Pediatric Fibrinogen PART I—Pitfalls in Fibrinogen Evaluation and Use of Fibrinogen Replacement Products in Children
Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric surgery. Yet, the optimal measurement of fibrin...
Saved in:
| Published in | Frontiers in pediatrics Vol. 9; p. 617500 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
21.04.2021
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2296-2360 2296-2360 |
| DOI | 10.3389/fped.2021.617500 |
Cover
Loading…
| Abstract | Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric surgery. Yet, the optimal measurement of fibrinogen levels is subject to debate, as is the critical threshold for intervention. Fibrinogen replacement may be provided by cryoprecipitate and fibrinogen concentrate. Whilst both products contain fibrinogen, they are not equivalent, each has its own advantages and disadvantages, especially for pediatric use. Unfortunately, medical literature to support fibrinogen replacement in children is limited. In this article we review the current diagnostic tools to measure fibrinogen, with respect to their use in the pediatric critical care setting. Secondly, we evaluate the different fibrinogen replacement therapies, focusing on cryoprecipitate and fibrinogen concentrate and examine their individual product characteristics, associated risks and benefits, different dosing strategies and specific pitfalls for use in children. We summarize by highlighting current knowledge gaps and areas for future research. |
|---|---|
| AbstractList | Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric surgery. Yet, the optimal measurement of fibrinogen levels is subject to debate, as is the critical threshold for intervention. Fibrinogen replacement may be provided by cryoprecipitate and fibrinogen concentrate. Whilst both products contain fibrinogen, they are not equivalent, each has its own advantages and disadvantages, especially for pediatric use. Unfortunately, medical literature to support fibrinogen replacement in children is limited. In this article we review the current diagnostic tools to measure fibrinogen, with respect to their use in the pediatric critical care setting. Secondly, we evaluate the different fibrinogen replacement therapies, focusing on cryoprecipitate and fibrinogen concentrate and examine their individual product characteristics, associated risks and benefits, different dosing strategies and specific pitfalls for use in children. We summarize by highlighting current knowledge gaps and areas for future research. Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric surgery. Yet, the optimal measurement of fibrinogen levels is subject to debate, as is the critical threshold for intervention. Fibrinogen replacement may be provided by cryoprecipitate and fibrinogen concentrate. Whilst both products contain fibrinogen, they are not equivalent, each has its own advantages and disadvantages, especially for pediatric use. Unfortunately, medical literature to support fibrinogen replacement in children is limited. In this article we review the current diagnostic tools to measure fibrinogen, with respect to their use in the pediatric critical care setting. Secondly, we evaluate the different fibrinogen replacement therapies, focusing on cryoprecipitate and fibrinogen concentrate and examine their individual product characteristics, associated risks and benefits, different dosing strategies and specific pitfalls for use in children. We summarize by highlighting current knowledge gaps and areas for future research.Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric surgery. Yet, the optimal measurement of fibrinogen levels is subject to debate, as is the critical threshold for intervention. Fibrinogen replacement may be provided by cryoprecipitate and fibrinogen concentrate. Whilst both products contain fibrinogen, they are not equivalent, each has its own advantages and disadvantages, especially for pediatric use. Unfortunately, medical literature to support fibrinogen replacement in children is limited. In this article we review the current diagnostic tools to measure fibrinogen, with respect to their use in the pediatric critical care setting. Secondly, we evaluate the different fibrinogen replacement therapies, focusing on cryoprecipitate and fibrinogen concentrate and examine their individual product characteristics, associated risks and benefits, different dosing strategies and specific pitfalls for use in children. We summarize by highlighting current knowledge gaps and areas for future research. |
| Author | Crighton, Gemma Louise Huisman, Elise J. |
| AuthorAffiliation | 3 Department of Transfusion Medicine, Sanquin Blood Supply , Amsterdam , Netherlands 1 Department of Hematology, Erasmus Medical Center (MC)—Sophia Children's Hospital , Rotterdam , Netherlands 4 Department of Hematology, Royal Children's Hospital , Melbourne, VIC , Australia 2 Department of Clinical Chemistry and Blood Transfusion, Erasmus Medical Center (MC) , Rotterdam , Netherlands |
| AuthorAffiliation_xml | – name: 3 Department of Transfusion Medicine, Sanquin Blood Supply , Amsterdam , Netherlands – name: 2 Department of Clinical Chemistry and Blood Transfusion, Erasmus Medical Center (MC) , Rotterdam , Netherlands – name: 1 Department of Hematology, Erasmus Medical Center (MC)—Sophia Children's Hospital , Rotterdam , Netherlands – name: 4 Department of Hematology, Royal Children's Hospital , Melbourne, VIC , Australia |
| Author_xml | – sequence: 1 givenname: Elise J. surname: Huisman fullname: Huisman, Elise J. – sequence: 2 givenname: Gemma Louise surname: Crighton fullname: Crighton, Gemma Louise |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33968842$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks9uGyEQxlGVKkmT3Huq9tiLXf7ssuylUmQlraVItaLkjFgYHCIMLuxa6q0PkSfMkxTbaeRUKgdAzDe_Aeb7gI5CDIDQR4KnjInui12DmVJMyZSTtsH4HTqltOMTyjg-OtifoIucH3EZXYsb0hyjE8Y6LkRNT9FmAcapITldXbs-uRCXEKrF5e1dNX_-_bRwg1Xe58qFw_jVRvlRDS6GSgVT3Weooj0U3MLaKw0rCEO1SNGMetgxZg_OmwThHL0v3AwXL-sZur--upt9n9z8-DafXd5MdM3pMGmwUAIaRgg2PWAFFBMCrGe4JYLZvqct5owLTBirdQ-NsX1rmBW4L3PXsjM033NNVI9yndxKpV8yKid3BzEtpUqD0x5kzXnX8pYRC6SmmqgOBCgF1hLdMSoK6-uetR77FRhd3paUfwN9GwnuQS7jRory8aQhBfD5BZDizxHyIFcua_BeBYhjlrShtWhpaVGRfjqs9Vrkb-OKAO8FOsWcE9hXCcFyaw-5tYfc2kPu7VFS-D8p2g27JpbbOv__xD8-18Eh |
| CitedBy_id | crossref_primary_10_1111_trf_17340 crossref_primary_10_1016_j_wneu_2023_09_057 crossref_primary_10_1097_PCC_0000000000003492 |
| Cites_doi | 10.1111/j.1538-7836.2012.04905.x 10.1093/bja/aeq161 10.1097/ALN.0b013e31817885b7 10.1111/j.1365-3148.2010.01056.x 10.1258/0004563042466884 10.1160/TH14-06-0514 10.1111/trf.16076 10.1111/trf.14985 10.3390/jcm9082456 10.7205/MILMED-D-15-00166 10.1111/vox.12417 10.1111/ijlh.13043 10.1111/trf.14359 10.1111/voxs.12376 10.1046/j.1365-2141.2003.04256.x 10.1111/trf.12827 10.1111/trf.12479 10.1093/bja/aer003 10.1186/1471-2431-6-3 10.1213/01.ane.0000287645.26763.be 10.1111/trf.15157 10.1002/ajh.23599 10.1016/j.jpedsurg.2013.11.050 10.1097/EJA.0000000000000043 10.3390/children7120259 10.1080/00365513.2018.1437645 10.1111/pan.13574 10.1186/s13613-018-0457-8 10.1097/00000542-200509000-00031 10.1213/00000539-199508000-00026 10.23736/S0375-9393.16.11375-6 10.1155/2020/9153620 10.1111/j.1365-2141.2008.07267.x 10.1111/j.1749-6632.2001.tb03491.x 10.1111/trf.12431 10.1016/j.jtcvs.2014.04.029 10.1007/978-1-62703-339-8_14 10.1515/cclm-2016-0931 10.5578/ced.68125 10.1111/trf.12322 10.1177/0267659119854246 10.2450/2015.0113-15 10.1213/ANE.0000000000000448 10.1093/bja/aeq058 10.1161/01.STR.0000017219.83330.FF 10.1097/ALN.0000000000001058 10.1111/trf.12918 10.1007/s00277-017-3028-4 10.1111/bjh.13580 10.1186/s13052-019-0709-8 10.1016/j.transci.2018.10.013 10.1111/j.1460-9592.2004.01549.x 10.1093/bja/aeq258 10.1111/j.1538-7836.2007.02481.x 10.1111/hae.12042 10.1093/bja/aeu158 10.1111/bjh.15167 10.1111/bjh.14233 10.2450/2011.0015-11 10.1160/TH05-01-0047 10.1111/tme.12502 10.1182/blood-2018-07-818211 10.1111/bjh.13058 10.1213/ANE.0000000000004384 10.1111/trf.14259 10.1182/blood.V88.3.900.900 10.1016/j.biologicals.2017.12.003 10.1097/MBC.0b013e328343312f 10.1007/s12288-015-0604-4 10.1111/j.1423-0410.2010.01374.x 10.1097/EJA.0000000000000780 10.1093/bja/aeu086 10.1111/anae.14842 10.1111/jth.12372 10.1111/ijlh.13098 10.1111/trf.15749 |
| ContentType | Journal Article |
| Copyright | Copyright © 2021 Huisman and Crighton. Copyright © 2021 Huisman and Crighton. 2021 Huisman and Crighton |
| Copyright_xml | – notice: Copyright © 2021 Huisman and Crighton. – notice: Copyright © 2021 Huisman and Crighton. 2021 Huisman and Crighton |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fped.2021.617500 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2296-2360 |
| ExternalDocumentID | oai_doaj_org_article_466976731fe142c1a9e8eaaeff1c9328 PMC8097151 33968842 10_3389_fped_2021_617500 |
| Genre | Journal Article Review |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM EMOBN IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c462t-508a8e53110dbe0ae2011e3b307183fbb270636801334cbe5dfb7d3f80bd3f973 |
| IEDL.DBID | DOA |
| ISSN | 2296-2360 |
| IngestDate | Wed Aug 27 01:20:14 EDT 2025 Thu Aug 21 13:32:24 EDT 2025 Fri Jul 11 04:03:11 EDT 2025 Thu Apr 03 06:55:19 EDT 2025 Thu Apr 24 22:51:20 EDT 2025 Tue Jul 01 01:33:46 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | hypofibrinogenemia fibrinogen intensive care children viscoelastic testing Clauss cryoprecipitate fibrinogen concentrate |
| Language | English |
| License | Copyright © 2021 Huisman and Crighton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c462t-508a8e53110dbe0ae2011e3b307183fbb270636801334cbe5dfb7d3f80bd3f973 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: E. Vincent S. Faustino, School of Medicine Yale University, United States; Joyce Ching Mei Lam, Paediatric Haematology/Oncology Service, KK Women's and Children's Hospital, Singapore This article was submitted to Pediatric Critical Care, a section of the journal Frontiers in Pediatrics Edited by: Jan Hau Lee, KK Women's and Children's Hospital, Singapore |
| OpenAccessLink | https://doaj.org/article/466976731fe142c1a9e8eaaeff1c9328 |
| PMID | 33968842 |
| PQID | 2524872515 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_466976731fe142c1a9e8eaaeff1c9328 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8097151 proquest_miscellaneous_2524872515 pubmed_primary_33968842 crossref_primary_10_3389_fped_2021_617500 crossref_citationtrail_10_3389_fped_2021_617500 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-04-21 |
| PublicationDateYYYYMMDD | 2021-04-21 |
| PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-21 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in pediatrics |
| PublicationTitleAlternate | Front Pediatr |
| PublicationYear | 2021 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Whiting (B16) 2014; 89 Velik-Salchner (B1) 2007; 5 Sokou (B32) 2017; 55 Cushing (B55) 2017; 57 (B91) 2015 Liu (B28) 2019; 41 van Veen (B22) 2008; 142 Lowe (B23) 2004; 41 Oakley (B70) 2015; 55 Gerlach (B53) 2002; 33 Rock (B62) 2011; 100 Solomon (B85) 2015; 113 Faraoni (B6) 2014; 31 Girelli (B90) 2015; 13 (B61) 2019 Harvey (B65) 2015; 55 Hunt (B86) 2015; 170 (B95) 2014 Mackie (B11) 2003; 121 Haas (B82) 2018; 78 Levy (B43) 2014; 54 Kasper (B50) 2012; 18 (B78) 2017 Sampson (B71) 2011; 21 Goobie (B87) 2019; 29 Appel (B29) 2012; 10 Mosesson (B2) 2001; 936 Erdoes (B79) 2019; 74 B74 Theusinger (B48) 2011; 106 B75 (B89) 2016 B77 Stang (B12) 2013 Listyo (B54) 2020; 9 Di Minno (B59) 2017; 96 Ignjatovic (B35) 2011; 22 New (B88) 2016; 175 Mirabella (B34) 2017; 83 Hiippala (B3) 1995; 81 Bolton-Maggs (B68) 2017; 27 Tang (B9) 2020; 2020 (B46) 2013 Brown (B36) 2016; 124 Reverdiau-Moalic (B27) 1996; 88 Elliot (B69) 2020 Monagle (B38) 2006; 95 (B45) 2020 Thy (B13) 2018; 35 B80 Solomon (B41) 2010; 104 B84 Sante (B76) 2009 Kozek-Langenecker (B14) 2005; 103 Liu (B30) 2019; 41 Ogawa (B21) 2015; 120 Buckley (B47) 2019; 59 (B60) 2019 Galas (B39) 2014; 148 (B72) 2001 Ryan (B18) 2014; 49 Nascimento (B51) 2014; 113 Wong (B57) 2018; 13 Rizoli (B20) 2016; 181 Luyendyk (B7) 2019; 133 Hochart (B26) 2019; 45 Green (B96) 2018; 181 Haas (B17) 2020; 60 Kumar (B67) 2016; 32 Raes (B94) 2006; 6 Niederwanger (B8) 2018; 8 Chan (B19) 2007; 105 Attard (B24) 2013; 11 Lee (B42) 2014; 54 Yan (B52) 2018; 57 (B44) 2014 (B92) 2014 B56 Schulz (B81) 2018; 52 Downey (B40) 2020; 130 Grottke (B83) 2020; 60 Ranucci (B5) 2019; 34 Christensen (B25) 2014; 54 Bucak (B10) 2019; 13 Cushing (B63) 2019; 59 Oswald (B31) 2010; 105 Vossoughi (B66) 2018; 58 Franchini (B73) 2012; 10 Barcelona (B93) 2005; 15 Fries (B4) 2010; 105 Theodoraki (B33) 2020; 7 Molinaro (B15) 2008; 109 Parmar (B37) 2006; 52 Collins (B49) 2014; 113 Okerberg (B58) 2016; 111 Mumford (B64) 2014; 167 |
| References_xml | – volume: 10 start-page: 2254 year: 2012 ident: B29 article-title: Age dependency of coagulation parameters during childhood and puberty publication-title: J Thromb Haemost. doi: 10.1111/j.1538-7836.2012.04905.x – volume-title: Blood Transfusion year: 2015 ident: B91 – volume: 105 start-page: 116 year: 2010 ident: B4 article-title: Role of fibrinogen in trauma-induced coagulopathy publication-title: Br J Anaesth. doi: 10.1093/bja/aeq161 – volume: 109 start-page: 160 year: 2008 ident: B15 article-title: Low plasma fibrinogen levels with the Clauss method during anticoagulation with bivalirudin publication-title: Anesthesiology. doi: 10.1097/ALN.0b013e31817885b7 – volume: 21 start-page: 73 year: 2011 ident: B71 article-title: DEHP-plasticised PVC: relevance to blood services publication-title: Transfus Med. doi: 10.1111/j.1365-3148.2010.01056.x – start-page: 578 volume-title: Technical Manual. year: 2014 ident: B95 article-title: Chapter 23: Neonatal and pediatric transfusion practice – volume: 41 start-page: 430 year: 2004 ident: B23 article-title: Plasma fibrinogen publication-title: Ann Clin Biochem. doi: 10.1258/0004563042466884 – volume: 113 start-page: 759 year: 2015 ident: B85 article-title: Safety of fibrinogen concentrate: analysis of more than 27 years of pharmacovigilance data publication-title: Thromb Haemost. doi: 10.1160/TH14-06-0514 – volume: 60 start-page: S75 year: 2020 ident: B17 article-title: Viscoelastic testing in pediatric patients publication-title: Transfusion. doi: 10.1111/trf.16076 – volume: 59 start-page: 837 year: 2019 ident: B47 article-title: Challenges to producing novel therapies - dried plasma for use in trauma and critical care publication-title: Transfusion. doi: 10.1111/trf.14985 – volume: 9 start-page: 2456 year: 2020 ident: B54 article-title: The need for red cell support during non-cardiac surgery is associated to pre-transfusion levels of FXIII and the platelet count publication-title: J Clin Med. doi: 10.3390/jcm9082456 – volume: 181 start-page: 117 year: 2016 ident: B20 article-title: In trauma, conventional ROTEM and TEG results are not interchangeable but are similar in clinical applicability publication-title: Mil Med. doi: 10.7205/MILMED-D-15-00166 – volume: 111 start-page: 292 year: 2016 ident: B58 article-title: Cryoprecipitate AHF vs. fibrinogen concentrates for fibrinogen replacement in acquired bleeding patients - an economic evaluation publication-title: Vox Sang. doi: 10.1111/vox.12417 – volume: 41 start-page: 530 year: 2019 ident: B30 article-title: Establishing a reference range for thromboelastograph parameters in the neonatal period publication-title: Int J Lab Hematol. doi: 10.1111/ijlh.13043 – volume: 58 start-page: 60 year: 2018 ident: B66 article-title: Analysis of pediatric adverse reactions to transfusions publication-title: Transfusion. doi: 10.1111/trf.14359 – volume: 13 start-page: 23 year: 2018 ident: B57 article-title: Do we need cryoprecipitate in the era of fibrinogen concentrate and other specific factor replacement options? publication-title: ISBT Sci Ser. doi: 10.1111/voxs.12376 – ident: B77 – volume: 121 start-page: 396 year: 2003 ident: B11 article-title: Guidelines on fibrinogen assays publication-title: Br J Haematol. doi: 10.1046/j.1365-2141.2003.04256.x – volume: 55 start-page: 563 year: 2015 ident: B70 article-title: Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products publication-title: Transfusion. doi: 10.1111/trf.12827 – volume: 54 start-page: 1379 year: 2014 ident: B42 article-title: Fibrinogen recovery and changes in fibrin-based clot firmness after cryoprecipitate administration in patients undergoing aortic surgery involving deep hypothermic circulatory arrest publication-title: Transfusion. doi: 10.1111/trf.12479 – volume: 106 start-page: 505 year: 2011 ident: B48 article-title: Relative concentrations of haemostatic factors and cytokines in solvent/detergent-treated and fresh-frozen plasma publication-title: Br J Anaesth. doi: 10.1093/bja/aer003 – volume-title: National Blood Authority, Annual Report. ident: B56 – volume: 6 start-page: 3 year: 2006 ident: B94 article-title: A reference frame for blood volume in children and adolescents publication-title: BMC Pediatr. doi: 10.1186/1471-2431-6-3 – volume: 105 start-page: 1610 year: 2007 ident: B19 article-title: Reference values for kaolin-activated thromboelastography in healthy children publication-title: Anesth Analg. doi: 10.1213/01.ane.0000287645.26763.be – volume-title: Safety Assessment of Di(2-ethylhexyl)phthalate (DEHP) Released from PVC Medical Devices year: 2001 ident: B72 – volume: 59 start-page: 1818 year: 2019 ident: B63 article-title: Efficacy of a new pathogen-reduced cryoprecipitate stored 5 days after thawing to correct dilutional coagulopathy in vitro publication-title: Transfusion. doi: 10.1111/trf.15157 – volume: 89 start-page: 228 year: 2014 ident: B16 article-title: TEG and ROTEM: technology and clinical applications publication-title: Am J Hematol. doi: 10.1002/ajh.23599 – volume: 49 start-page: 1295 year: 2014 ident: B18 article-title: Trauma induced hypercoagulablity in pediatric patients publication-title: J Pediatr Surg. doi: 10.1016/j.jpedsurg.2013.11.050 – volume: 31 start-page: 317 year: 2014 ident: B6 article-title: Plasma fibrinogen concentration is correlated with postoperative blood loss in children undergoing cardiac surgery. A retrospective review publication-title: Eur J Anaesthesiol. doi: 10.1097/EJA.0000000000000043 – volume: 7 start-page: 259 year: 2020 ident: B33 article-title: Reference values of thrombolastometry parameters in healthy term neonates publication-title: Children. doi: 10.3390/children7120259 – volume: 78 start-page: 230 year: 2018 ident: B82 article-title: Comparison of the efficacy of two human fibrinogen concentrates to treat dilutional coagulopathy in vitro publication-title: Scand J Clin Lab Invest. doi: 10.1080/00365513.2018.1437645 – volume: 29 start-page: 231 year: 2019 ident: B87 article-title: Society for the advancement of blood management administrative and clinical standards for patient blood management programs publication-title: Paediatr Anaesth doi: 10.1111/pan.13574 – volume-title: On behalf of the Serious Hazards of Transfusion (SHOT) Steering Group year: 2020 ident: B69 – year: 2019 ident: B61 publication-title: World Federation of Hemophilia Statement on Cryoprecipitate for Treatment of Congenital Bleeding Disorders – volume: 8 start-page: 111 year: 2018 ident: B8 article-title: Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis publication-title: Ann Intensive Care. doi: 10.1186/s13613-018-0457-8 – volume: 103 start-page: 654 year: 2005 ident: B14 article-title: Effects of hydroxyethyl starch solutions on hemostasis publication-title: Anesthesiology. doi: 10.1097/00000542-200509000-00031 – start-page: 151 year: 2014 ident: B44 article-title: Chapter 6: Whole blood collection and component processing – volume: 81 start-page: 360 year: 1995 ident: B3 article-title: Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates publication-title: Anesth Analg. doi: 10.1213/00000539-199508000-00026 – volume: 83 start-page: 369 year: 2017 ident: B34 article-title: Reference values for coagulation assessment in full-term newborns publication-title: Minerva Anestesiol. doi: 10.23736/S0375-9393.16.11375-6 – year: 2013 ident: B46 publication-title: Guidelines for the Blood Transfusion Services in the UK – volume: 2020 start-page: 9153620 year: 2020 ident: B9 article-title: Fibrinogen as a prognostic predictor in pediatric patients with sepsis: a database study publication-title: Mediators Inflamm. doi: 10.1155/2020/9153620 – volume: 142 start-page: 889 year: 2008 ident: B22 article-title: Thrombin generation testing in routine clinical practice: are we there yet? publication-title: Br J Haematol. doi: 10.1111/j.1365-2141.2008.07267.x – volume: 936 start-page: 11 year: 2001 ident: B2 article-title: The structure and biological features of fibrinogen and fibrin publication-title: Ann N Y Acad Sci. doi: 10.1111/j.1749-6632.2001.tb03491.x – volume: 54 start-page: 1389 year: 2014 ident: B43 article-title: Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy publication-title: Transfusion. doi: 10.1111/trf.12431 – volume: 148 start-page: 1647 year: 2014 ident: B39 article-title: Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate in children after cardiac surgery: a randomized pilot trial publication-title: J Thorac Cardiovasc Surg. doi: 10.1016/j.jtcvs.2014.04.029 – start-page: 181 volume-title: Haemostasis: Methods and Protocols. year: 2013 ident: B12 article-title: Chapter 14: Fibrinogen doi: 10.1007/978-1-62703-339-8_14 – volume: 55 start-page: 1592 year: 2017 ident: B32 article-title: Reference ranges of thromboelastometry in healthy full-term and pre-term neonates publication-title: Clin Chem Lab Med. doi: 10.1515/cclm-2016-0931 – volume: 13 start-page: e103 year: 2019 ident: B10 article-title: Evaluation of platelet parameters and acute phase reactants in pediatric patients presenting with fever publication-title: J Pediatr Inf. doi: 10.5578/ced.68125 – volume: 54 start-page: 627 year: 2014 ident: B25 article-title: Reference intervals for common coagulation tests of preterm infants (CME) publication-title: Transfusion. doi: 10.1111/trf.12322 – volume: 52 start-page: 115 year: 2006 ident: B37 article-title: The fibrinolytic system in newborns and children publication-title: Clin Lab. – volume: 34 start-page: 629 year: 2019 ident: B5 article-title: Fibrinogen levels and postoperative chest drain blood loss in low-weight (<10 kg) children undergoing cardiac surgery publication-title: Perfusion. doi: 10.1177/0267659119854246 – volume: 13 start-page: 484 year: 2015 ident: B90 article-title: Recommendations for transfusion therapy in neonatology publication-title: Blood Transfus. doi: 10.2450/2015.0113-15 – volume: 120 start-page: 18 year: 2015 ident: B21 article-title: Fibrinogen measurements in plasma and whole blood: a performance evaluation study of the dry-hematology system publication-title: Anesth Analg. doi: 10.1213/ANE.0000000000000448 – volume: 104 start-page: 555 year: 2010 ident: B41 article-title: Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery publication-title: Br J Anaesth. doi: 10.1093/bja/aeq058 – volume: 33 start-page: 1618 year: 2002 ident: B53 article-title: Increased risk for postoperative hemorrhage after intracranial surgery in patients with decreased factor XIII activity: implications of a prospective study publication-title: Stroke. doi: 10.1161/01.STR.0000017219.83330.FF – start-page: 39 volume-title: Technical Manual. year: 2014 ident: B92 article-title: Chapter 2: Facilities, work environment, and safety – volume: 124 start-page: 1021 year: 2016 ident: B36 article-title: Fibrin network changes in neonates after cardiopulmonary bypass publication-title: Anesthesiology. doi: 10.1097/ALN.0000000000001058 – volume: 55 start-page: 709 year: 2015 ident: B65 article-title: Transfusion-related adverse reactions reported to the national healthcare safety network hemovigilance module, United States, 2010 to 2012 publication-title: Transfusion. doi: 10.1111/trf.12918 – volume: 96 start-page: 1253 year: 2017 ident: B59 article-title: Pathogen reduction/inactivation of products for the treatment of bleeding disorders: what are the processes and what should we say to patients? publication-title: Ann Hematol. doi: 10.1007/s00277-017-3028-4 – volume: 170 start-page: 788 year: 2015 ident: B86 article-title: A practical guideline for the haematological management of major haemorrhage publication-title: Br J Haematol. doi: 10.1111/bjh.13580 – volume: 45 start-page: 113 year: 2019 ident: B26 article-title: Hemostatic profile of infants with spontaneous prematurity: can we predict intraventricular hemorrhage development? publication-title: Ital J Pediatr. doi: 10.1186/s13052-019-0709-8 – volume: 57 start-page: 724 year: 2018 ident: B52 article-title: Acquired factor XIII deficiency: a review publication-title: Transfus Apher Sci. doi: 10.1016/j.transci.2018.10.013 – volume: 15 start-page: 814 year: 2005 ident: B93 article-title: Intraoperative pediatric blood transfusion therapy: a review of common issues. Part II: transfusion therapy, special considerations, and reduction of allogenic blood transfusions publication-title: Paediatr Anaesth. doi: 10.1111/j.1460-9592.2004.01549.x – volume-title: Patient Blood Management Guidelines: Module 6 - Neonates and Paediatrics year: 2016 ident: B89 – volume: 105 start-page: 827 year: 2010 ident: B31 article-title: Thromboelastometry (ROTEM) in children: age-related reference ranges and correlations with standard coagulation tests publication-title: Br J Anaesth. doi: 10.1093/bja/aeq258 – volume: 5 start-page: 1019 year: 2007 ident: B1 article-title: The effect of fibrinogen concentrate on thrombocytopenia publication-title: J Thromb Haemost. doi: 10.1111/j.1538-7836.2007.02481.x – volume-title: Guide to the Preparation, Use and Quality Assurance of Blood Components year: 2020 ident: B45 – volume: 18 start-page: 883 year: 2012 ident: B50 article-title: Judith Graham Pool and the discovery of cryoprecipitate publication-title: Haemophilia. doi: 10.1111/hae.12042 – volume: 113 start-page: 922 year: 2014 ident: B51 article-title: Cryoprecipitate therapy publication-title: Br J Anaesth. doi: 10.1093/bja/aeu158 – volume: 181 start-page: 54 year: 2018 ident: B96 article-title: British Society of Haematology Guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: their handling and use in various patient groups in the absence of major bleeding publication-title: Br J Haematol. doi: 10.1111/bjh.15167 – volume-title: Product Monograph including Patient Medication Information year: 2017 ident: B78 – ident: B75 – volume: 175 start-page: 784 year: 2016 ident: B88 article-title: Guidelines on transfusion for fetuses, neonates and older children publication-title: Br J Haematol. doi: 10.1111/bjh.14233 – volume: 10 start-page: 23 year: 2012 ident: B73 article-title: Fibrinogen replacement therapy: a critical review of the literature publication-title: Blood Transfus. doi: 10.2450/2011.0015-11 – year: 2009 ident: B76 article-title: CLOTTAFACT 1.5 g/100 ml, powder and solvent for solution for injection publication-title: LFB-Biomedicaments – volume: 95 start-page: 362 year: 2006 ident: B38 article-title: Developmental haemostasis. Impact for clinical haemostasis laboratories publication-title: Thromb Haemost. doi: 10.1160/TH05-01-0047 – ident: B84 – volume: 27 start-page: 393 year: 2017 ident: B68 article-title: Serious hazards of transfusion - conference report: celebration of 20 years of UK haemovigilance publication-title: Transfus Med. doi: 10.1111/tme.12502 – volume: 133 start-page: 511 year: 2019 ident: B7 article-title: The multifaceted role of fibrinogen in tissue injury and inflammation publication-title: Blood. doi: 10.1182/blood-2018-07-818211 – volume: 167 start-page: 304 year: 2014 ident: B64 article-title: Guideline for the diagnosis and management of the rare coagulation disorders: a United Kingdom Haemophilia Centre Doctors' Organization guideline on behalf of the British Committee for Standards in Haematology publication-title: Br J Haematol. doi: 10.1111/bjh.13058 – volume: 130 start-page: 740 year: 2020 ident: B40 article-title: Fibrinogen concentrate as an alternative to cryoprecipitate in a postcardiopulmonary transfusion algorithm in infants undergoing cardiac surgery: a prospective randomized controlled trial publication-title: Anesth Analg. doi: 10.1213/ANE.0000000000004384 – volume-title: WHO Blood Regulators Network (BRN) Position Statement on Use of Pathogenof bleeding disorders: what are the processes and what should weactor Concentrates are Unavailable or Unaffordable year: 2019 ident: B60 – volume: 57 start-page: 2502 year: 2017 ident: B55 article-title: Influence of cryoprecipitate, Factor XIII, and fibrinogen concentrate on hyperfibrinolysis publication-title: Transfusion. doi: 10.1111/trf.14259 – volume: 88 start-page: 900 year: 1996 ident: B27 article-title: Evolution of blood coagulation activators and inhibitors in the healthy human fetus publication-title: Blood. doi: 10.1182/blood.V88.3.900.900 – ident: B80 – volume: 52 start-page: 72 year: 2018 ident: B81 article-title: Biochemical characterization, stability, and pathogen safety of a new fibrinogen concentrate (fibryga((R))) publication-title: Biologicals. doi: 10.1016/j.biologicals.2017.12.003 – volume: 22 start-page: 110 year: 2011 ident: B35 article-title: Evidence for age-related differences in human fibrinogen publication-title: Blood Coagul Fibrinolysis. doi: 10.1097/MBC.0b013e328343312f – volume: 32 start-page: 320 year: 2016 ident: B67 article-title: Transfusion related acute lung injury (TRALI): a single institution experience of 15 years publication-title: Indian J Hematol Blood Transfus. doi: 10.1007/s12288-015-0604-4 – volume: 100 start-page: 169 year: 2011 ident: B62 article-title: A comparison of methods of pathogen inactivation of FFP publication-title: Vox Sang. doi: 10.1111/j.1423-0410.2010.01374.x – volume: 35 start-page: 484 year: 2018 ident: B13 article-title: Safety and efficacy of peri-operative administration of hydroxyethyl starch in children undergoing surgery: A systematic review and meta-analysis publication-title: Eur J Anaesthesiol. doi: 10.1097/EJA.0000000000000780 – volume: 113 start-page: 585 year: 2014 ident: B49 article-title: Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate publication-title: Br J Anaesth. doi: 10.1093/bja/aeu086 – ident: B74 – volume: 74 start-page: 1589 year: 2019 ident: B79 article-title: The role of fibrinogen and fibrinogen concentrate in cardiac surgery: an international consensus statement from the haemostasis and transfusion scientific subcommittee of the european association of cardiothoracic anaesthesiology publication-title: Anaesthesia. doi: 10.1111/anae.14842 – volume: 11 start-page: 1850 year: 2013 ident: B24 article-title: Developmental hemostasis: age-specific differences in the levels of hemostatic proteins publication-title: J Thromb Haemost. doi: 10.1111/jth.12372 – volume: 41 start-page: 697 year: 2019 ident: B28 article-title: Paediatric reference intervals for common coagulation assays in Chinese children as performed on the STA-R coagulation analyzer publication-title: Int J Lab Hematol. doi: 10.1111/ijlh.13098 – volume: 60 start-page: 663 year: 2020 ident: B83 article-title: The use of coagulation factor concentrates for perioperative bleeding management - a global perspective publication-title: Transfusion. doi: 10.1111/trf.15749 |
| SSID | ssj0000970515 |
| Score | 2.1920338 |
| SecondaryResourceType | review_article |
| Snippet | Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding.... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 617500 |
| SubjectTerms | children Clauss fibrinogen hypofibrinogenemia intensive care Pediatrics viscoelastic testing |
| SummonAdditionalLinks | – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQkRAXxJvlJSNx4ZA2fsXJoUJQdVWQFu2BlXqz7GQMK62SdneL4NYf0V_YX8JMkoZdtOLEJYfYThx_nsw3cfwNY2-DECGNXiVW05acaHUSdFElQnpjQENlPW1wnnzJTmb686k5_bM9uh_A1c7QjvJJzZaL_Z_nv96jwR9SxIn-9iCeAWl-SrGP7tikGMDfRr9kKZHDpCf77Xu5sJTQpFur3Nlwyze1Ev67eOffv09u-KPxfXavJ5L8Q4f8A3YL6ofszqRfKn_EfgxJOPiYfuuvG5wqfIr8lX-6vryaztfRLxYrPq83y48H8W_u64rPVsCbuFkBCTt9eKdvinzaqcW21zjqN4U_ZrPx8dejk6RPspCUiM46QYLmc0BLFGkVIPVAjABUQNtHa48hSIssJkNHppQuA5gqBlupmKcBj4VVT9he3dTwjHEffFoW0Qivcw0y8wanaeoNSXoJH82IHdwMryt7BXJKhLFwGIkQII4AcQSI6wAZsXdDi7NOfeMfdT8SYkM90s1uTzTLb643Q6ezDPmXVSKC0LIUvoAcvIcYRYlMNh-xNzd4O7QzWjzxNTQXKyeNxNgO2SA-xtMO_-FWShVZnms5YnZrZmz1Zbuknn9vtbxz0vAy4vn_6PwLdpfGg9a6pHjJ9tbLC3iFlGkdXreW8Bs6QxeJ priority: 102 providerName: Scholars Portal |
| Title | Pediatric Fibrinogen PART I—Pitfalls in Fibrinogen Evaluation and Use of Fibrinogen Replacement Products in Children |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33968842 https://www.proquest.com/docview/2524872515 https://pubmed.ncbi.nlm.nih.gov/PMC8097151 https://doaj.org/article/466976731fe142c1a9e8eaaeff1c9328 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELbQHhAXxJvykpG4cAiNX3FyhNVWC1JRD1TamzVOxqJSla62Xc78CH4hv4SZJBulCMGFiw-xkziemcznx3wjxJuoVMwTmMxbDslJ3mbRVk2mNDiHFhsPHOC8_Fycr-2nC3cxSfXFZ8J6euB-4Oa2KMhjeqMSKqtrBRWWCIApqZqwRxfmSz5vMpnq_sGV5-Ql_b4kzcKqebpEJgbV6h35bMcBbRM_1NH1_wlj_n5UcuJ7FvfE3QE0yvd9Z--LW9g-ELeXw7b4Q_FtTLghF3yEv92RWsgVYVX58ef3H6vNIcF2u5ebdlp_NhJ9S2gbud6j3KVpAwLnvMjO64dy1TPDds84HQLAH4n14uzL6Xk2JFTIapLEISMwBiWS1am8iZgDsvdHE8nOybJTjNoTYinIaRlj64iuSdE3JpV5pLLy5rE4aXctPhUSIuR1lZwCW1rUBThSyRwc03cpSG4m5jfDG-qBbZyTXmwDzTpYIIEFElggoRfITLwd77jsmTb-0vYDS2xsxxzZ3QXSnDBoTviX5szE6xt5B7Ip3iiBFnfX-6CdpnkcIT_6jCe9_MdXGVMVZWn1TPgjzTjqy3FNu_na8XaXzNfl1LP_0fnn4g6PB-9rafVCnByurvElwaNDfNVZApVLW_4CEpgQoQ |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pediatric+Fibrinogen+PART+I%E2%80%94Pitfalls+in+Fibrinogen+Evaluation+and+Use+of+Fibrinogen+Replacement+Products+in+Children&rft.jtitle=Frontiers+in+pediatrics&rft.au=Elise+J.+Huisman&rft.au=Elise+J.+Huisman&rft.au=Elise+J.+Huisman&rft.au=Gemma+Louise+Crighton&rft.date=2021-04-21&rft.pub=Frontiers+Media+S.A&rft.eissn=2296-2360&rft.volume=9&rft_id=info:doi/10.3389%2Ffped.2021.617500&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_466976731fe142c1a9e8eaaeff1c9328 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2296-2360&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2296-2360&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2296-2360&client=summon |