Regulation and function of the mammalian tricarboxylic acid cycle

• Published in: The Journal of biological chemistry Vol. 299; no. 2; p. 102838
• Main Authors: Arnold, Paige K., Finley, Lydia W.S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2023
• Subjects: Animals; bioenergetics; cell metabolism; citric acid cycle; Citric Acid Cycle - physiology; Energy Metabolism; Krebs cycle; Mammals; tricarboxylic acid cycle; αKG; MPC; FH; TET; OXPHOS; GDH; PDHC; IDH; Krebs cycle; LDH; LDHA; bioenergetics; ESC; CPT1; PDK; SDH; ISC; cell metabolism; ACSS; PDP; d-2HG; HIF; MDH1; MDH2; GOT2; ACL; ACO; CCL; OAA; HFSC; CS; tricarboxylic acid cycle; citric acid cycle; PC; TCA; ETC; rTCA; ROS; OGDH; GPD; BCAT1; IRE

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that performs the essential function of oxidizing nutrients to support cellular bioenergetics. More recently, it has become evident that TCA cycle behavior is dynamic, and products of the TCA cycle...