Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries

• Published in: Frontiers in physiology Vol. 9; p. 856
• Main Authors: Seawright, John W, Sreenivasappa, Harini, Gibbs, Holly C, Padgham, Samuel, Shin, Song Y, Chaponnier, Christine, Yeh, Alvin T, Trzeciakowski, Jerome P, Woodman, Christopher R, Trache, Andreea
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 31.07.2018
• Subjects: aging; atomic force microscopy; Physiology; Rho-kinase; vascular smooth muscle; vasoconstriction; Rho-kinase; vasoconstriction; vascular smooth muscle; aging; atomic force microscopy

Aging induces a progressive decline in vasoconstrictor responses in central and peripheral arteries. This study investigated the hypothesis that vascular smooth muscle (VSM) contractile function declines with age in soleus muscle feed arteries (SFA). Contractile function of cannulated SFA isolated f...