Impact of Gonadotropin-Releasing Hormone Agonist Pre-treatment on the Cumulative Live Birth Rate in Infertile Women With Adenomyosis Treated With IVF/ICSI: A Retrospective Cohort Study

• Published in: Frontiers in endocrinology (Lausanne) Vol. 11; p. 318
• Main Authors: Chen, Minghui, Luo, Lu, Wang, Qiong, Gao, Jun, Chen, Yuqing, Zhang, Yingying, Zhou, Canquan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.05.2020
• Subjects: adenomyosis; Adenomyosis - complications; Embryo Transfer; Endocrinology; Female; Fertilization in Vitro - methods; GnRH agonist; Gonadotropin-Releasing Hormone - agonists; Humans; in vitro fertilization; Infertility, Female - complications; Live Birth; live birth rate; ovarian stimulation; Pregnancy; Pregnancy Rate; Retrospective Studies; Treatment Outcome; in vitro fertilization; GnRH agonist; adenomyosis; live birth rate; ovarian stimulation

Although pre-treatment with a GnRH agonist can reduce the size of adenomyosis lesions, the supra-physiological hormone level induced by controlled ovarian hyperstimulation (COH) may negate the usefulness of the GnRH agonist in patients with adenomyosis lesions, leading to continued poor outcomes in...