IgM Repertoire Biodiversity is Reduced in HIV-1 Infection and Systemic Lupus Erythematosus

• Published in: Frontiers in immunology Vol. 4; p. 373
• Main Authors: Yin, Li, Hou, Wei, Liu, Li, Cai, Yunpeng, Wallet, Mark Andrew, Gardner, Brent Paul, Chang, Kaifen, Lowe, Amanda Catherine, Rodriguez, Carina Adriana, Sriaroon, Panida, Farmerie, William George, Sleasman, John William, Goodenow, Maureen Michels
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.01.2013
• Subjects: Biodiversity; HIV-1; IgM memory B cells; Immunology; pyrosequencing; somatic hypermutation; systemic lupus erythematosus; HIV-1; IgM memory B cells; systemic lupus erythematosus; biodiversity; somatic hypermutation; IgM antibody transcriptome repertoire; naïve B cells; pyrosequencing
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2013.00373

HIV-1 infection or systemic lupus erythematosus (SLE) disrupt B cell homeostasis, reduce memory B cells, and impair function of IgG and IgM antibodies. To determine how disturbances in B cell populations producing polyclonal antibodies relate to the IgM repertoire, the IgM transcriptome in health an...