Catalytic asymmetric synthesis of tetrahydrocarbazoles

• Published in: Chemical communications (Cambridge, England) Vol. 55; no. 44; pp. 6151 - 6164
• Main Authors: Tan, Fen, Cheng, Hong-Gang
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 28.05.2019
• Subjects: Alkaloids; Alkylation; Asymmetry; bioactive properties; Carbazoles - chemical synthesis; Carbazoles - chemistry; Catalysis; catalytic activity; chemical reactions; Chemical synthesis; Cycloaddition Reaction; drugs; indole alkaloids; Indoles - chemistry; Lewis Acids - chemistry; Molecular Structure; Reaction mechanisms; Stereoisomerism; stereoselective synthesis

Chiral tetrahydrocarbazoles (THCs) are prevalent in numerous natural indole alkaloids as well as synthetic pharmaceuticals, and exhibit a broad spectrum of bioactivities. As such, the development of efficient synthetic methodologies for the synthesis of chiral THCs is of substantial interest. The ad...