Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection

• Published in: Frontiers in immunology Vol. 11; p. 1011
• Main Authors: Perruzza, Lisa, Jaconi, Stefano, Lombardo, Gloria, Pinna, Debora, Strati, Francesco, Morone, Diego, Seehusen, Frauke, Hu, Yue, Bajoria, Sakshi, Xiong, Jian, Kumru, Ozan Selahattin, Joshi, Sangeeta Bagai, Volkin, David Bernard, Piantanida, Renato, Benigni, Fabio, Grassi, Fabio, Corti, Davide, Pizzuto, Matteo Samuele
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.06.2020
• Subjects: Animals; Antibodies, Bacterial - metabolism; Antibodies, Monoclonal - metabolism; Bacterial Proteins - immunology; Bacterial Vaccines - immunology; Campylobacter; Campylobacter - physiology; Campylobacter Infections - immunology; Disease Models, Animal; Disease Resistance; Female; flagellar-capping protein; FliD; Gastroenteritis - immunology; Humans; Immunoglobulin A - metabolism; Immunology; Immunotherapy - methods; Intestinal Mucosa - immunology; Mice; Mice, Inbred C57BL; monoclonal antibodies; Neutrophils - immunology; prophylaxis; secretory IgA; FliD; flagellar-capping protein; prophylaxis; secretory IgA; Campylobacter; monoclonal antibodies

infection is one of the most common causes of bacterial gastroenteritis worldwide and a major global health threat due to the rapid development of antibiotic resistance. Currently, there are no vaccines approved to prevent campylobacteriosis, and rehydration is the main form of therapy. Secretory im...