Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease

• Published in: Vascular medicine (London, England) Vol. 25; no. 5; pp. 411 - 418
• Main Authors: Duscha, Brian D, Kraus, William E, Jones, William S, Robbins, Jennifer L, Piner, Lucy W, Huffman, Kim M, Allen, Jason D, Annex, Brian H
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2020; Sage Publications Ltd
• Subjects: Aged; Anaerobic Threshold; Blood flow; Capillaries - physiopathology; Cardiovascular diseases; Case-Control Studies; Cross-Sectional Studies; Density; Endothelial cells; Exercise Tolerance; Female; Gastrocnemius muscle; Humans; Immunofluorescence; Intermittent Claudication - metabolism; Intermittent Claudication - physiopathology; Intolerance; Male; Microvascular Density; Middle Aged; Muscle, Skeletal - blood supply; Muscles; Musculoskeletal system; Nitric oxide; Oxidative metabolism; Peripheral Arterial Disease - metabolism; Peripheral Arterial Disease - physiopathology; Regional Blood Flow; Signs and symptoms; Skeletal muscle; Treadmills; Vanadium oxides; Vascular diseases; exercise; capillary density; angiogenesis; anaerobic threshold; peripheral artery disease (PAD)
• ISSN: 1358-863X; 1477-0377; 1477-0377
• DOI: 10.1177/1358863X20945794

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the h...