Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer

• Published in: Frontiers in immunology Vol. 11; p. 2039
• Main Authors: Lin, Anqi, Zhang, Jian, Luo, Peng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.08.2020
• Subjects: colon adenocarcinoma; Colorectal cancer; Colorectal Neoplasms - etiology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Computational Biology - methods; Disease Management; Disease Susceptibility; DNA Damage; Female; Gene Expression Profiling; Humans; immune checkpoint inhibitors; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunology; Immunomodulation - genetics; Male; Microsatellite Instability; Molecular Targeted Therapy; Mutation; Prognosis; rectum adenocarcinoma; Signal Transduction; Transcriptome; Treatment Outcome; tumor microenvironment; Tumor Microenvironment - drug effects; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; microsatellite instability; immune checkpoint inhibitors; tumor microenvironment; colon adenocarcinoma; rectum adenocarcinoma; Colorectal cancer

Colorectal cancer (CRC) patients, especially those with deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) tumors, whose sensitivity to immune checkpoint inhibitors (ICIs) is significantly higher than that of patients with microsatellite-stable (MSS)/microsatellite instability-...