Luteolin Attenuates Allergic Nasal Inflammation via Inhibition of Interleukin-4 in an Allergic Rhinitis Mouse Model and Peripheral Blood From Human Subjects With Allergic Rhinitis

• Published in: Frontiers in pharmacology Vol. 11; p. 291
• Main Authors: Liang, Kai-Li, Yu, Sheng-Jie, Huang, Wan-Chun, Yen, Hung-Rong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.03.2020
• Subjects: allergic rhinitis; IL-4; luteolin; Pharmacology; traditional Chinese medicine; type 2 helper T cells; IL-4; luteolin; traditional Chinese medicine; allergic rhinitis; type 2 helper T cells

Luteolin is the active component of , an herb for the treatment of allergy in Asia. In this study, we aimed to investigate the effects and mechanisms of luteolin treatment. BALB/c mice sensitized with house dust mite (HDM) to induce allergic rhinitis (AR), and treated with dexamethasone or luteolin....