Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

• Published in: Frontiers in pharmacology Vol. 8; p. 816
• Main Authors: Parikh, Jaimit, Gurev, Viatcheslav, Rice, John J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.11.2017
• Subjects: cardiac modeling; classification and prediction; early afterdepolarization; machine-learning; Pharmacology; Torsades de Pointes; early afterdepolarization; machine-learning; classification and prediction; Torsades de Pointes; cardiac modeling

While pre-clinical Torsades de Pointes (TdP) risk classifiers had initially been based on drug-induced block of hERG potassium channels, it is now well established that improved risk prediction can be achieved by considering block of non-hERG ion channels. The current multi-channel TdP classifiers c...