Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors - Huang, Shih-Chung; Adhikari, Sharmila; Brownell, James E.; Calderwood, Emily F.; Chouitar, Jouhara; D'Amore, Natalie Roy; England, Dylan B.; Foley, Klaudia; Harrison, Sean J.; LeRoy, Patrick J.; Lok, David; Lublinsky, Anna; et al. (Bioorganic & medicinal chemistry, 2020)
Keywords: ATG7; ATG7 inhibitor; Autophagy; Autophagy - drug effects; Autophagy-Related Protein 7 - antagonists & inhibitors; Autophagy-Related Protein 7 - metabolism; Biochemistry & Molecular Biology; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Dose-Response Relationship, Drug; Drug Discovery; E1 enzyme; HEK293 Cells; Humans; Life Sciences & Biomedicine; Molecular Structure; Pharmacology & Pharmacy; Physical Sciences; Pyrazoles - chemical synthesis; Pyrazoles - chemistry; Pyrazoles - pharmacology; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Science & Technology; Structure-Activity Relationship; Sulfonic Acids - chemical synthesis; Sulfonic Acids - chemistry; Sulfonic Acids - pharmacology; ATG7 inhibitor; ATG7; Autophagy; E1 enzyme; UBIQUITIN