Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release - Dai, Xiao-Yan; Zhao, Ming-Ming; Cai, Yan; Guan, Qing-Cong; Zhao, Ying; Guan, Youfei; Kong, Wei; Zhu, Wei-Guo; Xu, Ming-Jiang; Wang, Xian (Kidney international, 2013)
Keywords: Adenine - analogs & derivatives; Adenine - pharmacology; Alkaline Phosphatase - metabolism; Amino Acid Chloromethyl Ketones - pharmacology; Animals; Antioxidants - pharmacology; apoptosis; autophagy; Autophagy - drug effects; Autophagy-Related Protein 5; Caspase Inhibitors - pharmacology; Cattle; Cells, Cultured; chronic renal failure; Disease Models, Animal; hyperphosphatemia; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - pathology; Metalloporphyrins - pharmacology; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; oxidative stress; Phosphates - metabolism; Proteins - genetics; Proteins - metabolism; Rats; RNA Interference; Secretory Vesicles - drug effects; Secretory Vesicles - metabolism; Secretory Vesicles - pathology; Sodium-Phosphate Cotransporter Proteins, Type III - genetics; Sodium-Phosphate Cotransporter Proteins, Type III - metabolism; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Time Factors; Transfection; Valproic Acid - pharmacology; Vascular Calcification - etiology; Vascular Calcification - metabolism; Vascular Calcification - pathology; Vascular Calcification - prevention & control; apoptosis; autophagy; chronic renal failure; hyperphosphatemia; oxidative stress