The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors

• Published in: Therapeutic advances in neurological disorders Vol. 14; p. 1756286421997381
• Main Authors: Dalakas, Marinos C., Spaeth, Peter J.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 2021; SAGE PUBLICATIONS, INC
• Subjects: Blood-brain barrier; Cell surface; Clinical trials; Endothelium; Fc receptors; Gene polymorphism; Immunoglobulin G; Immunotherapy; Intravenous administration; Lysosomes; Monoclonal antibodies; Myasthenia gravis; Neonates; Neurological diseases; Neuromuscular junctions; Patients; Pharmacokinetics; Progressive motor neuropathy; Review; FcRn; autoantibodies; FCGRT gene polymorphisms; IgG catabolism IVIg; Neuro-mmunotherapies; Autoimmune neurology

The neonatal Fc receptor (FcRn) binds endogenous IgG and protects it from lysosomal degradation by transporting it back to the cell surface to re-enter the circulation, extending the serum IgG life span. FcRn plays a role in the function of IVIg because the supraphysiological IgG levels derived from...