor: fullname: Russell – volume: 6 year: 2015 ident: B46 article-title: Immunological Data From Cancer Patients Treated With Ad5/3-E2F-Δ24-GMCSF Suggests Utility for Tumor Immunotherapy publication-title: Oncotarget doi: 10.18632/oncotarget.2901 contributor: fullname: Hemminki – volume: 6 year: 2010 ident: B91 article-title: OPTIM Trial: A Phase III Trial of an Oncolytic Herpes Virus Encoding GM-CSF for Unresectable Stage III or IV Melanoma publication-title: Future Oncol doi: 10.2217/fon.10.66 contributor: fullname: Kaufman – volume: 80 start-page: GS3 year: 2020 ident: B18 article-title: Abstract GS3-04: Pathologic Complete Response (pCR) to Neoadjuvant Treatment With or Without Atezolizumab in Triple Negative, Early High-Risk and Locally Advanced Breast Cancer. NeoTRIPaPDL1 Michelangelo Randomized Study publication-title: Cancer Res doi: 10.1158/1538-7445.Sabcs19-gs3-04 contributor: fullname: Gianni – volume: 5 start-page: e1078057 year: 2016 ident: B45 article-title: Oncolytic Virotherapy for Treatment of Breast Cancer, Including Triple-Negative Breast Cancer publication-title: OncoImmunology doi: 10.1080/2162402X.2015.1078057 contributor: fullname: Bramante – volume: 12 year: 2005 ident: B84 article-title: Functional Interactions of Antiapoptotic Proteins and Tumor Necrosis Factor in the Context of a Replication-Competent Adenovirus publication-title: Gene Ther doi: 10.1038/sj.gt.3302555 contributor: fullname: Liu – volume: 10 start-page: 144 year: 2018 ident: B26 article-title: Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro publication-title: Cancers doi: 10.3390/cancers10050144 contributor: fullname: Garza-Morales – volume: 167 year: 2018 ident: B43 article-title: A Randomized Phase II Study of Weekly Paclitaxel With or Without Pelareorep in Patients With Metastatic Breast Cancer: Final Analysis of Canadian Cancer Trials Group IND.213 publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-017-4538-4 contributor: fullname: Bernstein – volume: 18 start-page: 192 year: 2018 ident: B60 article-title: Oncolytic Virotherapy for Breast Cancer Treatment publication-title: Curr Gene Ther doi: 10.2174/1566523218666180910163805 contributor: fullname: O'bryan – volume: 3 year: 2017 ident: B33 article-title: Oncolytic Viruses in Cancer Treatment: A Review publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2016.2064 contributor: fullname: Lawler – volume: 14 start-page: 885 year: 2007 ident: B53 article-title: A Phase I Trial of Intravenous Infusion of ONYX-015 and Enbrel in Solid Tumor Patients publication-title: Cancer Gene Ther doi: 10.1038/sj.cgt.7701080 contributor: fullname: Nemunaitis – volume-title: Breast Cancer Facts & 017-2018 year: 2017 ident: B1 contributor: fullname: Society – volume: 19 year: 2013 ident: B44 article-title: Antiviral and Antitumor T-Cell Immunity in Patients Treated With GM-CSF–Coding Oncolytic Adenovirus publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-12-2546 contributor: fullname: Kanerva – volume: 16 year: 2008 ident: B72 article-title: Vaccinia Virus Morphogenesis and Dissemination publication-title: Trends Microbiol doi: 10.1016/j.tim.2008.07.009 contributor: fullname: Roberts – volume: 10 start-page: 5299 year: 2004 ident: B76 article-title: Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-0349-03 contributor: fullname: Chu – volume: 389 year: 2017 ident: B12 article-title: Breast Cancer publication-title: Lancet doi: 10.1016/S0140-6736(16)31891-8 contributor: fullname: Harbeck – volume: 2 start-page: 938 year: 2002 ident: B31 article-title: Oncolytic Viruses publication-title: Nat Rev Cancer doi: 10.1038/nrc948 contributor: fullname: Antonio Chiocca – volume: 105 year: 2000 ident: B77 article-title: Replication-Selective Adenoviruses as Oncolytic Agents publication-title: J Clin Invest doi: 10.1172/JCI9762 contributor: fullname: Heise – volume: 23 year: 2015 ident: B40 article-title: First-In-Man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity publication-title: Mol Ther J Am Soc Gene Ther doi: 10.1038/mt.2014.194 contributor: fullname: Zeh – volume: 33 year: 2015 ident: B37 article-title: Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma publication-title: J Clin Oncol doi: 10.1200/JCO.2014.58.3377 contributor: fullname: Andtbacka – volume: 15 start-page: 115 year: 2007 ident: B75 article-title: Oncolytic Virotherapy for Ovarian Carcinomatosis Using a Replication-Selective Vaccinia Virus Armed With a Yeast Cytosine Deaminase Gene publication-title: Cancer Gene Ther doi: 10.1038/sj.cgt.7701110 contributor: fullname: Chalikonda – volume: 14 start-page: 559 year: 2014 ident: B35 article-title: Going Viral With Cancer Immunotherapy publication-title: Nat Rev Cancer doi: 10.1038/nrc3770 contributor: fullname: Lichty – volume: 16 year: 2010 ident: B50 article-title: Oncolytic Adenovirus ICOVIR-7 in Patients With Advanced and Refractory Solid Tumors publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-09-3167 contributor: fullname: Nokisalmi – volume: 11 year: 1999 ident: B82 article-title: Immune Responses to Adenoviruses: Viral Evasion Mechanisms and Their Implications for the Clinic publication-title: Curr Opin Immunol doi: 10.1016/S0952-7915(99)80064-8 contributor: fullname: Wold – volume: 62 start-page: jnumed.121.262485 year: 2021 ident: B29 article-title: CD8-Targeted PET Imaging of Tumor Infiltrating T Cells in Patients With Cancer: A Phase I First-In-Human Study of 89Zr-Df-IAB22M2C, a Radiolabeled Anti-CD8 Minibody publication-title: J Nucl Med doi: 10.2967/jnumed.121.262485 contributor: fullname: Farwell – volume: 18 year: 2020 ident: B14 article-title: Role of Immunotherapy in Triple-Negative Breast Cancer publication-title: J Natl Compr Cancer Network J Natl Compr Canc Netw doi: 10.6004/jnccn.2020.7554 contributor: fullname: Keenan – volume: 63 start-page: 7321 year: 2003 ident: B88 article-title: A Broadly Applicable, Personalized Heat Shock Protein-Mediated Oncolytic Tumor Vaccine publication-title: Cancer Res contributor: fullname: Huang – start-page: 273 volume-title: Viral Proteins Counteracting Host Defenses year: 2002 ident: B85 article-title: Subversion of Host Defense Mechanisms by Adenoviruses doi: 10.1007/978-3-642-59421-2_16 contributor: fullname: Burgert – volume: 70 year: 2010 ident: B47 article-title: Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-3567 contributor: fullname: Cerullo – volume: 14 start-page: 642 year: 2015 ident: B36 article-title: Oncolytic Viruses: A New Class of Immunotherapy Drugs publication-title: Nat Rev Drug Discov doi: 10.1038/nrd4663 contributor: fullname: Kaufman – volume: 20 year: 2002 ident: B54 article-title: Phase I Trial of Intravenous Administration of PV701, an Oncolytic Virus, in Patients With Advanced Solid Cancers publication-title: J Clin Oncol doi: 10.1200/JCO.2002.08.042 contributor: fullname: Pecora – volume: 72 year: 2012 ident: B30 article-title: Oncolytic Viruses to Treat Ovarian Cancer Patients - a Review of Results From Clinical Trials publication-title: Geburtshilfe und Frauenheilkunde doi: 10.1055/s-0031-1298281 contributor: fullname: Hartkopf – volume: 13 start-page: 1128 year: 2021 ident: B92 article-title: Oncolytic Virotherapy Treatment of Breast Cancer: Barriers and Recent Advances publication-title: Viruses doi: 10.3390/v13061128 contributor: fullname: Kwan – volume: 130 year: 2012 ident: B49 article-title: Integrin Targeted Oncolytic Adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for Treatment of Patients With Advanced Chemotherapy Refractory Solid Tumors publication-title: Int J Cancer doi: 10.1002/ijc.26216 contributor: fullname: Pesonen – volume: 28 year: 2007 ident: B39 article-title: Viruses as Anticancer Drugs publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2007.05.005 contributor: fullname: Russell – volume: 184 start-page: 71 year: 2014 ident: B65 article-title: Newcastle Disease Virus: Current Status and Our Understanding publication-title: Virus Res doi: 10.1016/j.virusres.2014.02.016 contributor: fullname: Ganar – volume: 22 start-page: 499 year: 2021 ident: B15 article-title: Pembrolizumab Versus Investigator-Choice Chemotherapy for Metastatic Triple-Negative Breast Cancer (KEYNOTE-119): A Randomised, Open-Label, Phase 3 Trial publication-title: Lancet Oncol doi: 10.1016/S1470-2045(20)30754-3 contributor: fullname: Winer – volume: 396 year: 2020 ident: B17 article-title: Pembrolizumab Plus Chemotherapy Versus Placebo Plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple-Negative Breast Cancer (KEYNOTE-355): A Randomised, Placebo-Controlled, Double-Blind, Phase 3 Clinical Trial publication-title: Lancet doi: 10.1016/S0140-6736(20)32531-9 contributor: fullname: Cortes – volume: 6 year: 2015 ident: B78 article-title: Going Viral: A Review of Replication-Selective Oncolytic Adenoviruses publication-title: Oncotarget doi: 10.18632/oncotarget.5116 contributor: fullname: Larson – volume: 19 year: 2000 ident: B66 article-title: Newcastle Disease and Other Avian Paramyxoviruses publication-title: Rev Scientifique Technique-Office Int Des Epizooties doi: 10.20506/rst.19.2.1231 contributor: fullname: Alexander – volume: 372 year: 2015 ident: B6 article-title: Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer publication-title: N Eng J Med doi: 10.1056/NEJMoa1413513 contributor: fullname: Swain – volume: 168 year: 2017 ident: B22 article-title: Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy publication-title: Cell doi: 10.1016/j.cell.2017.01.017 contributor: fullname: Sharma – volume: 12 start-page: 252 year: 2012 ident: B8 article-title: The Blockade of Immune Checkpoints in Cancer Immunotherapy publication-title: Nat Rev Cancer doi: 10.1038/nrc3239 contributor: fullname: Pardoll – volume: 9 year: 2007 ident: B70 article-title: Determination and Analysis of the DNA Sequence of Highly Attenuated Herpes Simplex Virus Type 1 Mutant HF10, a Potential Oncolytic Virus publication-title: Microbes Infection doi: 10.1016/j.micinf.2006.10.019 contributor: fullname: Ushijima – volume: 130 year: 2013 ident: B94 article-title: Enhanced Killing of Ovarian Carcinoma Using Oncolytic Measles Vaccine Virus Armed With a Yeast Cytosine Deaminase and Uracil Phosphoribosyltransferase publication-title: Gynecologic Oncol doi: 10.1016/j.ygyno.2013.05.004 contributor: fullname: Hartkopf – volume: 19 start-page: 2 year: 2000 ident: B87 article-title: A Mutant Oncolytic Adenovirus Targeting the Rb Pathway Produces Anti-Glioma Effect In Vivo publication-title: Oncogene doi: 10.1038/sj.onc.1203251 contributor: fullname: Fueyo – volume: 8 start-page: e001486 year: 2020 ident: B93 article-title: Clinical Landscape of Oncolytic Virus Research in 2020 publication-title: J Immunother Cancer doi: 10.1136/jitc-2020-001486 contributor: fullname: Macedo – volume: 252 start-page: 854 year: 1991 ident: B32 article-title: Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant publication-title: Science doi: 10.1126/science.1851332 contributor: fullname: Martuza – volume: 170 start-page: 1109 year: 2017 ident: B24 article-title: Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy publication-title: Cell doi: 10.1016/j.cell.2017.08.027 contributor: fullname: Ribas – volume: 2 start-page: 295 year: 2014 ident: B34 article-title: Oncolytic Viruses and Their Application to Cancer Immunotherapy publication-title: Cancer Immunol Res doi: 10.1158/2326-6066.CIR-14-0015 contributor: fullname: Chiocca – volume: 7 year: 2007 ident: B57 article-title: Clinical Experiment of Mutant Herpes Simplex Virus HF10 Therapy for Cancer publication-title: Curr Cancer Drug Targets doi: 10.2174/156800907780058808 contributor: fullname: Nakao – volume: 234 year: 2019 ident: B61 article-title: The Viral Approach to Breast Cancer Immunotherapy publication-title: Jounal Cell Physiol doi: 10.1002/jcp.27150 contributor: fullname: Arab – volume: 83 year: 2002 ident: B71 article-title: The Formation and Function of Extracellular Enveloped Vaccinia Virus publication-title: J Gen Virol doi: 10.1099/0022-1317-83-12-2915 contributor: fullname: Smith – volume: 33 year: 2015 ident: B68 article-title: The Oncolytic Virus, Pelareorep, as a Novel Anticancer Agent: A Review publication-title: Investigational New Drugs doi: 10.1007/s10637-015-0216-8 contributor: fullname: Chakrabarty – volume: 379 year: 2018 ident: B16 article-title: Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer publication-title: New Eng J Med doi: 10.1056/NEJMoa1809615 contributor: fullname: Schmid – volume: 16 start-page: 1441 year: 2009 ident: B79 article-title: A Modified E2F-1 Promoter Improves the Efficacy to Toxicity Ratio of Oncolytic Adenoviruses publication-title: Gene Ther doi: 10.1038/gt.2009.103 contributor: fullname: Rojas – volume: 28 year: 2010 ident: B41 article-title: Intravenous Administration of Reolysin, a Live Replication Competent RNA Virus Is Safe in Patients With Advanced Solid Tumors publication-title: Investigational New Drugs doi: 10.1007/s10637-009-9279-8 contributor: fullname: Gollamudi – volume: 16 start-page: 376 year: 2008 ident: B52 article-title: A Phase I Trial of Intratumoral Administration of Recombinant Oncolytic Adenovirus Overexpressing HSP70 in Advanced Solid Tumor Patients publication-title: Gene Ther doi: 10.1038/gt.2008.179 contributor: fullname: Li – volume: 32 start-page: 994 year: 2021 ident: B20 article-title: Primary Results From IMpassion131, a Double-Blind, Placebo-Controlled, Randomised Phase III Trial of First-Line Paclitaxel With or Without Atezolizumab for Unresectable Locally Advanced/Metastatic Triple-Negative Breast Cancer publication-title: Ann Oncol doi: 10.1016/j.annonc.2021.05.801 contributor: fullname: Miles – volume: 197 year: 1993 ident: B69 article-title: Evidence That the Epidermal Growth Factor Receptor on Host Cells Confers Reovirus Infection Efficiency publication-title: Virology doi: 10.1006/viro.1993.1602 contributor: fullname: Strong – volume: 89 start-page: 799 year: 2007 ident: B90 article-title: The dsRNA Protein Kinase PKR: Virus and Cell Control publication-title: Biochimie doi: 10.1016/j.biochi.2007.03.001 contributor: fullname: García – volume: 28 year: 2021 ident: B63 article-title: Viroimmunotherapy for Breast Cancer: Promises, Problems and Future Directions publication-title: Cancer Gene Ther doi: 10.1038/s41417-020-00265-6 contributor: fullname: Chaurasiya – volume: 10 year: 2001 ident: B80 article-title: Telomerase and Cancer publication-title: Hum Mol Genet doi: 10.1093/hmg/10.7.677 contributor: fullname: Shay – volume: 19 year: 2012 ident: B58 article-title: Impact of Novel Oncolytic Virus HF10 on Cellular Components of the Tumor Microenviroment in Patients With Recurrent Breast Cancer publication-title: Cancer Gene Ther doi: 10.1038/cgt.2011.80 contributor: fullname: Sahin – volume: 382 year: 2020 ident: B19 article-title: Pembrolizumab for Early Triple-Negative Breast Cancer publication-title: N Engl J Med doi: 10.1056/NEJMoa1910549 contributor: fullname: Schmid – volume: 123 year: 2011 ident: B10 article-title: Oncolytic Virotherapy of Breast Cancer publication-title: Gynecologic Oncol doi: 10.1016/j.ygyno.2011.06.021 contributor: fullname: Hartkopf – volume: 14 year: 2020 ident: B62 article-title: Oncolytic Virotherapy: New Weapon for Breast Cancer Treatment publication-title: Ecancermedicalscience doi: 10.3332/ecancer.2020.1149 contributor: fullname: Martini – volume: 9 start-page: 1729300 year: 2020 ident: B27 article-title: Oncolytic Poxvirus CF33-hNIS-ΔF14.5 Favorably Modulates Tumor Immune Microenvironment and Works Synergistically With Anti-PD-L1 Antibody in a Triple-Negative Breast Cancer Model publication-title: OncoImmunology doi: 10.1080/2162402X.2020.1729300 contributor: fullname: Chaurasiya – volume: 381 year: 2019 ident: B5 article-title: Overall Survival With Ribociclib Plus Endocrine Therapy in Breast Cancer publication-title: N Engl J Med doi: 10.1056/NEJMoa1903765 contributor: fullname: Im – volume: 3 year: 2001 ident: B83 article-title: Tnfα and Ifnγ Induced by Innate Anti-Adenoviral Immune Responses Inhibit Adenovirus-Mediated Transgene Expression publication-title: Mol Ther doi: 10.1006/mthe.2001.0318 contributor: fullname: Sung – volume: 8 start-page: 61 year: 2005 ident: B86 article-title: Heat Shock Phenocopies E1B-55K Late Functions and Selectively Sensitizes Refractory Tumor Cells to ONYX-015 Oncolytic Viral Therapy publication-title: Cancer Cell doi: 10.1016/j.ccr.2005.06.009 contributor: fullname: O’shea – volume: 4 start-page: 39 year: 2015 ident: B11 article-title: Chemovirotherapy: Combining Chemotherapeutic Treatment With Oncolytic Virotherapy publication-title: Oncolytic Virotherapy doi: 10.2147/OV.S54780 contributor: fullname: Binz – volume: 6 start-page: 821 year: 2000 ident: B67 article-title: Exploiting Tumor-Specific Defects in the Interferon Pathway With a Previously Unknown Oncolytic Virus publication-title: Nat Med doi: 10.1038/77558 contributor: fullname: Stojdl – volume: 31 start-page: 696 year: 2013 ident: B42 article-title: REO-001: A Phase I Trial of Percutaneous Intralesional Administration of Reovirus Type 3 Dearing (Reolysin®) in Patients With Advanced Solid Tumors publication-title: Investigational New Drugs doi: 10.1007/s10637-012-9865-z contributor: fullname: Morris – volume: 4 year: 2018 ident: B21 article-title: Association of Immunotherapy With Durable Survival as Defined by Value Frameworks for Cancer Care publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2017.4445 contributor: fullname: Ben-Aharon – volume: 14 year: 2013 ident: B3 article-title: Pertuzumab, Trastuzumab, and Docetaxel for HER2-Positive Metastatic Breast Cancer (CLEOPATRA Study): Overall Survival Results From a Randomised, Double-Blind, Placebo-Controlled, Phase 3 Study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(13)70130-X contributor: fullname: Swain – volume: 9 start-page: 71 year: 2021 ident: B28 article-title: Oncolytic Viruses for Triple Negative Breast Cancer and Beyond publication-title: Biomark Res doi: 10.1186/s40364-021-00318-4 contributor: fullname: Jin – volume: 11 year: 2016 ident: B13 article-title: PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer publication-title: Breast Care (Basel Switzerland) doi: 10.1159/000453569 contributor: fullname: Hartkopf – volume: 61 start-page: 8751 year: 2001 ident: B74 article-title: Systemic Cancer Therapy With a Tumor-Selective Vaccinia Virus Mutant Lacking Thymidine Kinase and Vaccinia Growth Factor Genes publication-title: Cancer Res contributor: fullname: Mccart – volume: 379 year: 2018 ident: B4 article-title: Overall Survival With Palbociclib and Fulvestrant in Advanced Breast Cancer publication-title: N Engl J Med doi: 10.1056/NEJMoa1810527 contributor: fullname: Turner – volume: 8 start-page: e000465 year: 2020 ident: B25 article-title: Oncolytic Vesicular Stomatitis Virus-Based Cellular Vaccine Improves Triple-Negative Breast Cancer Outcome by Enhancing Natural Killer and CD8(+) T-Cell Functionality publication-title: J Immunother Cancer doi: 10.1136/jitc-2019-000465 contributor: fullname: Niavarani – volume: 76 year: 2016 ident: B38 article-title: Talimogene Laherparepvec: First Global Approval publication-title: Drugs doi: 10.1007/s40265-015-0522-7 contributor: fullname: Greig – volume: 19 year: 2011 ident: B48 article-title: Immunological Effects of Low-Dose Cyclophosphamide in Cancer Patients Treated With Oncolytic Adenovirus publication-title: Mol Ther doi: 10.1038/mt.2011.113 contributor: fullname: Cerullo |
SSID | ssj0000650103 |
Score | 2.3852978 |
SecondaryResourceType | review_article |
Snippet | Breast cancer is the second most common kind of cancer worldwide and oncolytic viruses may offer a new treatment approach. There are three different types of... |
SourceID | doaj pubmedcentral proquest crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 803050 |
SubjectTerms | breast cancer clinical trials Oncology oncolytic virus review virotherapy |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LSxxBEG5kD-IlRONjooYO5OJh3On39FElIgGTy654a_qJCzIb9nHIv0_X9Ci7QfCS6zzo4vtququmiq8Q-pZar5SVolbSsZoT7-q21bYmNHpGmRQkwg_9-5_ybsp_PIrHjVFf0BNW5IELcGNPkmtY5I76hqvEnfQ2KBIYDI1pSAmNiNhIpsoeLGCAQalL5ixMj9O8A8VCSi5b8PFm6xzq5frfijH_bZXcOHtuP6IPQ9CIr4qx-2gndgdo934oi39CYlD3fMaT3p_wPOFfXab4T34BP8wW62Vc4lmHr6EFfYVvgOrFIZrefp_c3NXDPITac0lXtbRaBMss5SJyGrwIPsT8ATnuiLZCO--SpUmExusmwXCpDFRyUifiqaKBHaFRN-_iCcIuSJq4p6FJiYvUWh9AaS9y3kQuhK3QxQs65neRvTA5XQAkDSBpAElTkKzQNcD3-hwIVvcXMo1moNG8R2OFvr6Ab7KDQ9XCdnG-Xpqc4oGqHlWyQseFjNelmOglBdsKqS2atmzZvtPNnnoR7VYxJrT-_D-MP0V7gAd0uVB2hkarxTqe51hl5b70bvkX8MXnng priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9tAEF1VICEuiLa0BNpqK_XCwam9n_YBoSYCoUopl6TittpPiBTZ4CQS_Ht2bAcIyomr7dWu3rz1zHjWbxD6FXIrpRY8kcLQhGXWJHle6CQj3lJCBc88fNAf_ROXE_b3ml-__B7dATjfmNpBP6lJPes_3D-exQ1_Chln9Le_Q1WCGCHJ-jnQNybw24RRBnwfdcF--17m0NSgrVVuHLiLdihvROryNTfVqPlvCkHfnqR85Zou9tFeF1PiPy0JPqIPvvyEdkZd1fwz4p345wyPG7rhKuCrMjLgMQ7A_6f1cu7neFriAZxQX-AhMKE-QJOL8_HwMunaJSSWCbJIhC6401QTxj0jznJnnY_7yzCTFZoXxpqgSeAutUUaoPeUk1kwogiZJZI4-gVtlVXpDxE2TpDALHFpCIyHXFsHQnyesdQzznUPnazQUXetKoaK2QSAqgBUBaCqFtQeGgB8z8-BnnVzoapvVLc9lI0LSalnhtiUycCMsDquzlFoDZRmccKfK_BV5D8UNXTpq-VcxQwQRPeIFD30tTXG81QrY_aQXDPT2lrW75TT20ZjO5eU8qI4evfIY7QLIMDJF0K_oa1FvfTfY_yyMD8aWj4B76_vlw priority: 102 providerName: Scholars Portal |
Title | Clinical Trials of Oncolytic Viruses in Breast Cancer |
URI | https://www.ncbi.nlm.nih.gov/pubmed/35004328 https://search.proquest.com/docview/2618506276 https://pubmed.ncbi.nlm.nih.gov/PMC8733599 https://doaj.org/article/c1fb03e4b2c047f4b6cad71d3627401a |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbaHhAXxJttoTISFw7ZTfyMj3RFqZAWOLRob5afsFLrVPs48O_rcZKqizhxsaIklkffTOKZzOQbhD7E1klpBK-ksLRijbNV2ypTNSQ4SqjgTYAP-otv4uKKfV3y5QHi478wpWjf2dU0Xd9M0-p3qa28vXGzsU5s9mMxbyWlXKnZITrMRw9C9P71y6F3QZ-SzAGYmsUuAVkhaaYtmDc0f6O8cNG1e7tRIe3_l6f5d8Hkgx3o_Cl6MriO-FMv4jN0ENJz9GgxJMdfID5wfF7jy2JVuIv4e8qK_pMn4J-r9W4TNniV8BkUom_xHBS-fomuzj9fzi-qoStC5Zgg20oYxb2hhjAeGPGOe-dDfowss40yXFlnoyGR-9qpOkKLKS-baIWKjSOSePoKHaUuhTcIWy9IZI74OkbGY2ucB769wFgdGOdmgj6O6OjbnvxC56ABQNUAqgZQdQ_qBJ0BfPf3AW11OdGtf-lBedplQWoamCWuZjIyK5zJ0nkKHYDqJi_4fgRfZzOH3IVJodttdA70gFuPSDFBr3tl3C81KnOC5J6a9mTZv5Itq1BpD5Z0_N8zT9BjAAEKXAh9i4626114l92UrT0t4X0evyybPC5Ye1oM9Q7KAOqi |
link.rule.ids | 230,315,733,786,790,870,891,2115,24346,27957,27958,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VIkEvvCnhaSQuHJzY-7SPNKIK0BQOadXbap8Q0dpV4hzg17PjR9VUXODq9WrH8816d7yfvwF4FworpRY8lcLQlOXWpEVR6jQn3lJCBc89ftCfH4vZCft8xs92gA__wrSkfWuW4-r8Ylwtf7TcyssLOxl4YpNv82khKeVlObkFt-N8JfJakt69gDlWL-gOJWMKVk5CXaFcIcnHBQY4ln-jvFWjK7bWo1a2_297zZuUyWtr0OF9OB2s76gnP8ebxozt7xvCjv_8eA_gXr8rTT50zQ9hx1eP4M68P3d_DLyXDz1PFm3AJnVIvlYxhn7FDsnpcrVZ-3WyrJID5Lg3yRRjafUETg4_LqaztC-4kFomSJMKXXKnqSaMe0ac5c46H2eoYSYvNS-NNUGTwF1myyxg9Son82BEGXJLJHH0KexWdeWfQWKcIIFZ4rIQGA-Ftg6l_DxjmWec6xG8H9yuLjtdDRXzEURLIVoK0VIdWiM4QFyu7kNF7PZCvfquescpGw3JqGeG2IzJwIywOlrnKBYXyvI44NsBVRVnEB6L6MrXm7WKOSTK9hEpRrDfoXw11BAlI5Bb-G_Zst0SUW1VunsUn_93zzdwd7aYH6mjT8dfXsAeOgR5NIS-hN1mtfGv4m6oMa_b2P8D5f8J9Q |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JbxMxGLWgSBUX9iWsg8SFw2xex0caiMqS0kOLKi6WV4hoZ6JkcoBfj79ZqqTi1OuMLS_veexv_PQ-hN6GygqhOUsFNySlpTVpVUmdlthbgglnpYcf-vMjfnhKP5-xs61UX51o35pFVp9fZPXiV6etXF7YfNSJ5cfzaSUIYVLmSxfym-hWXLNYbgXq_UeYQQaD_mIyhmEyD00NloW4zCogOaSAI6xzpKt29qTOuv9_582rssmtfWh2F_0YR9DLT35nm9Zk9u8Vc8drDfEeujOcTpP3fZH76IavH6D9-XD__hCxwUb0PDnpiJs0IflWRy79iRWS74vVZu3XyaJODkDr3iZT4NTqETqdfTyZHqZD4oXUUo7blGvJnCYaU-YpdpY563xcqYaaUmomjTVB48BcYWURIIuVE2UwXIbSYoEdeYz26qb2T1FiHMeBWuyKECgLlbYOLP08pYWnjOkJejdOvVr2_hoqxiWAmALEFCCmesQm6ACwuSwHztjdg2b1Uw2Tp2zsSEE8NdgWVARquNWxd45AkqGijA2-GZFVcSXB9YiufbNZqxhLgn0fFnyCnvRIXzY1MmWCxA4Hdvqy-yYi27l1D0g-u3bN12j_-MNMff109OU5ug3zAXIaTF6gvXa18S_joag1rzr6_wM9agx1 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+Trials+of+Oncolytic+Viruses+in+Breast+Cancer&rft.jtitle=Frontiers+in+oncology&rft.au=Carter%2C+Mary+E.&rft.au=Koch%2C+Andr%C3%A9&rft.au=Lauer%2C+Ulrich+M.&rft.au=Hartkopf%2C+Andreas+D.&rft.date=2021-12-23&rft.pub=Frontiers+Media+S.A&rft.eissn=2234-943X&rft.volume=11&rft_id=info:doi/10.3389%2Ffonc.2021.803050&rft_id=info%3Apmid%2F35004328&rft.externalDBID=PMC8733599 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon |