Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome

The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotect...

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Published inHeart and vessels Vol. 31; no. 4; pp. 535 - 544
Main Authors Kadowaki, Shinpei, Shishido, Tetsuro, Honda, Yuki, Narumi, Taro, Otaki, Yoichiro, Kinoshita, Daisuke, Nishiyama, Satoshi, Takahashi, Hiroki, Arimoto, Takanori, Miyamoto, Takuya, Watanabe, Tetsu, Kubota, Isao
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.04.2016
Springer Nature B.V
Subjects
Aged
Biomarkers - blood
Biomedical Engineering and Bioengineering
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Cardiac Surgery
Cardiology
Disease Progression
Echocardiography
Enzyme-Linked Immunosorbent Assay
Female
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Ventricles - diagnostic imaging
Humans
Incidence
Japan - epidemiology
Kaplan-Meier Estimate
Male
Medical prognosis
Medicine
Medicine & Public Health
Original Article
Prognosis
Radiography, Thoracic
Retrospective Studies
Risk Factors
ROC Curve
Survival Rate - trends
Vascular Surgery
Heart failure
Brain-derived neurotrophic factor
Prognosis
Risk stratification
Online AccessGet full text
ISSN0910-8327
1615-2573
1615-2573
DOI10.1007/s00380-015-0628-6

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Abstract The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4, P  < 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5, P  < 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan–Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622–5.301; P  = 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 ( P  < 0.001) and an integrated discrimination improvement of 0.101 ( P  < 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.
AbstractList The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4, P < 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5, P < 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan-Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels ([less than or equal to]12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622-5.301; P = 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 (P < 0.001) and an integrated discrimination improvement of 0.101 (P < 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.
The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4, P  < 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5, P  < 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan–Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622–5.301; P  = 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 ( P  < 0.001) and an integrated discrimination improvement of 0.101 ( P  < 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.
The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4, P < 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5, P < 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan-Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622-5.301; P = 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 (P < 0.001) and an integrated discrimination improvement of 0.101 (P < 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4, P < 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5, P < 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan-Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622-5.301; P = 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 (P < 0.001) and an integrated discrimination improvement of 0.101 (P < 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.
The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depression mechanisms and also in stress and anxiety. Because BDNF is reported about cardioprotective role, we elucidated whether BDNF is associated with cardiovascular events in patients with chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with CHF and 23 control subjects. The patients were followed to register cardiac events for a median of 426 days. BDNF was significantly lower in CHF patients than in control subjects (25.8 ± 8.4 vs 14.7 ± 8.4, P < 0.0001). Serum BDNF was also lower in patients with cardiac events than in event-free patients (16.1 ± 8.0 vs 12.5 ± 8.5, P < 0.0001). The cutoff value of BDNF was determined by performing receiver operating characteristic curve analysis. Kaplan-Meier analysis demonstrated that patients with low levels of BDNF experienced higher rates of cardiac events than those with high levels of BDNF. Multivariate Cox hazard analysis demonstrated that low BDNF levels (≤12.4 ng/mL) were an independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % confidence interval 1.622-5.301; P = 0.0004). Adding levels of BDNF to the model with BNP levels, age, and eGFR for the prediction of cardiac events yielded significant net reclassification improvement of 0.429 (P < 0.001) and an integrated discrimination improvement of 0.101 (P < 0.001). Low serum BDNF levels were found in patients with CHF, and these levels were found to be independently associated with an increased risk of cardiac events.
Author Narumi, Taro
Shishido, Tetsuro
Watanabe, Tetsu
Honda, Yuki
Kadowaki, Shinpei
Miyamoto, Takuya
Kinoshita, Daisuke
Kubota, Isao
Takahashi, Hiroki
Arimoto, Takanori
Otaki, Yoichiro
Nishiyama, Satoshi
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  givenname: Tetsuro
  surname: Shishido
  fullname: Shishido, Tetsuro
  email: tshishid@med.id.yamagata-u.ac.jp
  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
– sequence: 3
  givenname: Yuki
  surname: Honda
  fullname: Honda, Yuki
  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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  givenname: Taro
  surname: Narumi
  fullname: Narumi, Taro
  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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  fullname: Otaki, Yoichiro
  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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  surname: Kinoshita
  fullname: Kinoshita, Daisuke
  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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  surname: Arimoto
  fullname: Arimoto, Takanori
  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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  givenname: Takuya
  surname: Miyamoto
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  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
– sequence: 12
  givenname: Isao
  surname: Kubota
  fullname: Kubota, Isao
  organization: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25616498$$D View this record in MEDLINE/PubMed
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Thu Apr 03 06:56:30 EDT 2025
Tue Jul 01 00:51:02 EDT 2025
Thu Apr 24 23:05:29 EDT 2025
Fri Feb 21 02:27:24 EST 2025
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Keywords Heart failure
Brain-derived neurotrophic factor
Prognosis
Risk stratification
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Snippet The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the...
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SubjectTerms Aged
Biomarkers - blood
Biomedical Engineering and Bioengineering
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Cardiac Surgery
Cardiology
Disease Progression
Echocardiography
Enzyme-Linked Immunosorbent Assay
Female
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Ventricles - diagnostic imaging
Humans
Incidence
Japan - epidemiology
Kaplan-Meier Estimate
Male
Medical prognosis
Medicine
Medicine & Public Health
Original Article
Prognosis
Radiography, Thoracic
Retrospective Studies
Risk Factors
ROC Curve
Survival Rate - trends
Vascular Surgery
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Title Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome
URI https://link.springer.com/article/10.1007/s00380-015-0628-6
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