Imbalance of Controlled Death in Peripheral Blood Lymphocytes in Crohn’s Disease and Ulcerative Colitis

• Published in: Medicina (Kaunas, Lithuania) Vol. 55; no. 6; p. 231
• Main Authors: Dudzińska, Ewa, Szymona, Kinga, Gil-Kulik, Paulina, Chomik, Piotr, Świstowska, Małgorzata, Gryzińska, Magdalena, Kocki, Janusz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 31.05.2019; MDPI AG
• Subjects: Adult; Aged; apoptosis; bcl-2-Associated X Protein - genetics; Caspase 3 - genetics; Caspase 9 - genetics; Cell Death - genetics; Cell Death - physiology; Colitis, Ulcerative - blood; Colitis, Ulcerative - genetics; Colitis, Ulcerative - physiopathology; Crohn Disease - blood; Crohn Disease - genetics; Crohn Disease - physiopathology; Crohn’s disease; Female; Humans; Intestinal Mucosa - physiopathology; Lymphocytes - pathology; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2 - genetics; ulcerative colitis; apoptosis; ulcerative colitis; Crohn’s disease

Background and objectives: Inflammatory bowel disease (IBD) mainly includes Crohn’s disease (CD) and ulcerative colitis (UC). Both conditions are associated with an exacerbated intestinal immune response to harmless stimuli, leading to upregulation of pro-inflammatory mediators. Materials and Method...