Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration

A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in...

Full description

Saved in:
Bibliographic Details
Published inStem cells international Vol. 2024; no. 1; p. 2812390
Main Authors Zhang, Meng-Han, Yu, Li-Ming, Zhang, Wei-Hua, Deng, Jia-Jia, Sun, Bing-Jing, Chen, Mei-Hua, Huang, Wei, Li, Jiao, He, Hua, Han, Xin-Xin, Liu, Yue-Hua
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.01.2024
Wiley
Subjects
Antibodies
Biomarkers
Bone growth
Bone morphogenetic proteins
Cell cycle
Cell differentiation
Dental pulp
Muscles
Musculoskeletal system
MyoD protein
Myogenesis
Myotubes
Neuromuscular diseases
Noggin protein
Regeneration
Satellite cells
Skeletal muscle
Smad protein
Stem cell transplantation
Stem cells
Tibialis anterior muscle
United States
China
Beijing China
United States > US
Online AccessGet full text

Cover

Abstract A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in muscle regeneration due to the unknown induction mechanism. In this study, we treated human DPSCs with Noggin, a secreted antagonist of bone morphogenetic protein (BMP), and discovered that Noggin can effectively promote myotube formation. We also found that Noggin can accelerate the skeletal myogenic differentiation (MyoD) of DPSCs and promote the generation of Pax7 + satellite‐like cells. Noggin increased the expression of myogenic markers and the transcriptional and translational abundance of satellite cell (SC) markers in DPSCs. Moreover, BMP4 inhibited Pax7 expression and activated p‐Smad1/5/9, while Noggin eliminated BMP4‐induced p‐Smad1/5/9 in DPSCs. This finding suggests that Noggin antagonizes BMP by downregulating p‐Smad and facilitates the MyoD of DPSCs. Then, we implanted Noggin‐pretreated DPSCs combined with Matrigel into the mouse tibialis anterior muscle with volumetric muscle loss (VML) and observed a 73% reduction in the size of the defect and a 69% decrease in scar tissue. Noggin‐treated DPSCs can benefit the Pax7 + SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite‐like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite‐like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.
AbstractList A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in muscle regeneration due to the unknown induction mechanism. In this study, we treated human DPSCs with Noggin, a secreted antagonist of bone morphogenetic protein (BMP), and discovered that Noggin can effectively promote myotube formation. We also found that Noggin can accelerate the skeletal myogenic differentiation (MyoD) of DPSCs and promote the generation of Pax7 + satellite-like cells. Noggin increased the expression of myogenic markers and the transcriptional and translational abundance of satellite cell (SC) markers in DPSCs. Moreover, BMP4 inhibited Pax7 expression and activated p-Smad1/5/9, while Noggin eliminated BMP4-induced p-Smad1/5/9 in DPSCs. This finding suggests that Noggin antagonizes BMP by downregulating p-Smad and facilitates the MyoD of DPSCs. Then, we implanted Noggin-pretreated DPSCs combined with Matrigel into the mouse tibialis anterior muscle with volumetric muscle loss (VML) and observed a 73% reduction in the size of the defect and a 69% decrease in scar tissue. Noggin-treated DPSCs can benefit the Pax7 + SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite-like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite-like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.
A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in muscle regeneration due to the unknown induction mechanism. In this study, we treated human DPSCs with Noggin, a secreted antagonist of bone morphogenetic protein (BMP), and discovered that Noggin can effectively promote myotube formation. We also found that Noggin can accelerate the skeletal myogenic differentiation (MyoD) of DPSCs and promote the generation of Pax7+ satellite-like cells. Noggin increased the expression of myogenic markers and the transcriptional and translational abundance of satellite cell (SC) markers in DPSCs. Moreover, BMP4 inhibited Pax7 expression and activated p-Smad1/5/9, while Noggin eliminated BMP4-induced p-Smad1/5/9 in DPSCs. This finding suggests that Noggin antagonizes BMP by downregulating p-Smad and facilitates the MyoD of DPSCs. Then, we implanted Noggin-pretreated DPSCs combined with Matrigel into the mouse tibialis anterior muscle with volumetric muscle loss (VML) and observed a 73% reduction in the size of the defect and a 69% decrease in scar tissue. Noggin-treated DPSCs can benefit the Pax7+ SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite-like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite-like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.
A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in muscle regeneration due to the unknown induction mechanism. In this study, we treated human DPSCs with Noggin, a secreted antagonist of bone morphogenetic protein (BMP), and discovered that Noggin can effectively promote myotube formation. We also found that Noggin can accelerate the skeletal myogenic differentiation (MyoD) of DPSCs and promote the generation of Pax7[sup.+] satellite-like cells. Noggin increased the expression of myogenic markers and the transcriptional and translational abundance of satellite cell (SC) markers in DPSCs. Moreover, BMP4 inhibited Pax7 expression and activated p-Smad1/5/9, while Noggin eliminated BMP4-induced p-Smad1/5/9 in DPSCs. This finding suggests that Noggin antagonizes BMP by downregulating p-Smad and facilitates the MyoD of DPSCs. Then, we implanted Noggin-pretreated DPSCs combined with Matrigel into the mouse tibialis anterior muscle with volumetric muscle loss (VML) and observed a 73% reduction in the size of the defect and a 69% decrease in scar tissue. Noggin-treated DPSCs can benefit the Pax7[sup.+] SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite-like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite-like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.
A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in muscle regeneration due to the unknown induction mechanism. In this study, we treated human DPSCs with Noggin, a secreted antagonist of bone morphogenetic protein (BMP), and discovered that Noggin can effectively promote myotube formation. We also found that Noggin can accelerate the skeletal myogenic differentiation (MyoD) of DPSCs and promote the generation of Pax7 satellite-like cells. Noggin increased the expression of myogenic markers and the transcriptional and translational abundance of satellite cell (SC) markers in DPSCs. Moreover, BMP4 inhibited Pax7 expression and activated p-Smad1/5/9, while Noggin eliminated BMP4-induced p-Smad1/5/9 in DPSCs. This finding suggests that Noggin antagonizes BMP by downregulating p-Smad and facilitates the MyoD of DPSCs. Then, we implanted Noggin-pretreated DPSCs combined with Matrigel into the mouse tibialis anterior muscle with volumetric muscle loss (VML) and observed a 73% reduction in the size of the defect and a 69% decrease in scar tissue. Noggin-treated DPSCs can benefit the Pax7 SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite-like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite-like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.
A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in muscle regeneration due to the unknown induction mechanism. In this study, we treated human DPSCs with Noggin, a secreted antagonist of bone morphogenetic protein (BMP), and discovered that Noggin can effectively promote myotube formation. We also found that Noggin can accelerate the skeletal myogenic differentiation (MyoD) of DPSCs and promote the generation of Pax7+ satellite-like cells. Noggin increased the expression of myogenic markers and the transcriptional and translational abundance of satellite cell (SC) markers in DPSCs. Moreover, BMP4 inhibited Pax7 expression and activated p-Smad1/5/9, while Noggin eliminated BMP4-induced p-Smad1/5/9 in DPSCs. This finding suggests that Noggin antagonizes BMP by downregulating p-Smad and facilitates the MyoD of DPSCs. Then, we implanted Noggin-pretreated DPSCs combined with Matrigel into the mouse tibialis anterior muscle with volumetric muscle loss (VML) and observed a 73% reduction in the size of the defect and a 69% decrease in scar tissue. Noggin-treated DPSCs can benefit the Pax7+ SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite-like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite-like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myogenic induction efficiency of human DPSCs hinders their use in muscle regeneration due to the unknown induction mechanism. In this study, we treated human DPSCs with Noggin, a secreted antagonist of bone morphogenetic protein (BMP), and discovered that Noggin can effectively promote myotube formation. We also found that Noggin can accelerate the skeletal myogenic differentiation (MyoD) of DPSCs and promote the generation of Pax7+ satellite-like cells. Noggin increased the expression of myogenic markers and the transcriptional and translational abundance of satellite cell (SC) markers in DPSCs. Moreover, BMP4 inhibited Pax7 expression and activated p-Smad1/5/9, while Noggin eliminated BMP4-induced p-Smad1/5/9 in DPSCs. This finding suggests that Noggin antagonizes BMP by downregulating p-Smad and facilitates the MyoD of DPSCs. Then, we implanted Noggin-pretreated DPSCs combined with Matrigel into the mouse tibialis anterior muscle with volumetric muscle loss (VML) and observed a 73% reduction in the size of the defect and a 69% decrease in scar tissue. Noggin-treated DPSCs can benefit the Pax7+ SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite-like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite-like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.
Audience Academic
Author Zhang, Wei-Hua
Yu, Li-Ming
He, Hua
Zhang, Meng-Han
Huang, Wei
Chen, Mei-Hua
Deng, Jia-Jia
Li, Jiao
Han, Xin-Xin
Liu, Yue-Hua
Sun, Bing-Jing
AuthorAffiliation 3 Department of Neurosurgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, China
1 Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China
2 School of Stomatology Affiliated to Medical College, Zhejiang University, Hangzhou, China
AuthorAffiliation_xml – name: 2 School of Stomatology Affiliated to Medical College, Zhejiang University, Hangzhou, China
– name: 3 Department of Neurosurgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, China
– name: 1 Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China
Author_xml – sequence: 1
  givenname: Meng-Han
  orcidid: 0000-0002-3439-9465
  surname: Zhang
  fullname: Zhang, Meng-Han
– sequence: 2
  givenname: Li-Ming
  orcidid: 0000-0001-6737-0207
  surname: Yu
  fullname: Yu, Li-Ming
– sequence: 3
  givenname: Wei-Hua
  orcidid: 0000-0003-3520-9819
  surname: Zhang
  fullname: Zhang, Wei-Hua
– sequence: 4
  givenname: Jia-Jia
  orcidid: 0000-0002-2854-7206
  surname: Deng
  fullname: Deng, Jia-Jia
– sequence: 5
  givenname: Bing-Jing
  orcidid: 0009-0002-0258-0646
  surname: Sun
  fullname: Sun, Bing-Jing
– sequence: 6
  givenname: Mei-Hua
  orcidid: 0000-0002-0488-9391
  surname: Chen
  fullname: Chen, Mei-Hua
– sequence: 7
  givenname: Wei
  orcidid: 0000-0002-8964-3955
  surname: Huang
  fullname: Huang, Wei
– sequence: 8
  givenname: Jiao
  orcidid: 0009-0002-9363-1911
  surname: Li
  fullname: Li, Jiao
– sequence: 9
  givenname: Hua
  orcidid: 0000-0001-9160-3859
  surname: He
  fullname: He, Hua
– sequence: 10
  givenname: Xin-Xin
  orcidid: 0000-0002-7870-250X
  surname: Han
  fullname: Han, Xin-Xin
– sequence: 11
  givenname: Yue-Hua
  orcidid: 0000-0003-3033-8873
  surname: Liu
  fullname: Liu, Yue-Hua
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39758702$$D View this record in MEDLINE/PubMed
BookMark eNptkl1vFCEYhSemxtbaK-8NiYkxMdvyMQxwZZr1o02qNlajXhEG3pllnYF1mDHx38t217VrhAsIPO8BDudhcRBigKJ4TPApIZyfJevPqCSUKXyvOCKVFDNVCXmwm1dfD4uTlJY4twyVmD4oDpkSXApMj4pv72Pb-oDmsa99AIe--HGBLqbeBPQKwmg6dD11K3QzQo_m0HUJjRFdD7GPI6Cb79DBmnk3JdsB-ggtBBjM6GN4VNxvTJfgZDseF5_fvP40v5hdfXh7OT-_mtmyouOM10oIqBkVNWPKScdZSU1TqpI1THFLK4aFIY3BtnRgG8m4cuCA15RS7Ag7Li43ui6apV4NvjfDLx2N17cLcWi1GUafr6cFSEwEaUpnbWmVMaaSNacNxxQkUJG1Xm60VlPdg7PZgMF0e6L7O8EvdBt_akIqlRvOCs-3CkP8MUEade-Tzb6ZAHFKmhFOpFBMsYw-_QddxmkI2atbKn-fKtVfqjX5BT40MR9s16L6XFLKBGdMZur0P1TuDnpvc2Qan9f3Cp7dKViA6cZFit20_rm0Dz65a8nOiz8RysCLDWCHmNIAzQ4hWK8zqnNG9Taj7DfCTdW4
Cites_doi 10.1242/bio.014068
10.1155/2022/9783430
10.1093/rb/rbaa052
10.1016/j.celrep.2017.01.040
10.1155/2021/8884283
10.1016/j.semcdb.2017.11.005
10.1242/dev.157339
10.1038/nbt.3297
10.1186/1479-5876-6-35
10.1242/dev.00688
10.1242/dev.124.20.3955
10.1096/fj.201800574RR
10.1101/gad.13.24.3231
10.1016/S2213-8587(14)70034-8
10.1007/s12015-011-9235-9
10.1186/s13287-015-0141-y
10.1242/dev.124.22.4605
10.1016/S0092-8674(02)01078-4
10.3390/cells10112899
10.1016/j.archoralbio.2010.03.003
10.1016/j.biochi.2019.04.003
10.1007/978-1-4939-3810-0_2
10.1167/iovs.10-6878
10.1016/j.dental.2014.12.015
10.1038/srep31949
10.12659/MSM.919501
10.1002/jor.22730
10.1007/s12015-021-10162-6
10.1152/physrev.00043.2011
10.1016/j.tcb.2014.12.004
10.1016/j.expneurol.2019.113086
10.1242/dev.144089
10.1096/fj.08-123661
10.1016/S0002-9440(10)62484-4
10.1152/ajpcell.00388.2009
10.1089/ten.2006.12.2813
10.21203/rs.3.rs-861400/v1
ContentType Journal Article
Copyright Copyright © 2024 Meng-Han Zhang et al.
COPYRIGHT 2024 John Wiley & Sons, Inc.
Copyright © 2024 Meng-Han Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
Copyright © 2024 Meng-Han Zhang et al. 2024
Copyright_xml – notice: Copyright © 2024 Meng-Han Zhang et al.
– notice: COPYRIGHT 2024 John Wiley & Sons, Inc.
– notice: Copyright © 2024 Meng-Han Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
– notice: Copyright © 2024 Meng-Han Zhang et al. 2024
DBID AAYXX
CITATION
NPM
3V.
7QO
7T5
7TK
7TM
7X7
7XB
8AO
8FD
8FI
8FJ
8FK
8G5
ABUWG
AEUYN
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
K9.
M0S
M2O
MBDVC
P64
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
Q9U
RC3
7X8
5PM
DOA
DOI 10.1155/sci/2812390
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
ProQuest Health & Medical Collection (NC LIVE)
ProQuest Central (purchase pre-March 2016)
ProQuest Pharma Collection
Technology Research Database
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Research Library
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest One Sustainability
Genetics Abstracts
Health Research Premium Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Central (New)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Immunology Abstracts
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database
CrossRef


PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Open Access Full Text
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1687-9678
Editor Gianpaolo Papaccio
Editor_xml – fullname: Gianpaolo Papaccio
ExternalDocumentID oai_doaj_org_article_7e80171f4dcc4c9aaa68b52f502e8e27
PMC11699990
A822375338
39758702
10_1155_sci_2812390
Genre Journal Article
GeographicLocations United States
China
Beijing China
United States--US
GeographicLocations_xml – name: China
– name: United States
– name: Beijing China
– name: United States--US
GrantInformation_xml – fundername: National Natural Science Foundation of China
  grantid: 81771109; 81901031; 82071153
– fundername: Natural Science Foundation of Shanghai Municipality
  grantid: 19ZR1445400
– fundername: Zhejiang Province Traditional Chinese Medicine Science and Technology Project
  grantid: 2025ZR047
GroupedDBID ---
0R~
188
24P
2UF
53G
5VS
7X7
8AO
8FI
8FJ
8G5
AAFWJ
AAJEY
AAYXX
ABDBF
ABUWG
ACCMX
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
AINHJ
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
CCPVR
CITATION
CNMHZ
DIK
DWQXO
E3Z
EBD
EBS
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
H13
HMCUK
HYE
IAO
IEA
IHR
IHW
IPNFZ
ITC
KQ8
M2O
M48
M~E
O5R
O5S
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
RIG
RNS
RPM
TUS
TUXDW
UKHRP
UZ3
NPM
PMFND
3V.
7QO
7T5
7TK
7TM
7XB
8FD
8FK
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
FR3
H94
K9.
MBDVC
P64
PKEHL
PQEST
PQUKI
PRINS
PUEGO
Q9U
RC3
7X8
5PM
ID FETCH-LOGICAL-c462t-5b977eb327b339d8d5342af4943f395c26307a1fa0c4decf8359dede5b2220d13
IEDL.DBID M48
ISSN 1687-966X
1687-9678
IngestDate Wed Aug 27 01:30:27 EDT 2025
Thu Aug 21 18:35:04 EDT 2025
Fri Jul 11 04:52:38 EDT 2025
Sat Aug 23 14:53:45 EDT 2025
Sun Jun 15 06:15:21 EDT 2025
Tue Jun 10 20:53:49 EDT 2025
Thu May 22 21:23:31 EDT 2025
Thu Apr 03 07:00:06 EDT 2025
Tue Jul 01 03:23:43 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Copyright © 2024 Meng-Han Zhang et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c462t-5b977eb327b339d8d5342af4943f395c26307a1fa0c4decf8359dede5b2220d13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Academic Editor: Gianpaolo Papaccio
ORCID 0000-0002-3439-9465
0000-0003-3520-9819
0009-0002-0258-0646
0000-0002-7870-250X
0000-0003-3033-8873
0000-0002-8964-3955
0000-0002-0488-9391
0009-0002-9363-1911
0000-0001-6737-0207
0000-0002-2854-7206
0000-0001-9160-3859
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1155/sci/2812390
PMID 39758702
PQID 3151687949
PQPubID 2037505
ParticipantIDs doaj_primary_oai_doaj_org_article_7e80171f4dcc4c9aaa68b52f502e8e27
pubmedcentral_primary_oai_pubmedcentral_nih_gov_11699990
proquest_miscellaneous_3151879393
proquest_journals_3151687949
gale_infotracmisc_A822375338
gale_infotracacademiconefile_A822375338
gale_healthsolutions_A822375338
pubmed_primary_39758702
crossref_primary_10_1155_sci_2812390
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-01-01
PublicationDateYYYYMMDD 2024-01-01
PublicationDate_xml – month: 01
  year: 2024
  text: 2024-01-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle Stem cells international
PublicationTitleAlternate Stem Cells Int
PublicationYear 2024
Publisher John Wiley & Sons, Inc
Wiley
Publisher_xml – name: John Wiley & Sons, Inc
– name: Wiley
References Nakatsuka R. (e_1_2_15_27_2) 2020; 55
e_1_2_15_18_2
e_1_2_15_19_2
Zhang W. (e_1_2_15_26_2) 2020; 45
e_1_2_15_20_2
Darabi R. (e_1_2_15_35_2) 2012; 10
e_1_2_15_2_2
e_1_2_15_1_2
e_1_2_15_28_2
e_1_2_15_23_2
e_1_2_15_24_2
e_1_2_15_21_2
e_1_2_15_22_2
e_1_2_15_9_2
e_1_2_15_8_2
e_1_2_15_7_2
e_1_2_15_6_2
Pollot B. E. (e_1_2_15_4_2) 2016
e_1_2_15_5_2
e_1_2_15_29_2
e_1_2_15_3_2
Costamagna D. (e_1_2_15_25_2) 2016; 6
e_1_2_15_31_2
e_1_2_15_30_2
e_1_2_15_16_2
e_1_2_15_39_2
e_1_2_15_17_2
e_1_2_15_38_2
e_1_2_15_14_2
e_1_2_15_37_2
e_1_2_15_15_2
e_1_2_15_36_2
e_1_2_15_12_2
e_1_2_15_13_2
e_1_2_15_34_2
e_1_2_15_10_2
e_1_2_15_33_2
e_1_2_15_11_2
e_1_2_15_32_2
References_xml – ident: e_1_2_15_33_2
  doi: 10.1242/bio.014068
– ident: e_1_2_15_17_2
  doi: 10.1155/2022/9783430
– ident: e_1_2_15_12_2
  doi: 10.1093/rb/rbaa052
– ident: e_1_2_15_18_2
  doi: 10.1016/j.celrep.2017.01.040
– ident: e_1_2_15_15_2
  doi: 10.1155/2021/8884283
– ident: e_1_2_15_16_2
  doi: 10.1016/j.semcdb.2017.11.005
– ident: e_1_2_15_19_2
  doi: 10.1242/dev.157339
– ident: e_1_2_15_34_2
  doi: 10.1038/nbt.3297
– ident: e_1_2_15_13_2
  doi: 10.1186/1479-5876-6-35
– ident: e_1_2_15_24_2
  doi: 10.1242/dev.00688
– volume: 10
  start-page: 610
  year: 2012
  ident: e_1_2_15_35_2
  article-title: Human ES- and iPS-Derived Myogenic Progenitors Restore Dystrophin and Improve Contractility Upon Transplantation in Dystrophic mice
  publication-title: Stem Cell
– ident: e_1_2_15_20_2
  doi: 10.1242/dev.124.20.3955
– ident: e_1_2_15_29_2
  doi: 10.1096/fj.201800574RR
– ident: e_1_2_15_28_2
  doi: 10.1101/gad.13.24.3231
– ident: e_1_2_15_2_2
  doi: 10.1016/S2213-8587(14)70034-8
– ident: e_1_2_15_10_2
  doi: 10.1007/s12015-011-9235-9
– ident: e_1_2_15_14_2
  doi: 10.1186/s13287-015-0141-y
– ident: e_1_2_15_21_2
  doi: 10.1242/dev.124.22.4605
– ident: e_1_2_15_37_2
  doi: 10.1016/S0092-8674(02)01078-4
– ident: e_1_2_15_7_2
  doi: 10.3390/cells10112899
– volume: 45
  start-page: 1501
  year: 2020
  ident: e_1_2_15_26_2
  article-title: The Secretome of Human Dental Pulp Stem Cells Protects Myoblasts From Hypoxia-Induced Injury via the Wnt/Beta-Catenin Pathway
  publication-title: International Journal of Molecular Medicine
– volume: 55
  start-page: 350
  year: 2020
  ident: e_1_2_15_27_2
  article-title: 5-Aza-2′-Deoxycytidine Treatment Induces Skeletal Myogenic Differentiation of Mouse Dental Pulp Stem Cells
  publication-title: Archives of Oral Biology
  doi: 10.1016/j.archoralbio.2010.03.003
– ident: e_1_2_15_30_2
  doi: 10.1016/j.biochi.2019.04.003
– start-page: 19
  volume-title: Skeletal Muscle Regeneration in the Mouse
  year: 2016
  ident: e_1_2_15_4_2
  doi: 10.1007/978-1-4939-3810-0_2
– ident: e_1_2_15_32_2
  doi: 10.1167/iovs.10-6878
– ident: e_1_2_15_8_2
  doi: 10.1016/j.dental.2014.12.015
– volume: 6
  year: 2016
  ident: e_1_2_15_25_2
  article-title: Noggin Inactivation Affects the Number and Differentiation Potential of Muscle Progenitor Cells in Vivo
  publication-title: Scientific Reports
  doi: 10.1038/srep31949
– ident: e_1_2_15_3_2
  doi: 10.12659/MSM.919501
– ident: e_1_2_15_5_2
  doi: 10.1002/jor.22730
– ident: e_1_2_15_9_2
  doi: 10.1007/s12015-021-10162-6
– ident: e_1_2_15_1_2
  doi: 10.1152/physrev.00043.2011
– ident: e_1_2_15_22_2
  doi: 10.1016/j.tcb.2014.12.004
– ident: e_1_2_15_6_2
  doi: 10.1016/j.expneurol.2019.113086
– ident: e_1_2_15_23_2
  doi: 10.1242/dev.144089
– ident: e_1_2_15_36_2
  doi: 10.1096/fj.08-123661
– ident: e_1_2_15_38_2
  doi: 10.1016/S0002-9440(10)62484-4
– ident: e_1_2_15_31_2
  doi: 10.1152/ajpcell.00388.2009
– ident: e_1_2_15_11_2
  doi: 10.1089/ten.2006.12.2813
– ident: e_1_2_15_39_2
  doi: 10.21203/rs.3.rs-861400/v1
SSID ssj0000390402
Score 2.3121345
Snippet A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 2812390
SubjectTerms Antibodies
Biomarkers
Bone growth
Bone morphogenetic proteins
Cell cycle
Cell differentiation
Dental pulp
Muscles
Musculoskeletal system
MyoD protein
Myogenesis
Myotubes
Neuromuscular diseases
Noggin protein
Regeneration
Satellite cells
Skeletal muscle
Smad protein
Stem cell transplantation
Stem cells
Tibialis anterior muscle
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9UwDI_QJCQuiG8KA4I0iVO1l682OY7BNCFtmhgT4xTlw2UTj76J13fgv8dJuqdWHLhwbdyqsWP7Z8t2CNmLUbjOt01tPNO1ZNHXhqd0mE-X7ejo2pzKPjltji_kp0t1ObnqK9WElfHAhXH7Leg00qWTMQQZjHOu0V7xTi04aOC5jxx93iSYyjYYQ_lcupMb8tBnpi6ZfY7eTCTrO3FBeVL_3_Z44pDmxZIT73P0gNwfYSM9KL_7kNyB_hG5Wy6S_P2YfDtdpcwxRe3GSBci_Xo9XNGcoKcfcsMjPdssb-j5AD_pISyXazqs6FkuxQN6_gN9T6I52azx6_QzfM_DqJPMnpCLo49fDo_r8dKEOsiGD7XyiOgwQuatF8JEHZWQ3HXSSNEJowJvUKsd69wiyAihQwRmIkRQHpHCIjLxlOz0qx6eExpUbFHFgbPYSeGFB8DgI3rZMI84j1Vk75aP9qbMxrA5plDKIrvtyO6KvE883pKkgdb5AYrZjmK2_xJzRd4kCdnSHbpVS3uAAEdgyCV0Rd5liqSYKKjgxv4C3EsacTWj3J1RokKF-fLtKbCjQq-tQGTUaDRepiJvt8vpzVSk1sNqU2iQRBhRkWfl0Gw3jbBPoWnkFdGz4zTjynylv77K474ZaxDFm8WL_8HHl-QeR1hWkki7ZGf4tYFXCKsG_zpr0B-ENh-5
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Health & Medical Collection (NC LIVE)
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEF5BERIXRHka2rJIlThZtfdhe0-oFKoKqVVFqQinlffhtiLYoXEO_Htm1hsTC6nX7DiKZ-fxzWQehOw7x-vGlEWqTF6lIncmVQzTYQaX7VSuLkMq-_SsOLkUX2ZyFhNuy1hWubaJwVC7zmKO_ICDayoqkB71YfE7xa1R-O9qXKFxnzzA0WUo1eWsHHMsGQT0Yig7hEdxEOUstuiBF8W-mQMG_o2jPd5wSmF2__8WesNFTcsnN_zR8RPyOAJJejjc_Da559un5OGwWvLPM_LjrMNcMgV9h9jXO_r9pr-mIWVPP4UWSHq-mi_oRe9_0SM_ny9p39HzUJzn6cVP8EZIc7pawrfTr_4qjKfGW3xOLo8_fzs6SeMahdSKgvWpNIDxIGZmpeFcucpJLljdCCV4w5W0rAA9r_Omzqxw3jaAyZTzzksD2CFzOX9Bttqu9a8ItdKVoPSe5a4R3HDjPYQjzogiN4D88oTsr_moF8O0DB2iDCk1sFtHdifkI_J4JMER1-GD7vZKR43Rpa9wlk8jnLXCqrqui8pI1siM-cqzMiFv8Yb00C86Kqo-BMjDIQjjVULeBwpUVbgoW8eOA3gXHHo1odyZUIKK2enxWgp0VPGl_ieQCXk3HuOTWLbW-m410AAJVzwhLwehGV8agKAEY8kSUk3EacKV6Ul7cx0GgOd5AbheZa_v_l1vyCMGEGxIGO2Qrf525XcBQvVmL-jJX9DvGOg
  priority: 102
  providerName: ProQuest
Title Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration
URI https://www.ncbi.nlm.nih.gov/pubmed/39758702
https://www.proquest.com/docview/3151687949
https://www.proquest.com/docview/3151879393
https://pubmed.ncbi.nlm.nih.gov/PMC11699990
https://doaj.org/article/7e80171f4dcc4c9aaa68b52f502e8e27
Volume 2024
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEB71ISQuiHcNJSxSJU6GeB-294BQW1pVSImilohwWnkfbiuCXRJHov-e2bUT1cCBq3dsybPz7Xwz2pkBOLCWFaXO0ljqJI95YnUsqU-HaT9sJ7dFFlLZo3F6NuWfZ2K2BethnJ0Cl_8M7fw8qeli_u7Xz9uPCPgPAfBC-AKY9xQdFYbv27CLLinzowxGHc8PRzIu8fb-YYqgQoo_62r1_ni_551CE_-_j-o7vqp_j_KOYzp9CA86RkkOWxN4BFuuegz32hmTt0_g27j2SWWCwMcg2Fny9bq5IiF3Tz6FWkgyWc1vyEXjfpBjN58vSVOTSbil58jFd3RLXma0WuLXybm7DH2q_XY-henpyZfjs7ibpxAbntImFhrJHgbPNNOMSZtbwTgtSi45K5kUhqYI-CIpi6Hh1pkSyZm0zjqhkUQMbcKewU5VV24PiBE2Q_Q7mtiSM820cxiXWM3TRCMFTCI4WOtR3bRtM1QIN4RQqG7VqTuCI6_jjYjvdR0e1ItL1UFHZS73TX1Kbo3hRhZFkeZa0FIMqcsdzSJ47XdItYWjG8SqQ-Q-DKMxlkfwNkh4K8KNMkVXeoD_4rtf9ST3e5KINdNfXluBWpuqYkia0KoklxG82Sz7N_39tcrVq1YGRZhkETxvjWbz08gIBZ6aNIK8Z049rfRXquur0Ak8SVIk-HL44v_U_RLuU-RkbQZpH3aaxcq9Qk7V6AFsZ7NsALtHJ-PJ-SBkJgYBQ78Bsu4g3g
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NIQQviG8CgxlpiKdoie18-AGhsTF1bK0mtonuycQf2aZ1TVlTof1T_I2cnbQ0QuJtr_U1Ss5397s7--4ANoxhRamyNBQqzkMeGxUK6tJhyg3byU2R-VR2f5D2TvjXYTJcgd_zWhh3rXJuE72hNpV2OfJNhtCU5ig94tPkZ-imRrnT1fkIjUYs9u3NLwzZph_3dnB_31O6--V4uxe2UwVCzVNah4lClwdDSJopxoTJTcI4LUouOCuZSDRNUeyLuCwizY3VJboowlhjE4VQGpmY4XPvwF0E3sgFe9kwW-R0IiZQJ_wBK76qa3w5bEsCEbVdnc4mRTxlzv4vgaCfFfAvIixBYve65hL-7T6Ch63jSrYaSXsMK3b8BO41oyxvnsLpoHK5a4L2BWNta8j3i_qc-CMCsuNLLsnhbDQhR7W9Itt2NJqSuiKH_jKgJUeXiH6Opj-b4tPJN3vm22E7qXkGJ7fC4OewOq7G9iUQnZgMjYylsSk5U0xZi-GPUTyNFXqacQAbcz7KSdOdQ_qoJkkkslu27A7gs-PxgsS11PY_VNdnstVQmdnc9Q4qudGaa1EURZqrhJZJRG1uaRbAutsh2dSnLgyD3EIXi2HQx_IAPngKZxpwo3TRVjjgt7gmWx3KtQ4lqrTuLs-lQLYmZSr_KkAA7xbL7p_umtzYVrOGBkmYYAG8aIRm8dHoeCZonGkAeUecOlzprowvzn3D8ThOMY4Q0av_v9c63O8d9w_kwd5g_zU8oOj-NcmqNVitr2f2DbpvtXrrdYbAj9tW0j_W_FWJ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9NADLdGJxAviG8Cgx3SEE9Rk7vL1wNC27pqY6yqNia6pyP3kW1a15Q1Fdq_xl-H75KWRki87bXnRonP9s_2nW2ALa1ZXsgk9jMZpj4PtfQzatNh0g7bSXWeuFT20SDeP-VfRtFoDX4vamHstcqFTXSGWpfK5si7DKEpTlF6sm7RXIsY9vqfpz99O0HKnrQuxmnUInJobn9h-Db7dNDDvf5AaX_v2-6-30wY8BWPaeVHEt0fDCdpIhnLdKojxmle8IyzgmWRojGqQB4WeaC4NqpAdyXTRptIIqwGOmT43HuwntioqAPrO3uD4fEywxOwDDXEHbfii9s2mKOmQBAx3FbtdCmiK7NosAKJbnLAv_iwApDty5sraNh_DI8aN5Zs13L3BNbM5Cncrwdb3j6Ds0FpM9kErQ1G3kaT75fVBXEHBqTnCjDJcD6ekpPKXJNdMx7PSFWSobsaaMjJFWKhpTmaz_Dp5Nicu-bYVoaew-mdsPgFdCblxLwCoiKNnA4MDXXBmWTSGAyGtORxKNHvDD3YWvBRTOteHcLFOFEkkN2iYbcHO5bHSxLbYNv9UN6ci0ZfRWJS20mo4FoprrI8z-NURrSIAmpSQxMPNu0OibpadWkmxDY6XAxDQJZ68NFRWEOBG6Xypt4Bv8W23GpRbrQoUcFVe3khBaIxMDPxVx08eL9ctv-0l-YmppzXNEjCMubBy1polh-NbmiEppp6kLbEqcWV9srk8sK1Hw_DGKOKLHj9__fahAeooOLrweDwDTyk6AvWmasN6FQ3c_MWfblKvmuUhsCPu9bTP7A8WyQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Noggin+Combined+With+Human+Dental+Pulp+Stem+Cells+to+Promote+Skeletal+Muscle+Regeneration&rft.jtitle=Stem+cells+international&rft.au=Zhang%2C+Meng-Han&rft.au=Yu%2C+Li-Ming&rft.au=Zhang%2C+Wei-Hua&rft.au=Deng%2C+Jia-Jia&rft.date=2024-01-01&rft.issn=1687-966X&rft.eissn=1687-9678&rft.volume=2024&rft.issue=1&rft_id=info:doi/10.1155%2Fsci%2F2812390&rft.externalDBID=n%2Fa&rft.externalDocID=10_1155_sci_2812390
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1687-966X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1687-966X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1687-966X&client=summon